Exudative AMD subtypes and eligibility for treatment with ranibizumab

Purpose To ascertain the proportion of patients with neovascular age-related macular degeneration (AMD) eligible for intravitreal treatment with monoclonal antibodies to vascular endothelial growth factor, on the basis of inclusion criteria used in pivotal clinical trials.

A new route to 1-substituted 2,2,3,3-tetracyanocyclopropanes

2,2,3,3-Tetracyanocyclorpropyl ketones were prepared by reaction of tetracyanoethylene with a-chloro ketones.

A structural analysis of G-quadruplex/ligand interactions

This focused review article discusses in detail, all available high-resolution small molecule ligand/G-quadruplex structural data derived from crystallographic and NMR based techniques, in an attempt to understand key factors in ligand binding and to highlight the biological importance of these complexes. In contrast to duplex DNA, G-quadruplexes are four-stranded nucleic acid structures folded from guanine rich repeat sequences stabilized by the stacking of guanine G-quartets and extensive Watson-Crick/Hoogsteen hydrogen bonding. Thermally stable, these topologies can play a role in telomere regulation and gene expression. The core structures of G-quadruplexes form stable scaffolds while the loops have been shown, by the addition of small molecule ligands, to be sufficiently adaptable to generate new and extended binding platforms for ligands to associate, either by extending G-quartet surfaces or by forming additional planar dinucleotide pairings. Many of these structurally characterised loop rearrangements were totally unexpected opening up new opportunities for the design of selective ligands. However these rearrangements do significantly complicate attempts to rationally design ligands against well defined but unbound topologies, as seen for the series of napthalene diimides complexes. Drawing together previous findings and with the introduction of two new crystallographic quadruplex/ligand structures we aim to expand the understanding of possible structural adaptations available to quadruplexes in the presence of ligands, thereby aiding in the design of new selective entities. (C) 2011 Elsevier Masson SAS. All rights reserved.

Energy storage in electrochemical capacitors: designing functional materials to improve device performance

Electrochemical capacitors, also known as supercapacitors, are becoming increasingly important components in energy storage, although their widespread use has not been attained due to a high cost/ performance ratio. Fundamental research is contributing to lowered costs through the engineering of new materials. Currently the most viable materials used in electrochemical capacitors are biomassderived and polymer-derived activated carbons, although other carbon materials are useful research tools. Metal oxides could result in a step change for electrochemical capacitor technology and is an exciting area of research. The selection of an appropriate electrolyte and electrode structure is fundamental in determining device performance. Although there are still many uncertainties in understanding the underlying mechanisms involved in electrochemical capacitors, genuine progress continues to be made. It is argued that a large, collaborative international research programme is necessary to fully develop the potential of electrochemical capacitors.

Cavitary melanoma of the ciliary body. A study of eight cases

Purpose: The authors present the unique clinical features of cavitary uveal melanoma. Design: Retrospective chart review. Participants: Eight patients with cavitary uveal melanoma. Main Outcome Measures: The clinical, ultrasonographic, and histopathologic features of eight patients with cavitary melanoma of the ciliary body were studied. Results: In all eyes there was a brown ciliary body mass that blocked transmission of light on trans-scleral transillumination. Ocular ultrasonography revealed a large, single hollow cavity (unilocular 'pseudocyst') in five cases and multiple hollow cavities (multilocular 'pseudocyst') in three cases. The cavity occupied a mean of 55% of the entire mass thickness (range, 31%-79%). In five cases, a basal uveal mass was noted on ultrasonography. Four patients underwent tumor resection; one had enucleation, and three had 1251 radioactive plaque treatment. In the five cases confirmed histopathologically, the cavitation was empty, contained erythrocytes, serous fluid, and/or pigment-laden macrophages. In no case was the cavity lined by necrotic tumor, endothelial cells, or epithelial cells. Conclusion: Ciliary body melanoma can develop an intralesional cavity resembling an intraocular cyst. The presence of a solid mass at the base and a thick wall surrounding the cavity can assist in the differentiation of cavitary melanoma from benign cyst.

