5-11-19, M. Clemenceau dans le fort de Kirchbach [avec M. Millerand] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56807

Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.

Polymorphisms in IL28B were shown to affect clearance of hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors. We performed a 2-stage GWA study of liver fibrosis progression related to HCV infection. We studied well-characterized HCV-infected patients of European descent who underwent liver biopsies before treatment. We defined various liver fibrosis phenotypes on the basis of METAVIR scores, with and without taking the duration of HCV infection into account. Our GWA analyses were conducted on a filtered primary cohort of 1161 patients using 780,650 single nucleotide polymorphisms (SNPs). We genotyped 96 SNPs with P values <5 × 10(-5) from an independent replication cohort of 962 patients. We then assessed the most interesting replicated SNPs using DNA samples collected from 219 patients who participated in separate GWA studies of HCV clearance. In the combined cohort of 2342 HCV-infected patients, the SNPs rs16851720 (in the total sample) and rs4374383 (in patients who received blood transfusions) were associated with fibrosis progression (P(combined) = 8.9 × 10(-9) and 1.1 × 10(-9), respectively). The SNP rs16851720 is located within RNF7, which encodes an antioxidant that protects against apoptosis. The SNP rs4374383, together with another replicated SNP, rs9380516 (P(combined) = 5.4 × 10(-7)), were linked to the functionally related genes MERTK and TULP1, which encode factors involved in phagocytosis of apoptotic cells by macrophages. Our GWA study identified several susceptibility loci for HCV-induced liver fibrosis; these were linked to genes that regulate apoptosis. Apoptotic control might therefore be involved in liver fibrosis.

Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group.

Epithelioid sarcoma (ES) is rare with a poor prognosis and for which a loss of INI1 expression has been recently reported. We report a study of 106 cases with clinical, histologic, and immunohistochemical data, including INI1 expression, and follow-up data. Of the 106 cases, 70 were the conventional subtype and 36 the large cell subtype. INI1 was negative in 86 cases (81.1%): 57 (81%) of 70 conventional and 29 (81%) of 36 large cell subtypes. Treatment modalities were available for 76 and follow-up for 80 patients. Of the 80 patients, 43 (54%) experienced metastasis and 25 (31%) died of the disease. Univariate analysis indicated that tumor size and mitotic index were significant for metastasis-free survival, whereas proximal location, tumor size, tumor multifocality, and mitotic index were significant for overall survival. Loss of expression of INI1 is frequent in the conventional and large cell subtypes of ES and can be used as a diagnostic marker, but it has no prognostic impact.

28-1-20, Dixmude [voyage présidentiel de M. Raymond Poincaré accompagné de M. Alexandre Millerand et du maréchal Foch] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57795

M. [Alexandre] Millerand [député de la Seine, dans la cour d'honneur du Sénat] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57609

M. Millerand [assis à son bureau] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57928

Vel d'hiv, 28/12/19, départ de la course des 50 kms, [Marcel] Berthet, [Emile] Aerts, [Jean] Alavoine : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57355

[Le] général [Auguste, Edouard] Hirschauer, sénateur de la Moselle [devant l'entrée du Sénat] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57611

M. Millerand : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57712

18/2/20, transmission des pouvoirs, M. Deschanel quitte la Chambre des députés pour se rendre à l'Elysée [avec M. Millerand et l'amiral Grandclément] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58090

M. [Marcel] Donon [sénateur du Loiret, devant l'entrée du Sénat] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57620

[Millerand Alexandre assis à son bureau] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57927