996 resultados para 875.07 [Sófocles]
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The O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is a predictive parameter for the response of malignant gliomas to alkylating agents such as temozolomide. First clinical trials with temozolomide plus bevacizumab therapy in metastatic melanoma patients are ongoing, although the predictive value of the MGMT promoter methylation status in this setting remains unclear. We assessed MGMT promoter methylation in formalin-fixed, primary tumor tissue of metastatic melanoma patients treated with first-line temozolomide and bevacizumab from the trial SAKK 50/07 by methylation-specific polymerase chain reaction. In addition, the MGMT expression levels were also analyzed by MGMT immunohistochemistry. Eleven of 42 primary melanomas (26%) revealed a methylated MGMT promoter. Promoter methylation was significantly associated with response rates CR + PR versus SD + PD according to RECIST (response evaluation criteria in solid tumors) (p<0.05) with a trend to prolonged median progression-free survival (8.1 versus 3.4 months, p>0.05). Immunohistochemically different protein expression patterns with heterogeneous and homogeneous nuclear MGMT expression were identified. Negative MGMT expression levels were associated with overall disease stabilization CR + PR + SD versus PD (p=0.05). There was only a poor correlation between MGMT methylation and lack of MGMT expression. A significant proportion of melanomas have a methylated MGMT promoter. The MGMT promoter methylation status may be a promising predictive marker for temozolomide therapy in metastatic melanoma patients. Larger sample sizes may help to validate significant differences in survival type endpoints.
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Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture. Previously Agri-News
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Abstract This phase II trial treated elderly or frail patients with acute myeloid leukemia (AML) with single-agent subcutaneous azacytidine at 100 mg/m(2), on 5 of 28 days for up to six cycles. Treatment was stopped for lack of response, or continued to progression in responders. The primary endpoint was response within 6 months. A response rate ≥ 34% was considered a positive trial outcome. From September 2008 to April 2010, 45 patients from 10 centers (median age 74 [55-86] years) were accrued. Patients received four (1-21) cycles. Best response was complete response/complete response with incomplete recovery of neutrophils and/or platelets (CR/CRi) in eight (18%; 95% confidence interval [CI]: 8-32%.), 0 (0%) partial response (PR), seven (16%) hematologic improvement, 17 (38%) stable disease. Three non-responding patients stopped treatment after six cycles, 31 patients stopped early and 11 patients continued treatment for 8-21 cycles. Adverse events (grade ≥ III) were infections (n = 13), febrile neutropenia (n = 8), thrombocytopenia (n = 7), dyspnea (p = 6), bleeding (n = 5) and anemia (n = 4). Median overall survival was 6 months. Peripheral blood blast counts, grouped at 30%, had a borderline significant association with response (p = 0.07). This modified azacytidine schedule is feasible for elderly or frail patients with AML in an outpatient setting with moderate, mainly hematologic, toxicity and response in a proportion of patients, although the primary objective was not reached.
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Helsinki 1900
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Helsinki 1900
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[cat] ¿Podem convertir l’dip rei de Sfocles en una histria d’amor com ho fa Berkoff a Greek?. Tot i que alguns crtics llegeixen Greek noms com un drama provocador que de cap manera intenta justificar l’incest, directors, actors i crtics resten finalment captivats per la impactant histria d’amor entre Eddy i la seva esposa-mare. Aix demostraria que l’adaptaci de Berkoff, pensada per a il·lustrar la degradaci social de la Gran Bretanya dels 80s, esdev una proposta arriscada, car significa negar de fet la conscincia trgica dels homes i dones contemporanis. Tanmateix, si aquest s el cas, lectors i espectadors, a banda de l’indubtable plaer d’assistir a la representaci de Greek, poden preguntar-se, fins i tot des d’una perspectiva no fonamentalista de la tradici clssica, si t sentit inspirar-se en el text de Sfocles, el qual mostra precisament la gran conscincia trgica dels grecs.
