Development of T-B cell collaboration in neonatal mice.

The neonatal immune response is impaired during the first weeks after birth. To obtain a better understanding of this immaturity, we investigated the development of T cell interactions with B cells in mice. For this purpose, we analyzed the immune response to three T-dependent antigens in vivo: (i) the polyclonal antibody response induced by vaccinia virus; (ii) the production of polyclonal and specific antibodies following immunization with hapten-carrier conjugates; (iii) the mouse mammary tumor virus superantigen (sAg) response involving an increase in sAg-reactive T cells and induction of polyclonal antibody production. After vaccinia virus injection into neonates, the polyclonal antibody response was similar to that observed in adult mice. The antibody response to hapten-carrier conjugates, however, was delayed and reduced. Injection with sAg-expressing B cells from neonatal or adult mice allowed us to determine whether B cells, T cells or both were implicated in the reduced immune response. In these sAg responses, neonatal T cells were stimulated by both neonatal and adult sAg-presenting B cells but only B cells from adult mice differentiated into IgM- and IgG-secreting plasma cells in the neonatal environment in vivo. Injecting neonatal B cells into adult mice did not induce antibody production. These results demonstrate that the environment of the neonatal lymph node is able to support a T and B cell response, and that immaturity of B cells plays a key role in the reduced immune response observed in the neonate.

Innovation and new business through mutually beneficial collaboration and proactive procurement

ABSTRACT This dissertation focuses on new technology commercialization, innovation and new business development. Industry-based novel technology may achieve commercialization through its transfer to a large research laboratory acting as a lead user and technical partner, and providing the new technology with complementary assets and meaningful initial use in social practice. The research lab benefits from the new technology and innovation through major performance improvements and cost savings. Such mutually beneficial collaboration between the lab and the firm does not require any additional administrative efforts or funds from the lab, yet requires openness to technologies and partner companies that may not be previously known to the lab- Labs achieve the benefits by applying a proactive procurement model that promotes active pre-tender search of new technologies and pre-tender testing and piloting of these technological options. The collaboration works best when based on the development needs of both parties. This means that first of all the lab has significant engineering activity with well-defined technological needs and second, that the firm has advanced prototype technology yet needs further testing, piloting and the initial market and references to achieve the market breakthrough. The empirical evidence of the dissertation is based on a longitudinal multiple-case study with the European Laboratory for Particle Physics. The key theoretical contribution of this study is that large research labs, including basic research, play an important role in product and business development toward the end, rather than front-end, of the innovation process. This also implies that product-orientation and business-orientation can contribute to basic re-search. The study provides practical managerial and policy guidelines on how to initiate and manage mutually beneficial lab-industry collaboration and proactive procurement.

Colombe, 9/11/19, rugby, équipe [de] Périgueux [i. e. le C. A. Périgourdin qui a été battu par le Racing Club de France] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56861

400 mètres relais, équipe gagnante [Colombes, 20/7/19 championnat de France d'athlétisme] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55063

Jeux et enjeux dans l'implantation du programme québécois de dépistage du cancer du sein : l'équipée de deux régions

Ce cas décrit les enjeux politiques soulevés au moment de la mise en oeuvre d'une politique gouvernementale visant l'amélioration des services de santé. [Auteurs]

Équipe de France [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55042

Équipe de France [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55043

Hemmi [vainqueur] 100 mètres plat et 200 mètres et de l'équipe relais du 400 mètres [Colombes, 20/7/19 championnat de France d'athlétisme] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55062

Équipe d'Italie [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55039

Équipe d'Australie [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55037

Équipe de Cambridge [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55036

Équipe d'Australie [épreuves d'aviron dans le bassin de Saint-Cloud-Suresnes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55040

Parc des Princes, 9/11/19, rugby, équipe du Stade Français [qui a battu l'équipe de Nantes] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56859