~(146)Tb的能级结构研究

利用能量为161—175MeV的~(32)S束流,通过反应~(118)Sn(~(32)S,1p3n)~(146)Tb研究了双奇核~(146)Tb的高自旋态能级结构。实验进行了γ射线的激发函数、γ射线的各向异性度、X-γ和γ-γ-t符合测量。基于这些测量结果,建立了激发能达8390kev的~(146)Tb核的能级纲图,其中包括新发现的41条γ射线和新建立的27个能级,并指定了~(146)Tb新发现能级的自旋值。用一个h_(11/2)价质子和一个h_(11/2)~(-1)价中子空穴耦合、πh_(11/2)υh_(11/2)~(-1)与~(146)Gd核实激发态的耦合对~(146)Tb的能级结构进行了定性地讨论。

Properties of the beta-delayed proton decay of Ho-146

The proton-rich isotope Ho-148 was produced via the fusion-evaporation reaction Mo-92 (Ni-58, 3p1n). The beta-delayed proton decay of Ho-146 was studied by proton-gamma coincidence measurements using a He-jet tape transport system. The gamma-transitions in Tb-145 following the proton emissions were observed, and the beta-delayed proton branching ratios to the final states in the grand-daughter nucleus Tb-145 were determined. According to the relative branching ratios, the ground-state spin of Ho-146 has been proposed and the possible configuration discussed.

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethality induced following heterologous BRCA1 expression. A genome-wide screen in the diploid deletion collection combined with a screen of ionizing radiation sensitive gene deletions identified mutants that permit growth in the presence of BRCA1. These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1). Strikingly, BRCA1 interacted with the phosphorylated RNA polymerase II (RNAPII) carboxy terminal domain (P-CTD), phosphorylated in the pattern specified by the CTDK-I kinase, to induce DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD. Significantly, breast cancer associated BRCT domain defects in BRCA1 that suppressed P-CTD cleavage and lethality in yeast also suppressed the physical interaction of BRCA1 with human SPT5 in breast epithelial cells, thus confirming SPT5 as a relevant target of BRCA1 interaction. Furthermore, enhanced P-CTD cleavage was observed in both yeast and human breast cells following UV-irradiation indicating a conserved eukaryotic damage response. Moreover, P-CTD cleavage in breast epithelial cells was BRCA1-dependent since damage-induced P-CTD cleavage was only observed in the mutant BRCA1 cell line HCC1937 following ectopic expression of wild type BRCA1. Finally, BRCA1, SPT5 and hyperphosphorylated RPB1 form a complex that was rapidly degraded following MMS treatment in wild type but not BRCA1 mutant breast cells. These results extend the mechanistic links between BRCA1 and transcriptional consequences in response to DNA damage and suggest an important role for RNAPII P-CTD cleavage in BRCA1-mediated cancer suppression.

Optical and infrared photometry of the Type IInSN1998S: days 11-146

We present contemporaneous optical and infrared (IR) photometric observations of the Type IIn SN 1998S covering the period between 11 and 146 d after discovery. The IR data constitute the first ever IR light curves of a Type IIn supernova. We use blackbody and spline fits to the photometry to examine the luminosity evolution. During the first 2-3 months, the luminosity is dominated by the release of shock-deposited energy in the ejecta. After similar to 100 d the luminosity is powered mostly by the deposition of radioactive decay energy from 0.15 +/-0.05 M-. of Ni-56 which was produced in the explosion. We also report the discovery of an astonishingly high IR excess, K-L'=2.5, that was present at day 130. We interpret this as being due to thermal emission from dust grains in the vicinity of the supernova. We argue that to produce such a high IR luminosity so soon after the explosion, the dust must be pre-existing and so is located in the circumstellar medium of the progenitor. The dust could be heated either by the UV/optical flash (IR echo) or by the X-rays from the interaction of the ejecta with the circumstellar material.

Français 146

Contient : 1° Complainte d'amour ; 2° Le Roman de Fauvel, par « FRANÇOIS DE RUES » et « CHAILLOU DE PESTAIN », interpolé de chansons notées, motets, ballades, rondeaux, etc ; 3° « Plusieurs Diz de mestre GEOFFROI DE PARIS », à savoir ; 1 « Premier avisemens pour le roy Loys » ; 2 « Du Roy Phellippe que ore regne » ; 3 « Des Alliez, en latin » ; 4 Un Songe ; 5 « Des Alliez, en françois » ; 6 « De la Comete et de l'eclipse, et de la lune et du soulail » ; 7 « La Desputaison de l'eglise de Romme et de l'eglise de France pour le siege du pape » ; 4° Trente trois Ballades, rondeaux, etc., de « JEHANNOT DE L'ESCUREL » ; 5° Chronique rimée de 1300 à 1316

Français 146

Contient : 1° Complainte d'amour ; 2° Le Roman de Fauvel, par « FRANÇOIS DE RUES » et « CHAILLOU DE PESTAIN », interpolé de chansons notées, motets, ballades, rondeaux, etc ; 3° « Plusieurs Diz de mestre GEOFFROI DE PARIS », à savoir ; 1 « Premier avisemens pour le roy Loys » ; 2 « Du Roy Phellippe que ore regne » ; 3 « Des Alliez, en latin » ; 4 Un Songe ; 5 « Des Alliez, en françois » ; 6 « De la Comete et de l'eclipse, et de la lune et du soulail » ; 7 « La Desputaison de l'eglise de Romme et de l'eglise de France pour le siege du pape » ; 4° Trente trois Ballades, rondeaux, etc., de « JEHANNOT DE L'ESCUREL » ; 5° Chronique rimée de 1300 à 1316