1000 resultados para 21
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The presence of Gm(1,2,4,10,21) and Km(1) factors in vitreous humor taken from human corpses was investigated. The results revealed a good agreement between the factors detected in this biological material and in blood. Their presence in vitreous humor is independent of the secretor type.
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Current applications of cardiac magnetic resonance (CMR) imaging offer a wide spectrum of indications in the setting of acute cardiac care. In particular, CMR is helpful for the differential diagnosis of chest pain by detection of myocarditis and pericarditis. Also, takotsubo cardiomyopathy and acute aortic diseases can be evaluated by CMR and are important differential diagnoses in patients with acute chest pain. In patients with restricted windows for echocardiography, CMR is the method of choice to evaluate complications of acute myocardial infarction (AMI). In AMI, CMR allows for a unique characterization of myocardial damage by quantifying necrosis, microvascular obstruction, oedema (=area at risk), and haemorrhage. These capabilities will help us to understand better the pathophysiological events during infarction and will also allow to assess new treatment strategies in AMI. To what extent the information on tissue damage will guide patient management is not yet clear and further research in this field is warranted. In the near future, CMR will certainly become more routine in acute cardiac care units, as manufacturers are now focusing strongly on this aspect of user-friendliness. Finally, in the next decade or so, MRI of other nuclei such as fluorine and carbon might become a clinical reality, which would allow for metabolic and targeted molecular imaging with excellent sensitivity and specificity
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Aquest projecte és un estudi teòric exhaustiu sobre l’educació ambiental i la seva inserció en el currículum escolar, així com de la gestió ambiental en l’àmbit educatiu i “ecoauditoria escolar”. Es busca d’ aquesta manera una base sòlida per a poder definir i concretar un programa per a l’ambientalització de centres educatius d’ educació infantil, primària i secundària de la Comunitat Valenciana, que ajudi i faciliti la incorporació d’una nova dimensió ambiental a les escoles
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This retrospective study (April-September 2003) was designed to investigate the roles of the main viruses responsible for cases of acute infantile gastroenteritis in hospitalised children up to two years of age. The viruses were identified in 64.7% (88/136) of the cases and the detection rates of rotavirus A (RVA), norovirus (NoV) and astrovirus were 41.9% (57/136), 30.3% (24/79) and 12.7% (7/55), respectively. RVA and NoV were detected in 20 of the 24 reported nosocomial infection cases. This study identified the first circulation of the genotype NoV GII.21 in Brazil and highlights the need to establish differential diagnoses through active laboratorial surveillance.
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[Vente. Livres. 1859-07-19 - 1859-07-22]
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We report on the medical history of a Caucasian smoker woman diagnosed with a stage IV NSCLC adenocarcinoma, characterized by a rare epidermal growth factor receptor (EGFR) point mutation in exon 21 codon 843 (p.V843I/c.2527G>A/COSMIC ID 85894). This genetic alteration revealed to be germline, after its presence was demonstrated in chondroblasts from the bone biopsy. While it is the first description of germline V843I mutation without concomitant additional known EGFR activating mutation, we modeled the EGFR ATP catalytic domain in complex with ATP, gefitinib and erlotinib using computer-aided approaches to estimate possible changes in affinity upon the V843I mutation.
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Das Management von öffentlichen Organisationen hat sich in den letzen drei, vier Jahrzehnten beachtlich weiterentwickelt. Stichworte sind: verstärkte Ergebnisorientierung, grössere Autonomie bezüglich der Nützung der Ressourcen und der Prioritätensetzung, gesteigerte Ansprüche hinsichtlich der Rechenschaftslegung (Accountability), das gestiegene Interesse der Bürger und Medien an Entscheidungen und Tätigkeiten der öffentlichen Hand usw. Managementmethoden, die teils aus der Privatwirtschaft stammen, teils jedoch speziell für den öffentlichen Sektor entwickelt wurden, vervollständigen die Palette an Instrumenten, die den Public Managern heute zur Verfügung stehen. Dabei spielt die Kommunikation eine wichtige Rolle - sowohl innerhalb der Organisationen selbst wie Auch gegenüber der Gesamtheit ihrer Anspruchsgruppen und der Gesellschaft als Ganzes. Von den Verantwortlichen der öffentlichen Hand wird zunehmend erwartet, dass sie die Probleme und Herausforderungen der Politik offen darlegen, getroffene Entscheidungen erklären, die dazu benötigten Mittel rechtfertigen und die Bedürfnisse und Anforderungen der Leistungsempfänger berücksichtigen.
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Référence bibliographique : Rol, 57735
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