Allan Hancock Pacific expeditions. [Reports]

v.9 (1940-1946)

Allan Hancock Pacific expeditions. [Reports]

v.11 (1945-1958)

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic population. We typed 44 contiguous CD247 single-nucleotide polymorphisms (SNPs) in 8922 SLE patients and 8077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99 × 10(-4) < P < 4.15 × 10(-2)), where we further identified a five-marker haplotype (rs12141731-rs2949655-rs16859085-rs12144621-rs858554; G-G-A-G-A; P(hap) = 2.12 × 10(-5)) that exceeded the most associated single SNP rs858554 (minor allele frequency in controls = 13%; P = 4.99 × 10(-4), odds ratio = 1.32) in significance. Imputation and subsequent association analysis showed evidence of association (P < 0.05) at 27 additional SNPs within intron 1. Cross-ethnic meta-analysis, assuming an additive genetic model adjusted for population proportions, showed five SNPs with significant P-values (1.40 × 10(-3) < P< 3.97 × 10(-2)), with one (rs704848) remaining significant after Bonferroni correction (P(meta) = 2.66 × 10(-2)). Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

Opals from a Mexican mine.

The greatest of the Gods is Quetzalcoati.--The water lady.--The mysterious disappearance of Mrs T. Tompkins Smith.--The vision of Don Juan on the Piedra de los Angeles.--Cosmopolitana mexicana.

Divagaciones literarias.

Libros que les sentado y libros que les de pie.--Recuerdos de Lima.--El fusilado.--Visiones californianas: Ensenada, San Diego, Los Angeles, San Francisco, Los signos.

Illegal aliens. : Hearings, Ninety-second Congress, first session.

"Serial no. 13."

Uniform policy manual for the use of SER Board members, volunteers, staff /

"Third printing."

Hispanics, housing, and HUD : final report for the development of a methodology for involving the Spanish speaking community in HUD programs /

Photocopy.

Medical faculty and students, 1865

Standing in front of the class (from left) are Abram Sager, Alonzo Palmer, Corydon Ford, Moses Gunn, and Silas Douglas (source: Not Just Any Medical School by Horace W. Davenport). On verso: March 1865. Dr. J. Ballard, then at 20 ... Gift of Dr. Elmer Belt, Los Angeles, Calif.

State-of-the-practice retro-reflective measurement devices for pavement markings. Final report.

Federal Highway Administration, Washington, D.C.

Evaluation of retro reflective measurement devices. Final report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Evaluation of retro reflective measurement devices. Summary report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Carranza and his bolshevik regime,

Spanish edition has title: Al margen de la constitución de 1917.

Kindergarten en español : a report /

Cover title.