Application of phosphatidylethanol (PEth) in whole blood in comparison to ethyl glucuronide in hair (hEtG) in driving aptitude assessment (DAA)

For driving aptitude assessment (DAA), the analysis of several alcohol biomarkers is essential for the detection of alcohol intake besides psycho-medical exploration. In Switzerland, EtG in hair (hEtG) is often the only direct marker for abstinence monitoring in DAA. Therefore, the suitability of phosphatidylethanol (PEth) was investigated as additional biomarker. PEth 16:0/18:1 and 16:0/18:2 were determined by online-SPE-LC-MS/MS in 136 blood samples of persons undergoing DAA and compared to hEtG, determined in hair segments taken at the same time. With a PEth 16:0/18:1 threshold of 210 ng/mL for excessive alcohol consumption, all (n = 30) but one tested person also had hEtG values ≥30 pg/mg. In 54 cases, results are not in contradiction to an abstinence as neither PEth (<20 ng/mL) nor hEtG (<7 pg/mg) was detected. In eight cases, both markers showed moderate consumption. Altogether, PEth and hEtG were in accordance in 68 % of the samples, although covering different time periods of alcohol consumption. With receiver operating characteristic analysis, PEth was evaluated to differentiate abstinence, moderate, and excessive alcohol consumption in accordance with hEtG limits. A PEth 16:0/18:1 threshold of 150 ng/mL resulted in the best sensitivity (70.6 %) and specificity (98.8 %) for excessive consumption. Values between 20 and 150 ng/mL passed for moderate consumption, values <20 ng/mL passed for abstinence. As PEth mostly has a shorter detection window (2-4 weeks) than hEtG (up to 6 months depending on hair length), changes in drinking behavior can be detected earlier by PEth than by hEtG analysis alone. Therefore, PEth helps to improve the diagnostic information and is a valuable additional alcohol marker for DAA.

Application of numerical classification in ecological investigations of water pollution /

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Aftereffects of brain injuries in war, their evaluation and treatment; the application of psychologic methods in the clinic,

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Guidelines for the application of arrow boards in work zones. Final report.

Federal Highway Administration, Office of Research, Washington, D.C.

Human engineering; a study of the management of human forces in industry,

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Application of measurement criteria in the selection of interactive computer services /

"Issued April 1980."

Guidelines for the application of arrow boards in work zones /

Mode of access: Internet.

A possible application of organic fibers in high temperature environment /

This report was prepared by Fabric Research Laboratories, Inc. under USAF Contract No. AF33 (616)--6234 under Project No. 7320, Task No. 73201.

Application of atomic engines in aviation

"Introductory pages 1-5 have been omitted."

Domestic portraiture; or, The successful application of religious principle in the education of a family, exemplified in the memoirs of three of the deceased children of the Rev. Legh Richmond.

"New York: Printed by R. & G. S. Wood."