Solid-state NMR and powder XRD studies of the structure of SAPO-40 upon hydration-dehydration cycles

It is well known that after the removal of the template many porous aluminophosphates and related materials are very sensitive to water.' Depending on the type of structure, reversible or irreversible phase transitions, loss of crystallinity and changes in the coordination of some framework A1 upon rehydration are observed. For example, solid-state NMR shows that the rehydration of SAPO-5 leads to the formation of octahedral Al. Subsequent dehydration restores the initial tetrahedral coordination of Al. Template-free SAPO-37 becomes totally amorphous to X-rays after exposure to water and stays so after subsequent thermal treatment^.,,^ In contrast, Barthomeuf and co-workers have shown recently, that, on hydration, template-free SAPO-34, an analogue of chabasite, shows the opening of some Si-0-A1 bonds, the effect being reversible upon dehydrati~n.T~h e hydrated distorted structure was found to be stable for months with no further modifications and the ordered material could be regenerated by removal of water. Here we wish to report that the structure of template-free SAPO-40 undergoes a similar reversible modification.

O perfil do enoturista: o caso português

Tese de doutoramento, Turismo, Faculdade de Economia, Universidade do Algarve, 2015

The effect of long-chain polyunsaturated fatty acids intake during pregnancy on adiposity of healthy full-term offspring at birth

Objective - The adjusted effect of long-chain polyunsaturated fatty acid (LCPUFA) intake during pregnancy on adiposity at birth of healthy full-term appropriate-for-gestational age neonates was evaluated. Study Design - In a cross-sectional convenience sample of 100 mother and infant dyads, LCPUFA intake during pregnancy was assessed by food frequency questionnaire with nutrient intake calculated using Food Processor Plus. Linear regression models for neonatal body composition measurements, assessed by air displacement plethysmography and anthropometry, were adjusted for maternal LCPUFA intakes, energy and macronutrient intakes, prepregnancy body mass index and gestational weight gain. Result - Positive associations between maternal docosahexaenoic acid intake and ponderal index in male offspring (β=0.165; 95% confidence interval (CI): 0.031–0.299; P=0.017), and between n-6:n-3 LCPUFA ratio intake and fat mass (β=0.021; 95% CI: 0.002–0.041; P=0.034) and percentage of fat mass (β=0.636; 95% CI: 0.125–1.147; P=0.016) in female offspring were found. Conclusion - Using a reliable validated method to assess body composition, adjusted positive associations between maternal docosahexaenoic acid intake and birth size in male offspring and between n-6:n-3 LCPUFA ratio intake and adiposity in female offspring were found, suggesting that maternal LCPUFA intake strongly influences fetal body composition.

Escala de madurez gonadal de anchoveta peruana Engraulis ringens (Jenyns, 1842

En este trabajo, se describe la escala de madurez gonadal macroscópica, validada microscópicamente, de anchoveta peruana Engraulis ringens. Se analizó 1970 gónadas (1251 ovarios, 719 testículos), procedentes del seguimiento de la pesquería pelágica del 2006, 2008, 2009 y 2012 y de cruceros de Evaluación Hidroacústica de Recursos Pelágicos del 2006, 2009 y 2012. La escala establece seis estadios de madurez para hembras y machos: 0 (virginal), I (reposo), II (en maduración), III (maduro), IV (desovante/expulsante), V (recuperación/post expulsante).

L'Écho de Paris

1887/08/21 (Numéro 1251).

Legendarius per circulum anni, pars.

