Determinação de genes mórbidos e drogáveis a partir da construção e análise da rede integrada de interações moleculares entre genes humanos

The discovering process of new morbid genes and new target proteins for drugs have been shown to be very costly and laborious. Having in view cutting costs and speeding up this process, we propose, in this work, a new method to determine the gene druggability score and morbidity score, the probabilities of the protein encoded by the gene have the characteristics that make it a new target for drugs and in case of an alteration in that gene, we observed a phenotype that characterizes a genetic based illness. To determine these characteristics, we built, analyzed and determined the characteristics of the topology of the integrated molecular interactions network among human genes containing physical interactions between proteins, metabolic interactions and interactions of transcriptional regulation, and included other data such as level of gene transcription and cellular localization of the protein encoded by the gene. We tested our model in training sets and achieved results equal or better than the ones achieved by similar methods in the literature. Finally, with the purpose of investigating whether the assigned scores resembles the potential druggabilities and morbities of the previously unclassi ed genes, we looked for evidences in biomedical literature supporting the potential druggability and morbidity status of genes with the 10 highest scores. We found clear evidences for 73% and 90% of potential druggable and morbid genes respectively

Caracterização e origem da composição química da incrustação e simulação de cenários de perda de energia em setor da rede de abastecimento de água da cidade de Rio Claro - SP

The purpose of this work was the inlay’s characterization from the water supply networks of Rio Claro-SP city; as well analyze the influence of network’s aging in the actual system. To do this, some samples of inlays were collected and made chemistry analysis and X-Ray Diffraction Spectrometry. The history of the source water quality was also analyzed, to make possible to known the origins of the inlays. To evaluate the performance of the network, some different scenarios have been simulated, varying the resistance coefficient of the water supply networks of Rio Claro-SP. The characterization results showed that there are basically oxide and hydroxide of iron (magnetite and goethite) and quartz in the inlays, which are materials of high hardness. The hydraulic simulations indicated that the simulated scenarios had a variation of ~2000% in terms of loss of energy

Estudo da acessibilidade aplicado a rodoviária de Aparecida-SP

The aim of this study was to develop a case study of road Aparecida, where it noticed a large movement of people with disabilities who use the road, bound for the city's churches. Another objective was to compare the minimum dimensions established by law, with the dimensions of the spaces (slope of ramps, wide sidewalks, etc.) on the road of Aparecida. Starting from this fact, a study was done on the architectural barriers faced by people with special needs and disabled. It was also made a field survey in order to know the opinion of the users about the accessibility of pregnant elderly and disabled in the road. Technical visits were also made in order to detect sites with access problems with special needs. Also were proposed guidelines for renovation of the building where the road works

Abordagem técnica sobre os aspectos de uma rede social colaborativa

With the advancement of the gaming industry in the market, became evident the need for professionals working in this area. With this in mind, this paper attempts to create an environment where aspirants and professionals in creating games can interact. To get to this point, was built one system based on current technologies, and parad igms of software engineering system. So throughout this monograph the process of the system development is studied, using different technologies, and showing how it can work, the exchange of information and knowledge among the games creation lovers

Projeto de um transdutor binocular utilizando extensometria e aplicação na pesagem rodoviária

With the passage of time, the variety of companies from each branch has gradually grown throughout the country. As a consequence, the logistics to attend to such demand has grown in the same proportion. One factor to highlight about this rapid growth is the increase of freight vehicles roaming the roads, often carrying loads over the limit established by law. At first it may seem that this would not bring any problem, however, note that an excessive number of overloads ends up deteriorating the asphalt, causing ondulations, potholes and other imperfections on the roads, which can cause accidents. In addition, the money spent for the maintenance of the roads is high. Thinking about it, it was established by law a regulation that restricts the weight limit for these vehicles, through axle weighing, subject to a fine. With this control the road floor is preserved for longer, requiring less maintenance expenses. The weighing stations use load cells to display the inferred weight, these cells use strain gages in its construction. The following work presents a methodology to dimension a binocular load cell, its main elements and its dimensioning. Showing how different materials can affect the dimensioning, so that can work satisfactorily. It also presents an overview of how are the parameters for weighing, and fines

