A supervised cooperative learning system for early detection of language disorders

The Quality of Life of a person may depend on early attention to his neurodevel-opment disorders in childhood. Identification of language disorders under the age of six years old can speed up required diagnosis and/or treatment processes. This paper details the enhancement of a Clinical Decision Support System (CDSS) aimed to assist pediatricians and language therapists at early identification and re-ferral of language disorders. The system helps to fine tune the Knowledge Base of Language Delays (KBLD) that was already developed and validated in clinical routine with 146 children. Medical experts supported the construction of Gades CDSS by getting scientific consensus from literature and fifteen years of regis-tered use cases of children with language disorders. The current research focuses on an innovative cooperative model that allows the evolution of the KBLD of Gades through the supervised evaluation of the CDSS learnings with experts¿ feedback. The deployment of the resulting system is being assessed under a mul-tidisciplinary team of seven experts from the fields of speech therapist, neonatol-ogy, pediatrics, and neurology.

The Use of Patents to Assess National Innovation Systems: Evidences from Spanish Biotechnology

Spain’s economy recorded a high rate of growth from the mid-1990s onwards. At the same time, the resources allocated to Research and Development (R&D) grew at a much faster pace than in other European Union (EU) countries. Spain’s growth recorded an average rate of 2.93% from the early 1990s to 2004. Over the same period, the average growth in the EU was 0.46%. This circumstance, together with several sound policy decisions implemented between 2004 and 2009, ushered in a “golden age of Spanish biotechnology”. In terms of the national patent licenses issued by the Spanish Patent and Trademark Office (SPTO) between 2004 and 2009, the number in biotechnology grew from 84 to 151. However, the current economic situation in Spain, along with a series of political decisions taken over the past two or three years to cut spending on R&D, predicts a sharp downturn in the performance of Spanish biotechnology. This scenario makes Spain one of the best places to study the successes and failures of the management of science and allows transfer this experience to the other international regions. We need to analyze the influence of political decisions as a major factor with a bearing on the quality of science. Using patents as an indicator of scientific development, this paper analyzes the evolution of the biotechnology sector in Spain and its relationship with scientific policy and the management of R&D.

La arquitectura religiosa de Luis Cubillo de Arteaga (1954-1974)

Esta Tesis Doctoral viene a cubrir el vacío existente referido a la arquitectura religiosa de Luis Cubillo de Arteaga, arquitecto conocido fundamentalmente por su aportación a la vivienda social madrileña en los años 50 y 60, pero con una abundante obra sacra. Para ello se ha estudiado la totalidad de su producción, que abarca desde 1954 hasta 1974. La Tesis analiza su arquitectura religiosa desde varios puntos de vista, que incluyen la implantación de los edificios y sus aspectos formales, constructivos y tipológicos, estos últimos especialmente destacados tras las directrices emanadas del Concilio Vaticano II. Previamente se analizan cuatro ámbitos relevantes en la arquitectura religiosa de Cubillo. En primer lugar se estudia la labor de la Dirección General de Asuntos Eclesiásticos, a la que estaba adscrito el arquitecto y para la que realizó sus primeros trabajos. Dentro de ella se expone la evolución del modelo de Seminario entre los años 40 y 60, para analizar la relevancia de la propuesta de Cubillo para el Seminario de Castellón. A continuación se trata la participación de Cubillo en la construcción de la periferia de Madrid, aunque no referida a sus conocidos trabajos sobre vivienda social, sino a los edificios dotacionales. Así mismo se expone una iniciativa hasta ahora inédita de la Comisaría de Ordenación Urbana de Madrid para dotar de centros parroquiales a los nuevos barrios. Un tercer bloque estudia un tema recurrente a finales de los años 50, la integración de las artes en la nueva arquitectura religiosa, propiciada principalmente por José Luis Fernández del Amo. En el caso de Cubillo, las colaboraciones más notables y objeto de estudio en esta Tesis, fueron las realizadas con los artistas Arcadio Blasco y José Luis Sánchez. Por último se describe la situación de la iglesia madrileña posconciliar y su plan de construcción de nuevos templos, en el que jugó un papel muy destacado Cubillo, convertido en arquitecto de confianza de la Oficina Técnica del Arzobispado-------------------------ABSTRACT------------------------------ This Doctoral Thesis fills the emptiness of knowledge about the religious architecture of Luis Cubillo de Arteaga, architect mainly known for his contribution to Madrid's social housing in the 50s and 60s, but with a wide sacred work. To this end it have been studied his entire production, ranging from 1954 to 1974. The thesis discusses his religious architecture from several points of view, including the implementation of the buildings and their formal, constructive and typological aspects, the latter especially important by following the guidelines issued by Vatican II. Previously, four relevant areas in Cubillo’s religious architecture are analyzed. First of all, it’s studied the work of the Department of Ecclesiastical Affairs, to which the architect was assigned and for whom he made his early works. As a part of it, is exposed the evolution of Seminar model between 40s and 60s, to discuss the relevance of Cubillo’s design for the Seminar of Castellón. Next, it´s studied the participation of Cubillo in the construction of the outskirts of Madrid, although not referring to his well known work on social housing, but to the design of the comunitary buildings. It’s also explained an unpublished initiative from Commissariat for Urban Planning of Madrid to provide parish centers to new neighborhoods. A third section examines a recurring theme in the late 50s, the integration of the arts in the new religious architecture, mainly leaded by José Luis Fernández del Amo. For Cubillo, the most notable collaborations, studied in this thesis, were with the artists Arcadio Blasco and José Luis Sánchez. Finally, it´s described the situation of the post-conciliar church in Madrid and its plan to build new temples, with a prominent role of Cubillo, that became in trusted architect of the Technical Office of the Archbishop.