Légendier disposé dans l'ordre du calendrier liturgique du 20 juillet au 25 novembre et contenant les saints suivants: ss. Margarita, Maria Magdelene, Jacobus major ap., Stephanus, Laurentius, Hippolytus, assumptio b. Mariae, Bartholomaeus, Augustinus, Johannes Baptista, Aegidius, nativitas b. Mariae, Gorgonius, Protus et Hyacinthus, exaltatio s. Crucis, Euphemia, Matthaeus, Mauritius, Cosmas et Damianus, Michael archangelus, Hieronymus, Leodegarius, Dionysius, Lucas, Simon et Judas, Martinus, Caecilia, Clemens, Catharina. F. 1-130. Legendarius. F. 1-3v. "... passio sancte Margarete virginis"; cf. B.H.L. n° 5306. F. 3v-6v. "... vita sancte Marie Magdalene" [ODO Cluniacensis abbas, sermo 2, excerptum] (P.L. 133, 714B-719C); cf. B.H.L. n° 5440. F. 6v-8v. "... passio sancti Jacobi [majoris] apostoli" incomplet des lignes finales par lacune matérielle, à partir de "decollandi erant dixit [Jacobus...]" [Virtutes apostolorum, de s. Jacobo majore] (Mombritius, 2a ed., II, 37-40 lig. 15); cf. B.H.L. n° 4057; C.A.N.T. n° 272. F. 9-12. "Inventio sancti Stephani prothomartyris" [LUCIANUS presbyter, interprete AVITO presbytero Bracarensi ]. "Domino venerabili Nimpsio [sic] episcopo... [Julianus exponctué et corrigé en] Lucianus... Revelationem que mihi ostensa est...-... aperire dignatus est..." recensio mixta suivie d'un court épilogue: "Bovem appellatum... declarata sunt"; cf. C.P.L. n° 575; B.H.L. Suppl. n° 7851n (E. Vanderlinden, Rev. des études byzantines, IV, 1946, 190-216, version A'; ne fait pas partie des mss. recensés pour l'édition). F. 12-16. "... passio sancti [Sixti et sancti] Laurentii". "In illo tempore Decius Caesar et Valerianus prefectus jusserunt...-... participati sunt omnes"; cf. B.H.L. Suppl. n° 7801 avec var. incipit et n° 4754. F. 16-18. "... passio sancti Ypoliti et sociorum ejus". "Egressus itaque Ypolitus post tercium diem...-... vivere male et regnare cum Christo "; cf. B.H.L. n° 3961 avec var. incipit et explicit. F. 18-31. "... [sermo] beati Ieronimi in assumptione sancte Virginis" [PASCHASIUS RADBERTUS, De Adsumptione b. Mariae] (C.C.C.M., LVI C 109-162; édité aussi parmi les apocryphes de saint Jérôme, P.L., XXX, 126-147); cf. C.P.L. n° 633, ep. 9 (18-29). F. 29-31. Addition contemporaine : "In vigilia assumptionis beate Marie legatur: Secundum Lucam (Lc 11, 27). [M]agne devocionis et fidei...-... ubera que suxisti" [BEDA, In Lc, l. IV, excerptum] divisé en trois paragraphes, correspondant sans doute à trois leçons (P.L., XCII, 479 C-480 B; C.C.S.L., CXX, 236-237 lig. 213-244) (29). — "Sermo iste legatur in nativitate beate Marie virginis"; cf. infra f. 56v. "[A]pprobate consuetudinis est apud christianos...-... pacta cessare" [FULBERTUS CARNOTENSIS, sermo 4] incomplet de la fin qui a été laissée en blanc (P.L. CXLI, 320-324 A; J.M. Canal, dans Rech. théol. anc. méd., XXX (1963), 56-61 lig. 168); ne fait pas partie des mss. répertoriés par J.M. Canal, ibid., XXIX (1962), 36-37; division marginale en neuf, puis en trois fois trois leçons; en marge du titre, une note difficilement lisible identifie l'auteur: "sermo Fulberti ep. Carnotensis" (29v-31). F. 32-35. "... vita [sic pro passio] sancti Bartholomei apostoli" [Virtutes apostolorum, de s. Bartholomaeo]; cf. B.H.L. Suppl. n° 1002a; C.A.N.T. n° 259. F. 35-49v. "[Vita s.] Augustini episcopi", sans prologue [POSSIDIUS]. "Ex provincia affricana civitate...