995 resultados para Morton D. (Morton David)


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Mode of access: Internet.

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Includes bibliographical references and index.

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At head of title: Prize essay.

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Mode of access: Internet.

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Mode of access: Internet.

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Loose-leaf.

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Bibliography: v.4, p. [2981]-2998.

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Early history -- In Congress -- The great senatorial contest -- The convention and its nominations -- Speeches -- Sketch of the life of Hon. Hannibal Hamlin -- Letters of acceptance.

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V.1. Eisenhower: June 1952 thru May 1954- V.2. Eisenhower: June 1954 thru December 1955- V.3. Eisenhower: 1956- V.4. Eisenhower: 1957- V.5. Eisenhower: 1958- V.6. Eisenhower: 1959-

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We generated draft genome sequences for two cold-adapted Archaea, Methanogenium frigidum and Methanococcoides burtonii, to identify genotypic characteristics that distinguish them from Archaea with a higher optimal growth temperature (OGT). Comparative genomics revealed trends in amino acid and tRNA composition, and structural features of proteins. Proteins from the cold-adapted Archaea are characterized by a higher content of noncharged polar amino acids, particularly Gin and Thr and a lower content of hydrophobic amino acids, particularly Leu. Sequence data from nine methanogen genomes (OGT 15degrees-98degreesC) were used to generate IIII modeled protein structures. Analysis of the models from the cold-adapted Archaea showed a strong tendency in the solvent-accessible area for more Gin, Thr, and hydrophobic residues and fewer charged residues. A cold shock domain (CSD) protein (CspA homolog) was identified in M. frigidum, two hypothetical proteins with CSD-folds in M. burtonii, and a unique winged helix DNA-binding domain protein in M. burtonii. This suggests that these types of nucleic acid binding proteins have a critical role in cold-adapted Archaea. Structural analysis of tRNA sequences from the Archaea indicated that GC content is the major factor influencing tRNA stability in hyperthermophiles, but not in the psychrophiles, mesophiles or moderate thermophiles. Below an OGT of 60degreesC, the GC content in tRNA was largely unchanged, indicating that any requirement for flexibility of tRNA in psychrophiles is mediated by other means. This is the first time that comparisons have been performed with genome data from Archaea spanning the growth temperature extremes. from psychrophiles to hyperthermophiles