Comparative genomics of the neglected human malaria parasite Plasmodium vivax

The human malaria parasite Plasmodium vivax is responsible for 25 - 40% of the similar to 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non- human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Justicia política y educación ciudadana

Tabla de contenidos: La concepción política de la justicia. La educación ciudadana y su justificación política. La virtud ciudadadna : Sus componentes básicos y su justificación. La identidad ciudadana y las bases de la unidad social. El cosmopolitismo y la educación ciudadana. La educación ciudadana en Argentina.

Justicia política y educación ciudadana

Tabla de contenidos: La concepción política de la justicia. La educación ciudadana y su justificación política. La virtud ciudadadna : Sus componentes básicos y su justificación. La identidad ciudadana y las bases de la unidad social. El cosmopolitismo y la educación ciudadana. La educación ciudadana en Argentina.

España: evolutionism & religion, Century XIX

From the Englightenment to the middle of the 19th century, geological time and the antiquity of human beings received ever growing attention. This was caused by a series of events, such as: *the beginnings of experimentation in Geology (Buffon, 1778) *the development of the transformism (Lamarck, 1809) *the recognition and description of extinct animals (Cuvier, 1812) *as well as the studies made in alluvial deposits, caves and gravel beds, with brought to light artefacts, human rest and bone of extinguished animals (from John Frere, 1797, to Albert Gaudry, 1859). The development towards evolutionism (Darwin, 1859) came gradually. In Spain, all these currents found their echo: Spain, e.g. was the third country where the Palaeolithic remains were discovered (Verneuil and Lartet, 1863). Also the Darwin ideas were introduced forcefully, right from the beginning. But the change in worldview, which was prerequisite to these ideas, lead to polemic controversies in the political and religious realm. The most significant evidence was the official prohibition of the teaching Darwinism in public educational centres (1875). At theological level, thanks to the advance of the geologic knowledge, went leaving the literal interpretations of Biblical texts was eventually discontinued and replaced by more liberal interpretation. In some case, the process was difficult because some political, religious and scientific authors and researchers didn’t understand the new scientific ideas.

Commonplace book of Hector Orr, 1789-1804

Hector Orr began recording entries in this commonplace book during his first year as a student at Harvard and continued writing in the volume sporadically until 1804. The entries written while he was a student, from 1789 to 1792, include themes written on the following topics: Time, Discontent, Patriotism, Virtue, Conscience, Patience, Avarice, Compassion, Mortality, Self-knowledge, Benevolence, Morning, Anger, Profanity, Bribery, Autumn and Winter, Hermitage, Conscience and Anticipation. He also wrote detailed entries about the forensic disputations in which he and his classmates participated, explaining both the affirmative and negative positions. One of these disputations involved discussion of the Stamp Act, which was then quite recent history. Orr's entries about the disputations list the names of students involved and specify their position in the argument.

Collection of Harvard College admission form letter and bills sent to Charles Walker and his son Charles Walker, Jr., 1785-1816

This collection consists primarily of quarter bills and butler's bills from Charles Walker and Charles Walker, Jr.'s years as students at Harvard College, from 1785 to 1789 and from 1815-1816. It includes the following materials from Charles Walker: a form of admission (a printed form letter with manuscript annotations and signatures) from August 1785, quarter bills and butler's bills from 1785 to 1789, and occasional receipts of payment. The documents from Charles Walker, Jr. are less numerous, consisting solely of quarter bills from 1815 and 1816. The bills for father and son include annotations explaining the basis of additional or unusual charges, including fines for absence from lectures and prayers. The form used for the son's quarter bills, issued in 1815 and 1816, separate the amounts owed into the following categories: Steward and Commons, Sizings, Study and Cellar Rent, Instruction, Librarian, Natural History, Episcopal Church, Books, Catalogue and Commencement Dinner, Repairs, Sweepers, Assessments for delinquency in payment of Quarter Bills, Wood, and Fines. All of the bills are printed forms which were then filled out by hand, by either the steward or the butler, and issued to the students. Caleb Gannett was the College steward during both father and son's era. Joshua Paine, William Harris, and Thomas Adams served, successively, as butler during the father's era. Some of the butler's bills are signed by Roger Vose, a student who appears to have been employed by the butler in 1786 and 1787.

" Lines upon the late proceedings of the College Government" collection, 1787-1917

This collection contains various manifestations of a humorous poem, most often called "Lines upon the late proceedings of the College Government," written by classmates John Quincy Adams and John Murray Forbes in 1787. Both Adams and Forbes were members of the class of 1787, and the poem recounts events surrounding the pranks and ensuing punishment of two members of the class behind them, Robert Wier and James Prescott. Wier and Prescott had been caught drinking wine and making "riotous noise," and they were publicly reprimanded by Harvard President Joseph Willard and several professors and tutors, including Eliphalet Pearson, Eleazar James, Jonathan Burr, Nathan Read, and Timothy Lindall Jennison. The poem mocks these authority figures, but it spares Samuel Williams, whom it suggests was the only professor to find their antics humorous.

The worship of the serpent traced throughout the world, and its traditions referred to the events in Paradise : proving the temptation and fall of man by the instrumentality of a serpent tempter /

Mode of access: Internet.

Old family letters: copied from the originals for Alexander Biddle.

Mode of access: Internet.

Rolfe's Shakespeare /

Another ed. issued simultaneously, with flexible cloth binding (12mo), in series: English classics.

An Answer to the Observations on the Papers relative to the rupture with Spain.

Signatures: [A]² B-E⁴ F².

The century Shakespeare.

T.p. in green and black; illustrated lining papers.

Electromagnetic noise in Robena No.4 Coal Mine /

USBM Working Fund Agreement HO133005.