The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action

It is well established that the broad-band muscarinic antagonist, atropine is effective at inhibiting the progression of myopia and does so by preventing the elongation of the vitreous chamber of the eye. However, uncertainty remains as to whether this effect occurs through a receptoral mechanism and, if so, which muscarinic receptor subtype mediates this effect. Previous work, in avian and mammalian models of myopia, implicates the M1 and M4 receptors as potential targets. The current study used physiologically relevant concentrations of highly selective muscarinic antagonists (MT-3 and MT-7) to further characterise the role of the M4 receptor in the control of myopia in the chick model of refractive development.

Embracing off-site innovation in construction in China to enhance a sustainable built environment in urban housing

With the rapid rate of urbanization and pressing need for higher levels of sustainable development within the built environment in China, the housing construction industry presently is facing urgency of shaping a sustainable construction process. This paper examines several sustainability challenges from the large-scale urban housing construction, and explores the connection between off-site innovation and sustainability within a context of China's housing construction industry. The study also identifies four pillars of strategy agendas that could enhance an enabling innovation environment for the ultimate goal of sustainability: (1) institutional environment, (2) public housing market, (3) organisational actions and (4) technological capacity. The knowledge and research findings presented in this paper would provide a ground framework that helps evaluate and assess the significances of off-site innovation to assist with a sustainable built environment.

East Rennell World Heritage Site : misunderstandings, inconsistencies and opportunities in the implementation of the World Heritage Convention in the Pacific Islands

Continuing traditional land tenure and resource use pattern the landscapes and seascapes of the Pacific Islands, and the rights of customary land owners are enshrined in the constitutions of many Pacific Island states. The implications of this for heritage conservation programs implemented by national governments under international Conventions and Agreements are explored through a case study of East Rennell World Heritage site, the first site to be inscribed based on natural criteria under customary ownership and management. Dissatisfaction with World Heritage listing expressed by the community of East Rennell is argued to reflect inconsistencies in the requirements for inscription of the property and a tension between the conservation and ‘beauty pageant’ functions of the World Heritage List.

An un-inherited past: preserving the Khami world heritage site, Zimbabwe

 National narratives are not collective memory. They are socially engineered processes that requires forgetting. The thesis analyses the social dynamics of heritage in postcolonial Africa using Khami World Heritage Site, Zimbabwe. It traces how Khami was uninherited through changing identities, population movement, processes of remembering and forgetting in nation-building processes.

Getting everyone on the same page : A staff focus group study for library web site redesign

Purpose - Using staff focus groups in the redevelopment of a library web site deploys their knowledge of user navigation issues and search strategies and addresses the unique needs of library staff. This paper seeks to describe the process of planning, recruiting, and conducting staff focus groups and provide a discussion of lessons learned. Design/methodology/approach - A committee of professionals and non-professionals from the University of Calgary Library conducted a series of five focus groups with library staff. The goals were to determine their content and service priorities for the redesigned library web site, and also to ensure that staff was included in the redesign process. Findings - This paper makes recommendations for library staff focus group interviewing, including planning, formulating questions, recruitment, conducting sessions, and analysis and reporting. Practical implications - Focus group interviews can be effectively conducted in-house, with careful planning and adherence to established guidelines. Focus groups are a very useful method for gathering staff input for web site redesign or any other library-planning project. Originality/value - This paper will be useful to librarians interested in assessing staff needs and priorities through focus group interviews. The paper fills a void in the library literature regarding the use of library staff as both focus group leaders and participants.

Winter foraging site fidelity of king penguins breeding at the Falkland Islands

Foraging site fidelity has profound consequences for individual fitness, population processes and the effectiveness of species conservation measures. Accordingly, quantifying site fidelity has become increasingly important in animal movement and habitat selection studies. To assess foraging site fidelity in king penguins (Aptenodytes patagonicus) breeding at the Falkland Islands (51.48°S, 57.83°W), we measured overlap in time spent in foraging areas (at a 0.1° × 0.1° grid resolution) between successive foraging trips and foraging route consistency during the crèche period. In total, 30 complete foraging trips from seven king penguins were recorded between April and October 2010. King penguins predominantly foraged on the highly productive Patagonian slope, to the north of the Falkland Islands [median foraging trip distance 213 km (SD = 215 km) and duration 12.8 days (SD = 14.7 days)]. Overlap in time spent in an area on consecutive foraging trips ranged between 2 and 73 % (mean 27 %, SD = 22 %). Bearing during the outbound portion of foraging trips was typically highly repeatable for individual birds, but foraging trip duration and distance were not. Travel during the outbound phase of foraging trips was consistent with the direction of the northward-flowing Falkland Current that may act as a directional cue or facilitate rapid transit to foraging areas. Flexibility in foraging trip distances and durations may be a response to changes in resource availability and changes in the energetic requirements of adults and chicks over an extended breeding cycle.