-... perfruar"; cf. B.H.L. n° 785; C.P.L. n° 358 (35-49a lig. 7); suivi de la liste des livres de s. Augustin dans l'ordre des Retractations : "Libros vero quod edidit hic breviter enumerare vel annotare non omissi. Et hoc indicium librorum omnium sancti Augustini. Contra paganos achademicos [sic] libri III. De beata vita liber I. De ordine sacro libri II. De soliloquiis...-... et gratia liber. Requievit autem... V. kal. septembris..." (C.C.S.L., LVII (1984), 1-4, var.); texte proche du ms. lat. 5276, ff. 136v-137, répertorié par A. Wilmart, Miscellanea Agostiniana, Roma, 1931, 157 (Testi e studi, 2) (49a lig. 7-49v). F. 49v-52v. "Inventio capitis sancti Johannis Baptiste"; cf. B.H.L. n° 4296 (49v-51). — "De translatione ejusdem [Angeriacum]"; cf. B.H.L. n° 4297 (51-52v). F. 52v-56v. "... vita sancti Egidii"; cf. B.H.L. n° 93. F. 56v-59v. "De nativitate sancte Marie". "Petis a me petitiunculam opere...-... prefationem habuisse"; cf. B.H.L. Suppl. n° 5345 (56v a-b lig. 27) ; suivi de: "Petitis a me...-... scribi potuerunt. Igitur beata et gloriosissima semper virgo Maria..-... docuerunt Dominum..." (éd. parmi les apocryphes de s. Jérôme, P.L., XXX, 2a ed., 307-317); cf. B.H.L. n° 5344-5343; C.P.L., n° 633, ep. 50 (56v b lig. 27-59v). L'attribution à Paschase Radbert des deux lettres regroupées en une seule faite par C. Lambot, dans Rev. bénéd., XLVI (1934), 271-282, est réfutée par R. Beyers, dans Rev. Théol. et Philos., CXXII (1990), 171-188. Voir sa nouv. éd. dans CC Apocrypha, 10. F. 59v-61v. "Passio sancti Gorgonii [et Dorothei]; cf. B.H.L. n° 3617. F. 61v-62. "[Passio ss.] Prothi et Jacincti"; cf. B.H.L. n° 6977. F. 62-63v. "De exaltatione sancte Crucis". "Tempore illo postquam Constantino Augusto contra Maxentium..."; cf. B.H.L. n° 4178, avec var. incipit. F. 64-68v. "[Passio s.] Eufemie virginis". "Quinto persecutionis anno Diocletiani...-... Completum est autem martyrium... Prisco proconsule Europe..."; cf. B.H.L. n° 2709, avec var. explicit. F. 68v-72v. "[Passio] sancti Mathei apostoli" [Virtutes apostolorum, de s. Jacobo majore]; cf. C.A.N.T. n° 270; B.H.L. n° 5690, avec var. explicit de l'épilogue: "Zaroes autem...-... passio eorum ostendit". F. 72v-76. "[Passio s.] [Marcii corrigé en] Mauricii con [sic] sociis suis" [s. EUCHERIUS LUGDUNENSIS] sans le prologue; cf. B.H.L. n° 5738; C.P.L. n° 490. F. 76-79v. "[Passio ss.] Cosme et Damiani"; cf. B.H.L. Suppl. n° 1975. F. 79v-80. "[In festivitate s.] Michaelis archangeli". "Angelorum quippe et hominum naturam...-... medicina Dei." [GREGORIUS MAGNUS, Hom. in Ev., 34, excerptum]; C.P.L. n° 1711 (P.L., LXXVI, 1249 C-1251 A, §§ 6, fin-9 début) divisé en 8 paragraphes; une interpolation a été ajoutée dans la marge inférieure du f. 79v par une main contemporaine qui a également numéroté les paragraphes en IX leçons, le texte ajouté formant la lectio IIa : "[N]ovem esse angelorum ordines ad Dei judicia...-... principantur."; il s'agit d'un court extrait du sermon Legimus in ecclesiasticis historiis édité par J. E. Cross, dans Traditio, 33 (1977), 108-109 lig. 41-47 (Beda, Homilia subditia 71, P.L., XCIV, 453 C); cf. C.P.P.M., I, 4046. F. 80-82v. "[Vita s.] Jeronimi presbiteri". "Hieronimus noster [corrigé en: presbiter] in oppido Stridonis...-... etatis sue anno in Domino requievit cui..." extraits de la Vie apocryphe de Gennadius (P.L., XXII, 175-184, passim, avec var.); cf. C.P.L. n° 623; B.H.L. n° 3869; Lambert, B.H.M., IIIA, 630 (80-81b lig. 26); suivi du miracle du lion extrait de la Vie du Ps. Sebastianus Casinensis: "Contigit autem hujusmodi miraculum in monasterio... Quadam namque die ingens leo... - asserendo narrantur" (P.L., XXII, 210 lig. 11-213 lig. 11); cf. C.P.L. n° 622; B.H.L. n° 3872 avec var. incipit; Lambert, B.H.M., IIIA, 630 (81b lig. 26-82v). F. 82v-88v. "[Vita s.] Leodegarii". "Igitur sanctus Leodegarius ex progenie...