The Australian multiple sclerosis (MS) immunotherapy study: A prospective, multicentre study of drug utilisation using the MSBase platform

To prospectively characterise treatment persistence and predictors of treatment discontinuation in an Australian relapsing-remitting multiple sclerosis (RRMS) population. Tertiary MS treatment centres participating in the MSBase registry prospectively assessed treatment utilisation, persistence, predictors of treatment discontinuation and switch rates. Multivariable survival analyses were used to compare treatment persistence between drugs and to identify predictors of treatment discontinuation. 1113 RRMS patients were studied. Patients persisted on their first disease-modifying therapy (DMT) for a median of 2.5 years. Treatment persistence on GA was shorter than on all IFNβ products (p<0.03). Younger age at treatment initiation and higher EDSS were predictive of DMT discontinuation. Patients persisted on subsequent DMTs, for 2.3 years. Patients receiving natalizumab (NAT) as a subsequent DMT persisted longer on treatment than those on IFNβ or GA (p<0.000). The primary reason for treatment discontinuation for any drug class was poor tolerability. Annualised switch or cessation rates were 9.5–12.5% for individual IFNβ products, 11.6% for GA and 4.4% for NAT. This multicentre MS cohort study is the first to directly compare treatment persistence on IFNβ and GA to NAT. We report that treatment persistence in our Australian RRMS population is short, although patients receiving IFNβ as a first DMT persisted longer on treatment than those on GA. Additionally, patients receiving NAT as a subsequent DMT were more likely to persist on treatment than those switched to IFNβ or GA. EDSS and age at DMT initiation were predictive of DMT discontinuation. Treatment intolerance was the principal reason for treatment cessation.

The gendered world of sports reporting in the Australian print media

The mainstream news media have long been charged by feminist and critical media scholars of largely excluding women from its sports coverage, and concomitantly highlighting the ongoing relative absence of female sports reporters. With the 2012 London Olympic Games just past, it is timely to reflect on two areas of sports journalism that recieve sparse scholarly interest from the majority of Australian journalism academics, as technology issues and the future of journalism debates take precedence. The Olympics typically generate more media exposure for female athletes than usual, nevertheless, it remains that there are particular types of 'gender appropriate' events that attract mainstream news media attention during the Games, and other sporting events in general. This paper analyses a month of pre-Olympic sports coverage and general sports coverage in two major Australian newspapers, finding that while pre-Olympic coverage includes more women's sport than in general sport, sportsmen and men's sport remains highly privileged in both areas. The fact that horseracing recieves three times more media coverage than women's sports in this study clearly identifies sportswomen's marginalised status. The paper also maps the number of female sports reporters at these two newspapers, and concludes with some insights into a newsroom culture that typically rejects women as athletes and as sports reporters

Trends in co-authorship in the Australian Group of Eight law reviews

This paper examines trends in co-authorship in the Group of Eight (Go8) law reviews over the period 1975 to 2010. Several conclusions emerge. First, co-authorship occurs less in legal scholarship than in other disciplines. Second, co-authorship in Australian legal scholarship is less than in legal scholarship in the United States. Third, in terms of gender differences, males collaborate more than females. Fourth, academics at the leading law schools provide a disproportionate number of co-authored articles in the Go8 law reviews. Fifth, there is a positive correlation between co-authorship and publishing in the top Australian law journals. Between a quarter and a third of those who co-authored three or more articles in the Go8 law reviews were also those who published the most in the top Australian law journals over the period 1990–2010.