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En aquests ltims anys, sn moltes les empreses que han optat per la utilitzaci de sistemes de gesti normalitzats, per a garantir la rendibilitat i fiabilitat dels resultats de la implantaci del sistema de gesti en qesti. A la dcada dels 90 va ser quan la implantaci de sistemes de gesti va comenar a ser important en la majoria de sectors econmics. L’evoluci en els sistemes de gesti a trets generals va iniciar-se primerament en l’mbit de la qualitat, seguidament en la gesti ambiental i en ltima instncia en la prevenci de riscos laborals. Aquests tres tipus de sistemes de gesti, en els ltims anys s’han anat integrant, de manera que s’han redut els recursos i els esforos emprats en la gesti, millorant significativament l’eficcia i l’eficincia d’aquests sistemes. L’objectiu principal que persegueix aquest projecte, s definir un sistema de gesti que permeti a l’empresa conduir les seves activitats de forma simplificada i ordenada, i que alhora faciliti la informaci necessria per a corregir i millorar les activitats. Un altre objectiu que pretn aconseguir aquest projecte, s el de dissenyar un SGI que aprofiti les sinrgies generades en els diferents mbits de la prpia empresa i fomenti les interaccions entre els diferents nivells de l’organitzaci. En conseqncia, millorar de forma important els fluxos d’informaci dins de l’empresa minimitzant els esforos i la prdua d’informaci. El mtode escollit per a la implantaci del SGI, ha estat la Gesti per Processos, la qual es basa en la definici i seguiment dels processos de l’empresa, partint de les necessitats del client i acabant quan aquestes estan satisfetes. En conclusi, a la finalitzaci del present projecte s’obtindr un SGI, amb tots els processos de l’empresa definits i implantats, que doni compliment a les normes UNEEN-ISO 9001:00, UNE-EN-ISO 14001:04 i OHSAS 18001:07. Aquest SGI, que s’ha realitzat des d’un punt de vista documental i teric, suposar una millora de l’eficcia operativa dels processos i una important millora competitiva de l’empresa.
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Suomen metsteollisuus el voimakasta uusiutumis- ja murrosvaihetta, joka ilmenee muutoksina yksittisten tehtaiden ja tehdasintegraattien toiminnassa. Monia yksikkj on poistunut tuotannosta ja tuotannon painotusta on muutettu. Toisaalta metsteollisuus on suuntaamassa uusille aloille, jolloin tuotteina voivat olla esimerkiksi erilaiset biopolttoaineet, kemianteollisuuden raaka-aineet ja uuden sukupolven paperi- ja kartonkituotteet. Metsteollisuuden muuttuminen ja laitosten monimutkaistuminen sek jatkuvasti lisntyv tiedontarve asettavat yh suurempia vaatimuksia sek toiminnanharjoittajien ympristvastaaville ett viranomaisille. Hallinnon jatkuva muutos ja niukkenevat voimavarat voivat johtaa siihen, ett kytnnn lupa- ja valvontatyhn j yh vhemmn aikaa. Kaakkois-Suomen ELY-keskuksen koordinoima hanke ”Metsteollisuuden ympriststrategia vuoteen 2020 - hallinnon nkkulma” pyrkii vastaamaan edell mainittuihin haasteisiin strategiatyn avulla. Hankkeen tarkoituksena oli tarkastella metsteollisuuden ympristnkkohtia niist lhtkohdista, joihin yritys voi vaikuttaa raaka-aineen tulosta tehtaalle ja tuotteen lhdst tehtaalta sek tehtaan perustamisesta sulkemiseen ja jlkihoitoon asti. Tavoitteena oli mritell toiminnoille toimiva ympriststrategia. Strategiassa pyrittiin lytmn yhteisymmrrys toiminnanharjoittajan ja viranomaisen kanssa mm. siit, miten otetaan kyttn parhaat kytnnt niin teollisuudessa kuin hallinnossakin, toimitaan uusien BAT-, IED- ja vesienhoitoperiaatteiden mukaisesti sek edistetn kestvn kehityksen mukaisten tuotteiden markkinoille tuloa ja otetaan ennakointi tavaksi -lhtkohta kyttn kaikessa toiminnassa. Hanketyss esille nousseet haasteet ryhmiteltiin aihelueittain kolmeksi pkohdaksi trkeysjrjestyksess: viranomaisen ja teollisuuden tiedonkulun ja tietmyksen parantaminen, lupa-, valvonta- ja hallintoprosessien parantaminen sek uusien haasteiden kartoittaminen ja niihin reagointi. Haasteiden ratkaisukeinoiksi etsittiin kytnnn toimenpiteit sek mriteltiin niille vastuutahot. Toimenpiteiksi esitettiin mm. viranomaisen ja teollisuuden yhteisi koulutuspivi, asiantuntijapaneelin perustamista sek lupamrysten antamista mys tehtaan tai tuotantoyksikn sulkemisen tai muuttamisen varalle. Riittvien resurssien ja tietotaidon turvaaminen niin hallinnossa kuin teollisuudessa on ehdoton edellytys toimenpiteiden onnistumiselle
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Invokaatio: D.D.
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Variantti B.
