Tau and neurofilaments in a family with frontotemporal dementia unlinked to chromosome 17q21-22.

A Swiss frontotemporal dementia (FTD) kindred with extrapyramidal-like features and without motor neuron disease shows a brain pathology with ubiquitin-positive but tau-negative inclusions. Tau and neurofilament modifications are now studied here in three recently deceased family members. No major and specific decrease of tau was observed as described by others in, e.g., sporadic cases of FTD with absence of tau-positive inclusions. However, a slight decrease of tau, neurofilament, and synaptic proteins, resulting from frontal atrophy was detected. In parallel, polymorphic markers on chromosome 17q21-22, the centromeric region of chromosome 3 and chromosome 9, were tested. Haplotype analysis showed several recombination events for chromosomes 3 and 17, but patients shared a haplotype on chromosome 9q21-22. However as one of the patients exhibited Alzheimer and vascular dementia pathology with uncertain concomitant FTD, this locus is questionable. Altogether, these data indicate principally that the Swiss kindred is unlinked to locus 17q21-22, and that tau is not at the origin of FTD in this family.

ABD e-News August 22, 2003

Newsletter for State of Iowa Alcohol Beverages Division

Lottery Action, July 22-August 4, 2002, Vol. 9 no. 14

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, September 9-22, 2002 Vol. 9, no. 17

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, November 18-December 1, 2002, Vol. 9 no. 22

Newsletter for Iowa Lottery

21/2/20 [i.e. 22/2/20, Juvisy, championnat de Paris de cross country], Guillemot : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58127

Missing Persons Summary, September 22, 2003

Missing persons summary

22/12/19, roue de la loterie du tirage d'un million : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57283

Les halles [pavillon Baltard, Paris 1er arrondissement], 22/12/19 : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57294