Monitoring the circulation of rotavirus among children after the introduction of the RotarixTM vaccine in Goiânia, Brazil

The epidemiological features of rotavirus A (RVA) infection differ between children from developing and developed countries which could result in differences in vaccine efficacy around the world. To evaluate the impact of RotarixTM on RVA prevalence, we monitored RVA genotypes circulating in Goiânia by monitoring virus in faecal samples from children that had or had not been previously vaccinated. From February-November of 2008, 220 faecal samples were collected from children in seven day-care centres. RVA detection was performed by two methodologies and the results were confirmed by polyacrylamide gel electrophoresis. From the 220 samples, eight were RVA-positive (3.6%) and five were from children that had received either one or two doses of the vaccine. All positive samples were collected from children with diarrhoea during August and September. Genotyping of the RVA characterised five of the viral samples as genotype G2P[4] and one as G8P[4], suggesting that G2P[4] was the predominant circulating genotype in Goiânia during the study. The fact that vaccinated children were also infected by RVA suggests that the vaccine does not fully protect against infection by the G2[P4] RVA genotype.

Catalogue des livres précieux... faisant partie de la bibliothèque de M. Ambroise Firmin-Didot.... Vol. 5 / Introduction par M. Paulin Paris,...

[Collection. Livres. Firmin-Didot, Ambroise. 1878-1884]

Catalogue des livres précieux... faisant partie de la bibliothèque de M. Ambroise Firmin-Didot.... Vol. 3 / Introduction par M. Paulin Paris,...

[Collection. Livres. Firmin-Didot, Ambroise. 1878-1884]

Catalogue des livres précieux... faisant partie de la bibliothèque de M. Ambroise Firmin-Didot.... Vol. 2 / Introduction par M. Paulin Paris,...

[Collection. Livres. Firmin-Didot, Ambroise. 1878-1884]

Catalogue des livres précieux... faisant partie de la bibliothèque de M. Ambroise Firmin-Didot.... Vol. 1 / Introduction par M. Paulin Paris,...

[Collection. Livres. Firmin-Didot, Ambroise. 1878-1884]

Catalogue des livres précieux... faisant partie de la bibliothèque de M. Ambroise Firmin-Didot... / Introduction par M. Paulin Paris,...

[Collection. Livres. Firmin-Didot, Ambroise. 1878-1884]

Reduction in morbidity and mortality from childhood diarrhoeal disease after species A rotavirus vaccine introduction in Latin America : a review

Countries in Latin America were among the first to implement routine vaccination against species A rotavirus (RVA). We evaluate data from Latin America on reductions in gastroenteritis and RVA disease burden following the introduction of RVA vaccine. Published literature was reviewed to identify case-control studies of vaccine effectiveness and population-based studies examining longitudinal trends of diarrhoeal disease reduction after RVA vaccine introduction in Latin American countries. RVA vaccine effectiveness and impact on gastroenteritis mortality and hospitalization rates and RVA hospitalization rates are described. Among middle-income Latin American countries with published data (Mexico, Brazil, El Salvador and Panama), RVA vaccine contributed to a gastroenteritis-associated mortality reduction of 22-41%, a gastroenteritis-associated hospitalization reduction of 17-51% and a RVA hospitalization reduction of 59-81% among children younger than five years of age. In Brazil and El Salvador, case-control studies demonstrated that a full RVA vaccination schedule was 76-85% effective against RVA hospitalization; a lower effectiveness of 46% was seen in Nicaragua, the only low-income country with available data. A growing body of literature offers convincing evidence of "real world" vaccine program successes in Latin American settings, which may be expanded as more countries in the region include RVA vaccine in their immunization programs.

Nouveau programme de sociologie : esquisse d'une introduction générale à l'étude des sciences du monde surorganique / par Eugène de Roberty,...

Collection : Bibliothèque de philosophie contemporaine

Nouveau programme de sociologie : esquisse d'une introduction générale à l'étude des sciences du monde surorganique / par Eugène de Roberty,...

Collection : Bibliothèque de philosophie contemporaine