Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

Na rota da identidade e da alteridade nas obras O útero da casa e A dolorosa raiz do Micondó de Conceição Lima e na Assomada nocturna (poema de N'Zé di Sant'y Águ) de José Luís Hopffer C. Almada

Dissertação de Mestrado em Literaturas Lusófonas Comparadas apresentada à Universidade Aberta

Na rota da identidade e da alteridade nas obras O útero da casa e A dolorosa raiz do Micondó de Conceição Lima e na Assomada nocturna (poema de N'Zé di Sant'y Águ) de José Luís Hopffer C. Almada

Dissertação de Mestrado em Literaturas Lusófonas Comparadas apresentada à Universidade Aberta

Diversity of Pentatomoidea (Hemiptera) in riparian forests of southern Brazil: taller forests, more bugs

Riparian forests are important features of any ecosystem, especially on grassland and savannah vegetation types. However, riparian forests in southernmost Brazil have received much less attention than elsewhere. This is the first quantitative study of pentatomoid (Hemiptera) diversity in the Pampa biome, surveying riparian forests of brooks and rivers in the environs of the municipality of Bagé, Rio Grande do Sul state, southern Brazil. The aim was two-fold: taxonomic characterization of the fauna and a primary ecological study of bug diversity. Sweeping net and beating tray were used to sample trees and shrubs on the border of sampling sites; sampling was carried out during three consecutive days, from March 28th to 30th 2006. Overall 154 individuals of 32 species of Pentatomoidea were captured, almost all species are new records for the local fauna. Taller forest canopy sites had higher abundance overall and higher species richness than shorter forest canopy sites. Of the 32 species, 11 were singletons and four were doubletons. There were no differences for pentatomoid species composition between the two environments differing in vegetation structure. Association to the Pampa biome of the most abundant species found are discussed. Although based on a rapid assessment protocol of faunal inventories, our results add important bioecological information to the pentatomoid fauna of the Pampa biome, especially associated to riparian forests.

Prospección de concha perlífera Pteria sterna en Talara, noviembre 2000

Identifica los principales bancos naturales para conseguir información sobre las poblaciones, densidades y principales características biológicas del recurso concha perla o concha perlífera (Pteria sterna) frente a las costas de Talara, así como sus relaciones y variaciones con el ambiente marino y la actividad extractiva, con el fin de brindar asesoria técnica al Ministerio de Pesquería para el establecimiento de adecuadas medidas de ordenamiento pesquero.

Estado actual de la pesquería de los recursos Tolina (Concholepas concholepas) y caracol (Thais chocolata) en el litoral de Moquegua y Tacna

Se analizan algunos aspectos biométricos y biológicos referidos al estado actual de la pesquería de los recursos chanque o tolina y caracol plomo en el litoral de Moquegua y Tacna basados en los registros de desembarque. El resultado indica que los recursos se encuentran sometidos a una intensa sobreexplotación que afecta su crecimiento poblacional y reclutamiento. Por tanto se requiere el planteamiento de un ordenamiento y manejo pesquero adecuados que garanticen una pesquería sostenida a largo plazo.