Studies on the synthesis and cns activity of strychnine derivatives

Strychnine, the major alkaloid present in Strychnos nuxvomica seeds has been reported to stimulate the entire central nervous system with preference for the spinal cord. It is a powerful convulsant and because of this property, it is an important pharmacological tool as it plays a unique role as an inhibitor of post synaptic inhibitory impulses. It is useful to study inhibitory transmitter and receptor types. However, because of its extreme toxicity, strychnine does not have any therapeutic application in the Western system of medicine. The present work was undertaken with a view to obtaining strychnine derivatives having CNS stimulating properties but with sufficiently low toxicity so that they may eventually find some application in medicine. As strychnine is isolated from the locally available strychnos Nugvomica seeds, it’s possible utilization in therapeutics will have considerable commercial significance. This work tries to provide several new compounds which are significantly less toxic than strychnine and its N—oxide as shown from the pharmacological Studio As they also possessed CNS stimulating properties, they are well suited for further screening to assess their potential as valuable therapeutic agents.

Report [A].

Text in French.

Méthode de langage français et annamite destinée aux écoles de l'Indochine. Suivie d'un abrégé géographique (Cours élémentaire)

Name of distributor, Librairie Orientale H. Samuelian, Paris, stamped on t.p.

F. Sylvii ... Commentarii in totam primam secundae S. Thomae Aquinatis ... : tomus secundus.

Mode of access: Internet.

Le Copépodes pélagiques de la Baie de Cauda (Viet-Nam)

The author presents his study on marine pelagic fishes collected on the coast of Annam, in the Bay of Cauda, where the Indochina government built the Institute of Oceanography. These samples allowed the systematic identification of pelagic Copepods.

Siphonophores calycophorides de la Baie de Nhatrang-Cauda

In 1953, the author received a collection of clans Siphonophores collected in Nha Trang Bay by the Director of the Maritime Station of Cauda, Nha Trang (Annam), Vietnam. This paper gives the results of his studies.