Effects of site of assessment and variation in wool quality traits on the tactile assessment of textural greasy wool handle

Variation in textural greasy wool handle across the fleece of Merino sheep was explored. Results demonstrate that there were significant differences across nine sites on the fleece. The inclusion of the covariates fibre diameter, fibre diameter co-efficient of variation, staple length, dust penetration, staple structure, greasy wool colour and resistance to compression, helped to explain some of the variation in textural greasy wool handle between sites such that site of assessment was no longer a significant factor (P ≤ 0.065). However, in practice, those involved with clip preparation or sheep selection based on textural greasy wool handle assessment are unlikely to have these measurements available. The results highlight the importance of nominating a site of assessment when recording textural greasy wool handle. © CSIRO 2014.

The social gradient of fractures at any skeletal site in men and women: data from the Geelong Osteoporosis Study Fracture Grid.

Age-specific and age-standardized associations between socioeconomic status (SES) and fractures in adults showed a social gradient of fracture, irrespective of fracture site. Compared to the highest SES, males in the lowest SES group had a sixfold increased odds for any fracture, whilst females had a twofold increased odds.

An investigation into using off-site production in housing construction for the sustainable built environment in China.

Zhai Xiaolin undertook a study of off-site construction in China's housing construction industry during her past four years PhD study. Her research provides an original thinking of embracing offsite construction as a method to help China's construction industry towards a more sustainable built environment. Also her research findings provide possible implications for other developing countries that are also seeking to identify and overcome sustainable crisis in construction industry.

Web-based alcohol intervention for Māori university students: double-blind, multi-site randomized controlled trial

AIMS: Like many indigenous peoples, New Zealand Māori bear a heavy burden of alcohol-related harm relative to their non-indigenous compatriots, and disparities are greatest among young adults. We tested the effectiveness of web-based alcohol screening and brief intervention (e-SBI) for reducing hazardous drinking among Māori university students. DESIGN: Parallel, double-blind, multi-site, randomized controlled trial. SETTING: Seven of New Zealand's eight universities. PARTICIPANTS: In April 2010, we sent e-mail invitations to all 6697 17-24-year-old Māori students to complete a brief web questionnaire including the Alcohol Use Disorders Identification Test (AUDIT)-C, a screening tool for hazardous and harmful drinking. Those screening positive were computer randomized to: <10 minutes of web-based alcohol assessment and personalized feedback (intervention) or screening alone (control). MEASUREMENTS: We conducted a fully automated 5-month follow-up assessment with observers and participants blinded to study hypotheses, design and intervention delivery. Pre-determined primary outcomes were: (i) frequency of drinking, (ii) amount consumed per typical drinking occasion, (iii) overall volume of alcohol consumed and (iv) academic problems. FINDINGS: Of the participants, 1789 were hazardous or harmful drinkers (AUDIT-C ≥ 4) and were randomized: 850 to control, 939 to intervention. Follow-up assessments were completed by 682 controls (80%) and 733 intervention group members (78%). Relative to controls, participants receiving intervention drank less often [RR = 0.89; 95% confidence interval (CI): 0.82-0.97], less per drinking occasion (RR = 0.92; 95% CI: 0.84-1.00), less overall (RR = 0.78; 95% CI: 0.69-0.89) and had fewer academic problems (RR = 0.81; 95% CI: 0.69-0.95). CONCLUSIONS: Web-based screening and brief intervention reduced hazardous and harmful drinking among non-help-seeking Māori students in a large-scale pragmatic trial. The study has wider implications for behavioural intervention in the important but neglected area of indigenous health.