Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.

Novel alpha-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group=4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.

Listautumattomanyrityksen arvonmääritys sukupolvenvaihdoksessa

Tutkimuksen tarkoituksena on selvittää listautumattoman osakeyhtiön sukupolvenvaihdoksessa esiintyviä vero-oikeudellista säätelyä ja arvonmääritystä, kun sukupolvenvaihdos toteutetaan mahdollisimman alhaisella osakkeen arvolla. Osakkeen arvonmäärittäminen liian alhaiselle tasolle saattaa johtaa lahjaverotukseen. Tutkimuksessa havaittiin, että case yrityksen tapauksessa, verohallinnon mukaisella arvonmäärityksellä ohjeistuksella ja Lee & Swathanin modifioidulla EVA -mallilla saadaan alhaisimmat käyvät arvot sukupolvenvaihdoksen suorittamiseksi. Tutkimus pohjautuu arvonmäärityksen osalta ulkomaalaiseen sekä kotimaiseen taloustieteelliseen kirjallisuuteen ja artikkeleihin. Vero-oikeudellinen säätely pohjautuu suomalaiseen oikeustieteelliseen kirjallisuuteen, artikkeleihin ja verohallinnon asiantuntijoiden haastatteluja. Tutkimuksessa on aineistona käytetty case-yrityksen ja sen toimialan tilinpäätöstietoja. Tässä tutkimuksessa onkäytetty konstruktiivista tutkimusmetodologiaa.

Optimització i implementació del Repositori Obert de la Universitat de Lleida

Fer un estudi d'usabilitat del Repositori Obert de la UdL. El repositori recull, gestiona, difon i preserva les publicacions en format digital i en accés obert derivades de l'activitat acadèmica i investigadora, les publicacions institucionals i altres materials de la comunitat universitària.

Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie

Scrapie is a transmissible spongiform encephalopathy with a wide PrPres dissemination in many non-neural tissues and with high levels of transmissibility within susceptible populations. Mechanisms of transmission are incompletely understood. It is generally assumed that it is horizontally transmitted by direct contact between animals or indirectly through the environment, where scrapie can remain infectious for years. In contrast, in utero vertical transmission has never been demonstrated and has rarely been studied. Recently, the use of the protein misfolding cyclic amplification technique (PMCA) has allowed prion detection in various tissues and excretions in which PrPres levels have been undetectable by traditional assays. The main goal of this study was to detect PrPres in fetal tissues and the amniotic fluid from natural scrapie infected ewes using the PMCA technique. Six fetuses from three infected pregnant ewes in an advanced clinical stage of the disease were included in the study. From each fetus, amniotic fluid, brain, spleen, ileo-cecal valve and retropharyngeal lymph node samples were collected and analyzed using Western blotting and PMCA. Although all samples were negative using Western blotting, PrPres was detected after in vitro amplification. Our results represent the first time the biochemical detection of prions in fetal tissues, suggesting that the in utero transmission of scrapie in natural infected sheep might be possible.

Correlated genetic effects on reproduction define a domestication syndrome in a forest tree.

Compared to natural selection, domestication implies a dramatic change in traits linked to fitness. A number of traits conferring fitness in the wild might be detrimental under domestication, and domesticated species typically differ from their ancestors in a set of traits known as the domestication syndrome. Specifically, trade-offs between growth and reproduction are well established across the tree of life. According to allocation theory, selection for growth rate is expected to indirectly alter life-history reproductive traits, diverting resources from reproduction to growth. Here we tested this hypothesis by examining the genetic change and correlated responses of reproductive traits as a result of selection for timber yield in the tree Pinus pinaster. Phenotypic selection was carried out in a natural population, and progenies from selected trees were compared with those of control trees in a common garden experiment. According to expectations, we detected a genetic change in important life-history traits due to selection. Specifically, threshold sizes for reproduction were much higher and reproductive investment relative to size significantly lower in the selected progenies just after a single artificial selection event. Our study helps to define the domestication syndrome in exploited forest trees and shows that changes affecting developmental pathways are relevant in domestication processes of long-lived plants.

Torneå

Helsingfors : A.W. Gröndahl & A.C. Öhman 1845 : Dresden, Adler u. Dietze

Maamme kirja lukukirja alimmaisille oppilaitoksille Suomessa - [Nimiösivu] - Toinen jakso (0002)

Helsinki : G.W. Edlund 1876

Ny-Carleby

Helsingfors : A.W. Gröndahl & A.C. Öhman 1845 : Dresden, Adler u. Dietze