-... postmodum cecum. ... adnecteret opera ibidem" [URSINUS LOGOGIACENSIS] sans le prologue et incomplet de la fin (C.C.S.L., CXVII, 589-632 lig. 14, avec var.); cf. C.P.L. n° 1079a; B.H.L. n° 4851; suivi d'un court extrait omis à sa place plus haut dans le texte: "Deinde vero ire ceperunt... Dei opera ibidem" (ed. cit., 631 § 31 lig. 3-7). F. 88v-98. "[Passio] sancti Dyonisii martyris", texte incomplet par suite de la perte de 2 ff. entre les ff. 96 et 97, le texte s'arrête à "...fideliter adhe[-rebat]" et reprend à "[Domitia-]no per tres Cesares..." (P.L., CVI, 23-40 C et 48 A-50); cf. B.H.L. n° 2175. F. 98-100v. "[Laudatio s.] Luce evvangeliste". "Gloriosus igitur evvangelista Jhesu Christi Lucas natione Syrus...-... ubique confluunt qui ..." [PAULUS DIACONUS, hom. 59] incomplet du prologue (P.L., XCV, 1530-1535, avec var.); cf. B.H.L. n° 4974, d'après ce ms. F. 100v-106. "[Passio ss.] Symonis et Jude apostolorum" avec l'épilogue [ABDIAS, Virtutes Simonis et Judae Thaddaei]; cf. B.H.L. n° 7750-7751; C.A.N.T. n° 284. F. 106-107v. "[Laudatio] sancti Martini archiepiscopi" [ALCUINUS, De vita s. Martini, pars I]; cf. B.H.L. n° 5625. — GREGORIUS TURONENSIS, De virtutibus s. Martini; cf. B.H.L. n° 5618; seule l'adresse du prologue, introduite par une initiale filigranée, a été copiée au bas du f. 107v, col. b: "Domnis sanctis et in Christi amore dulcissimis fratribus... Gregorius peccator", le texte lui-même manque, soit en raison de la perte du cahier suivant, soit qu'il n'ait pas été copié. F. 108-115v. "[Passio s.] Cecilie virginis et martyris"; cf. B.H.L. Suppl. n° 1495a. F. 115v-118v. "[Passio s.] Clementis pape". [Prologus] "Postquam igitur beatus Petrus apostolus in Antiochia cathedram... -... passio secuta est"; cf. B.H.L. Suppl. n° 1849, d'après ce ms. (115v-116a, lig. 11); — "Tunc sanctus Clemens romane ecclesie episcopus disciplinam...-... Cersone Licie provincie"; C.P.L. n° 2177; B.H.L. n° 1848 (Mombritius, 2a ed., I, 341-344, var. à l'incipit et à l'explicit); suivi de: "Oremus fratres ut Dominus... participes. Per..." (116a, lig. 11-118v). F.118v-130. "[Passio] sancte Katerine virginis et martyris"; cf. B.H.L. n° 1663, sans le prologue. F. 130-130v. Additions. Table des saints contenus dans le volume, XIVe s. (130). — Prière latine en 10 strophes de deux vers, XVe s.: "Jhesu tue matris prece ab Orci me serva nece...-... ab inferi atris" (130v).

Recueil de chartes originales de diverses églises et abbayes des diocèses de Soissons, Noyon et Senlis (1015-1297).

Cathédrale de Soissons, etc. (1139-1315). — Abbayes du Charme-aux-Nonnains (1184-1290), — de Saint-Jean-des-Vignes (XIIe et XIIIe s.), — Val-Secret (1144-1290), — la Barre (1249-1287), — Clairefontaine (XIIIe s.), — Saint-Yved-de-Braine (1213-1283), — Longpont (1273-1280), — Notre-Dame de Soissons (1215-1277), — Saint-Crépin-le-Grand de Soissons (1287-1297), — Saint-Médard de Soissons (1228-1258), — Hôpitaux de Braine, de N.-D.-aux-Nonnains et de Saint-Vaast de Soissons (1205-1296). Diocèse de Noyon. — Église de Saint-Quentin (1015-1295), — abbayes de Biache (1272), — Fervaques (1255-1294), — SaintÉloi-Fontaine (1251), — Saint-Quentin-en-Vermandois (1186), — Saint-Quentin-en-l'Ile (1273), — Trinitaires de Saint-Quentin (1258), — prieuré de Vendeuil (1272). Chapitre et abbaye de Saint-Rémi de Senlis (1232-1285).