Action for a cleaner tomorrow : K-1

Action for a cleaner tomorrow, a South Carolina environmental curriculum supplement has been developed to teach the children of South Carolina and, ultimately, their parents to think about their daily habits and to make environmentally responsible choices. This curriculum supplement tries to reflect the environmental issues facing the world today with a particular emphasis on South Carolina’s concerns and goals. This document deals with grades K-1.

Annual message of his excellency Robert K. Scott, Governor of South Carolina, to the General Assembly, at the regular session, commencing November 28, 1871

This speech was delivered to by the Governor to give the general assembly information of the condition of the state and give them recommendations to consider measures that the Governor deems necessary or expedient. He provides the information regarding the state debt, taxes, and bonded debt. He describes the financial agent of the state as well as the expenditures of the state government.

Message of Robert K. Scott, Governor of South Carolina to the General Assembly, November 24, 1869

This speech was addressed to the people of the Senate and House of Representatives. It was delivered to inform them of the progress over the past year made to place the finances of the state on a firm and healthy basis. He gives a report on all departments and projects funded by the government in the past year.

Suggestions by the South Carolina Citizens’ Educational Association for the observance of American Education Week, December 3-9, 1922

The bulletin presents an outline for an educational talk for speakers promoting education in South Carolina.

K'cidade : um modo de viver a intervenção comunitária

Relatório de estágio de mestrado, Ciências da Educação (Formação de Adultos), Universidade de Lisboa, Instituto de Educação, 2011

Cost-Effectiveness of Non-Vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation in Portugal

INTRODUCTION AND OBJECTIVES:Recently, three novel non-vitamin K antagonist oral anticoagulants received approval for reimbursement in Portugal for patients with non-valvular atrial fibrillation (AF). It is therefore important to evaluate the relative cost-effectiveness of these new oral anticoagulants in Portuguese AF patients. METHODS: A Markov model was used to analyze disease progression over a lifetime horizon. Relative efficacy data for stroke (ischemic and hemorrhagic), bleeding (intracranial, other major bleeding and clinically relevant non-major bleeding), myocardial infarction and treatment discontinuation were obtained by pairwise indirect comparisons between apixaban, dabigatran and rivaroxaban using warfarin as a common comparator. Data on resource use were obtained from the database of diagnosis-related groups and an expert panel. Model outputs included life years gained, quality-adjusted life years (QALYs), direct healthcare costs and incremental cost-effectiveness ratios (ICERs). RESULTS:Apixaban provided the most life years gained and QALYs. The ICERs of apixaban compared to warfarin and dabigatran were €5529/QALY and €9163/QALY, respectively. Apixaban was dominant over rivaroxaban (greater health gains and lower costs). The results were robust over a wide range of inputs in sensitivity analyses. Apixaban had a 70% probability of being cost-effective (at a threshold of €20 000/QALY) compared to all the other therapeutic options. CONCLUSIONS:Apixaban is a cost-effective alternative to warfarin and dabigatran and is dominant over rivaroxaban in AF patients from the perspective of the Portuguese national healthcare system. These conclusions are based on indirect comparisons, but despite this limitation, the information is useful for healthcare decision-makers.