Hypermedia-based Web Services as System Integrators

As we move more closely to the practical concept of the Internet of Things and, our reliance on public and private APIs increases, web services and their related topics have become utterly crucial to the informatics community. However, the question about which style of web services would best solve a particular problem, can raise signi cant and multifarious debates. There can be found two implementation styles that highlight themselves: the RPC-oriented style represented by the SOAP protocol’s implementations and the hypermedia style, which is represented by the REST architectural style’s implementations. As we search examples of already established web services, we can nd a handful of robust and reliable public and private SOAP APIs, nevertheless, it seems that RESTful services are gaining popularity in the enterprise community. For the current generation of developers that work on informatics solutions, REST seems to represent a fundamental and straightforward alternative and even, a more deep-rooted approach than SOAP. But are they comparable? Do both approaches have each speci c best suitable scenarios? Such study is brie y carried out in the present document’s chapters, starting with the respective background study, following an analysis of the hypermedia approach and an instantiation of its architecture, in a particular case study applied in a BPM context.

HEPATOCELLULAR CARCINOMA IN A NON-CIRRHOTIC PATIENT WITH SUSTAINED VIROLOGICAL RESPONSE AFTER HEPATITIS C TREATMENT

Chronic infection by hepatitis C virus (HCV) is one of the main risk factors for the development of liver cirrhosis and hepatocellular carcinoma. However, the emergence of hepatocellular carcinoma (HCC) in non-cirrhotic HCV patients, especially after sustained virological response (SVR) is an unusual event. Recently, it has been suggested that HCV genotype 3 may have a particular oncogenic mechanism, but the factors involved in these cases as well as the profile of these patients are still not fully understood. Thus, we present the case of a non-cirrhotic fifty-year-old male with HCV infection, genotype 3a, who developed HCC two years after treatment with pegylated-interferon and ribavirin, with SVR, in Brazil.