A inclusão de crianças com necessidades educacionais especiais na rede regular de ensino: uma perspectiva de respeito às diferenças e desconstrução do preconceito

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Sistema fotovoltaico interligado á rede eletrica no Campus da UNESP-FEG Guaratinguetá

Solar energy can be considered the largest source of energy available on earth and has attracted in recent decades, attention and interest for its rational use. The use of energy sources in a sustainable manner is essential to the survival of future generations, due to the scarcity of natural resources and their exploitation in a disorderly way. Studies related to the applications of renewable sources becomes then relevant, given its great importance as regards the conscious use of resources provided by nature, with the least possible impact on it. The present study presents an evaluation of generation potential and feasibility of implementing a solar photovoltaic connected to the grid and connected to the roofs of some buildings of the Faculty of Engineering of Guaratinguetá - FEG, to supply the demand of electric energy consumption on campus and attempting to inject a possible surplus power generation in local power grid, increasing network capacity and reducing peak loads

Projeto de uma rede de ar comprimido industrial

In this study was shown the historical uses of compressed air by humanity, the general scenario of its uses and the most important steps of a project to set up an industrial network of compressed air, from the selection of a suitable compressor to the design of a distribution network, discussing all the possibilities and their characteristics as well as the feasibility of them. A case study was conducted in a food company where was implemented an industrial compressed air network. Information was collected regarding the consumers points of compressed air, as well as the layout of the new facility, necessary for the development of the distribution system. Two methods were used, analytical and nomogram, which complemented each other to the definition of appropriated tubing, both financially and physically

Políticas culturais, participação e educação: o caso da rede Arte Cultura Rio Claro - SP (2008-2012)

No atual momento as redes sociais, fazendo uso dos meios digitais/virtuais e partindo para ações no real/presencial, têm tido cada vez mais papel político importante nas transformações das relações humanas. Nestas redes há compartilhamentos de diversas informações, documentos e materiais com conteúdos que auxiliam na formação, assimilação e aprendizagem tanto pelos participantes diretos destas redes quanto pelos demais sujeitos e cidadãos influenciados pelas ideais elaboradas a partir destas redes. Este projeto pretende estudar a rede “Arte Cultura Rio Claro” no período 2008 a 2012 tendo como foco a realização da I Conferência Municipal de Política Cultural e as lutas pela criação do Conselho Municipal de Política Cultural. O trabalho abordará: as trocas e compartilhamentos entre os integrantes desta rede, a realização de encontros, reuniões, fóruns; o recebimento do Prêmio do Ministério da Cultura como ‘Articulação da Rede’ e a realização do Projeto “Tuxáua”; a realização das pré-conferências e 1ª Conferência Municipal de Política Cultural; a criação do Conselho Municipal de Política Cultural; entre outros. O objetivo do projeto é avaliar a rede como processo participativo, mostrando a relevância da política cultural para a educação não-formal de uma comunidade, principalmente por conta das pautas desta rede trazerem tanto a importância de valorizar a diversidade cultural, quanto a importância da participação cidadã nas decisões políticas

Melhor idade na rede: uma visão da inclusão digital do idoso : estudo do caso da Universidade Aberta à Terceira Idade da UNESP Bauru

In the information society, the use of Technologies has been incorporated to our quotidian. The use of personal computers and internet, however, does not reach to all the individuals, creating the problem of digital exclusion. Nowadays, many inclusion politics are being developed to diminish the digital abyss in society, in a way to enable a plural access to the internet. Between these initiatives, we highlight the projects of digital inclusion among the elderly, slice of the population that grows more each day and seek quality of life, social reinclusion and health. In this context, the open universities for the elderly bring to the aged courses and workshops, in order to encourage the activity in this age group. An example of this idea is the Unati of UNESP Bauru, that develops the project “Terceira Idade Digital”. This work aims to analyze the relation between the elderly with certain technologies, apart from showing the digital inclusion scenario, with its delays and progresses