O ENSINO DA FILOSOFIA NAS DIRETRIZES DE JEAN MAUGÜÉ E NO HISTORICISMO DO PENSAMENTO DE JOÃO DA CRUZ COSTA: PIONEIRISMO NA UNIVERDSIDADE DE SÃO PAULO

O presente estudo foi desenvolvido com o objetivo de refletir a relevância do Ensino de Filosofia no contexto histórico brasileiro em consonância conjectural paulistana. Apontamos através do Decreto nro. 6.283 de 25 de janeiro de 1934, o qual instituiu-se sendo a primeira Universidade brasileira (Universidade de São Paulo) nas palavras de Vita “iniciativa pioneira no Brasil” (1969, p.16). Inspirada no modelo universitário tradicional da cultura filosófica francesa, a Faculdade de Filosofia, Ciências e Letras adotou desde os seus contíguos metodológicos aos procedimentos intelectivos, favorecendo o desenvolvimento da interdisciplinaridade da formação cultural. Uma confluência marcada por intensos envolvimentos ideológicos estruturados do progresso moderno, infundindo competências científicas na faculdade profissional incorporada à universidade, bem como formar professores para o ensino secundário (SCHWARTZMAN, 2006, p.163). Sendo assim, a Faculdade de Filosofia seria o núcleo propulsor. Porém, o modelo centralizador de pensar o Ensino da Filosofia, a atribui uma superioridade técnica intelectual e saber acumulado, pouco distingue da competência escolar conquistada em outros países, pelo potencial formativo dos professores filósofos Jean Maugüé (1955,1982) e João da Cruz Costa (1945, 1960, 1961,1967). Mauguë aponta-nos quão a formação em Filosofia está diretamente atribuída ao docente e ao aluno, que a ela se dedica. Pela obra Ensino de Filosofia e Diretrizes, ele apresenta-nos também a concepção de docência: o docente-intelectual, comprometido com a (re) construção dos significados epistemológicos, legitimados por uma prática pedagógica entre o já conhecido e ao conhecer, ou seja, entre o ensinado e ao ensinar. Nesse sentido, é notável que os argumentos do docente e do filósofo se imbricam, ao ponto de serem confundidos e potencializados durante a formação. Assim, Cruz Costa, também trabalha, quando assume a cátedra, porém ressalta que o processo formativo adquire sentido pela História das Ideias como construção do pensamento filosófico e, portanto, o ensino se faz quando se toma consciência da concentricidade histórica, ideias que lhe concede significado conjugado às técnicas de erudição, o que fez advertir aos seus alunos para as vicissitudes pelas quais passaram em nossa terra, as correntes filosóficas estrangeiras, e, sobretudo, para a curiosa significação que elas têm apresentado no envolver de nossa história (VITA, 1950, p.22). O conhecimento histórico é o caminho norteador a ser percorrido, necessário ao devir humano, isto é, a conciliação entre o conhecimento teórico e as condições históricas.

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30–50% higher in men than in women) decreases with age, toward ≈20–10% of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neurotransmitter receptors. Whether there is a cause-to-effect relationship between the decreasing levels of DHEAS with age and physiological and pathological manifestations of aging is still undecided, but this is of obvious theoretical and practical interest in view of the easy restoration by DHEA administration. Here we report on 622 subjects over 65 years of age, studied for the 4 years since DHEAS baseline values had been obtained, in the frame of the PAQUID program, analyzing the functional, psychological, and mental status of a community-based population in the south-west of France. We confirm the continuing decrease of DHEAS serum concentration with age, more in men than in women, even if men retain higher levels. Significantly lower values of baseline DHEAS were recorded in women in cases of functional limitation (Instrumental Activities of Daily Living), confinement, dyspnea, depressive symptomatology, poor subjective perception of health and life satisfaction, and usage of various medications. In men, there was a trend for the same correlations, even though not statistically significant in most categories. No differences in DHEAS levels were found in cases of incident dementia in the following 4 years. In men (but not in women), lower DHEAS was significantly associated with increased short-term mortality at 2 and 4 years after baseline measurement. These results, statistically established by taking into account corrections for age, sex, and health indicators, suggest the need for further careful trials of the administration of replacement doses of DHEA in aging humans. Indeed, the first noted results of such “treatment” are consistent with correlations observed here between functional and psychological status and endogenous steroid serum concentrations.

Comparative Biochemistry of the Oxidative Burst Produced by Rose and French Bean Cells Reveals Two Distinct Mechanisms1

Cultured cells of rose (Rosa damascena) treated with an elicitor derived from Phytophthora spp. and suspension-cultured cells of French bean (Phaseolus vulgaris) treated with an elicitor derived from the cell walls of Colletotrichum lindemuthianum both produced H2O2. It has been hypothesized that in rose cells H2O2 is produced by a plasma membrane NAD(P)H oxidase (superoxide synthase), whereas in bean cells H2O2 is derived directly from cell wall peroxidases following extracellular alkalinization and the appearance of a reductant. In the rose/Phytophthora spp. system treated with N,N-diethyldithiocarbamate, superoxide was detected by a N,N′-dimethyl-9,9′-biacridium dinitrate-dependent chemiluminescence; in contrast, in the bean/C. lindemuthianum system, no superoxide was detected, with or without N,N-diethyldithiocarbamate. When rose cells were washed free of medium (containing cell wall peroxidase) and then treated with Phytophthora spp. elicitor, they accumulated a higher maximum concentration of H2O2 than when treated without the washing procedure. In contrast, a washing treatment reduced the H2O2 accumulated by French bean cells treated with C. lindemuthianum elicitor. Rose cells produced reductant capable of stimulating horseradish (Armoracia lapathifolia) peroxidase to form H2O2 but did not have a peroxidase capable of forming H2O2 in the presence of reductant. Rose and French bean cells thus appear to be responding by different mechanisms to generate the oxidative burst.