Optimización de la agitación de un digestor anaerobio mediante mecánica de fluidos computacional

Debido al gran interés existente en el ahorro y recuperación de energía, y en el deseo de obtener productos que permitan usos beneficiosos del fango procedente de la depuración del agua residual, la digestión anaerobia es el proceso de estabilización de uso más extendido. El tiempo de retención de sólidos es un factor clave en el proceso de digestión anaerobia. En base al tiempo de retención de sólidos, se dimensiona el volumen de los digestores anaerobios para así obtener la reducción de materia orgánica deseada, con la correspondiente producción de biogás. La geometría del digestor y su sistema de agitación deben ser adecuados para alcanzar el tiempo de retención de sólidos de diseño. Los primeros trabajos sobre la agitación de los digestores realizaban únicamente experimentos con trazadores y otros métodos de medición. En otros casos, la mezcla era evaluada mediante la producción de biogás. Estas técnicas tenían el gran hándicap de no conocer lo que sucedía realmente dentro del digestor y sólo daban una idea aproximada de su funcionamiento. Mediante aplicación de la mecánica de fluidos computacional (CFD) es posible conocer con detalle las características del fluido objeto de estudio y, por lo tanto, simular perfectamente el movimiento del fango de un digestor anaerobio. En esta tesis se han simulado mediante CFD diferentes digestores a escala real (unos 2000 m3 de volumen) agitados con bomba/s de recirculación para alcanzar los siguientes objetivos: establecer la influencia de la relación entre el diámetro y la altura, de la pendiente de la solera, del número de bombas y del caudal de recirculación en dichos digestores, definir el campo de velocidades en la masa de fango y realizar un análisis energético y económico. Así, es posible conocer mejor cómo funciona el sistema de agitación de un digestor anaerobio a escala real equipado con bomba/s de recirculación. Los resultados obtenidos muestran que una relación diámetro/altura del digestor por encima de 1 empeora la agitación del mismo y que la pendiente en la solera del digestor favorece que la masa de fango esté mejor mezclada, siendo más determinante la esbeltez del tanque que la pendiente de su solera. No obstante, también es necesario elegir adecuadamente los parámetros de diseño del sistema de agitación, en este caso el caudal de recirculación de fango, para obtener una agitación completa sin apenas zonas muertas. En el caso de un digestor con una geometría inadecuada es posible mejorar su agitación aumentando el número de bombas de recirculación y el caudal de las mismas, pero no se llegará a alcanzar una agitación total de la masa de fango debido a su mal diseño original. Anaerobic digestion is the process for waste water treatment sludge stabilization of more widespread use due to the huge interest in saving and recovering energy and the wish to obtain products that allow beneficial uses for the sludge. The solids retention time is a key factor in the anaerobic digestion. Based on the solids retention time, volume anaerobic digester is sized to obtain the desired reduction in organic matter, with the corresponding production of biogas. The geometry of the digester and the stirring system should be adequate to achieve the design solid retention time. Early works on digesters stirring just performed tracer experiments and other measurement methods. In other cases, mixing was evaluated by biogas production. These techniques had the great handicap of not knowing what really happened inside the digester and they only gave a rough idea of its operation. By application of computational fluid dynamics (CFD), it is possible to know in detail the characteristics of the fluid under study and, therefore, simulate perfectly the sludge movement of an anaerobic digester. Different full-scale digesters (about 2000 m3 of volume) agitated with pump/s recirculation have been simulated by CFD in this thesis to achieve the following objectives: to establish the influence of the relationship between the diameter and height, the slope of the bottom, the number of pumps and the recirculation flow in such digesters, to define the velocity field in the mass of sludge and carry out an energy and economic analysis. Thus, it is possible to understand better how the agitation system of a full-scale anaerobic digester equipped with pump/s recirculation works. The results achieved show that a diameter/height ratio of the digester above 1 worsens its stirring and that the slope of the digester bottom favors that the mass of sludge is better mixed, being more decisive the tank slenderness than the slope of its bottom. However, it is also necessary to select properly the design parameters of the agitation system, in this case the sludge recirculation flow rate, for a complete agitation with little dead zones. In the case of a digester with inadequate geometry, its agitation can be improved by increasing the number of recirculation pumps and flow of them, but it will not reach a full agitation of the mass of sludge because of the poor original design.