A produção de sentido em uma narrativa de Fernando Sabino

Este trabalho procura analisar a construção de sentidos na narrativa Ousadia, de Fernando Sabino, tendo como fundamento a adequação entre coerência e coesão realizada pelo autor.

A trajetória de Anísio Teixeira entre 1935 e 1946: uma história contada pela sua correspondência com Monteiro Lobato e Fernando de Azevedo

O intuito do presente texto é destacar na trajetória de Anísio Teixeira ciclos que permitem observar momentos, idéias e fases de sua biografia. Para tanto, vale observar que a idéia de ciclos não se refere apenas a uma forma de delimitação biográfica da vida de Anísio, pois visa colocar em perspectiva o modo de constituição do pensamento e das posições desse educador. Desse modo, a sua correspondência com Fernando de Azevedo e Monteiro Lobato é tomada como produção que atravessa diferentes fases de sua trajetória, permitindo observar o quanto suas posturas e convicções se preservam ou são alteradas ao longo do tempo, em especial durante o período em que esteve afastado da vida publica entre 1936 e 1946.

Fernando de Azevedo: institucionalização da sociologia e modernização brasileira

O artigo desenvolve uma reflexão acerca da contribuição de Fernando Azevedo para a institucionalização da sociologia no Brasil, dando ênfase também a seu papel no processo de modernização ocorrido no país entre as décadas de 1930 e 1960. Nesse sentido, o trabalho procura articular “texto” e “contexto”, como uma opção metodológica, e aponta como hipótese principal que a trajetória institucional e as obras de Azevedo representam um caminho profícuo para se revisar criticamente algumas das explicações canônicas sobre a história das Ciências Sociais no Brasil. Em particular, são destacadas aquelas interpretações que abordaram o tema privilegiando o processo de institucionalização como viés explicativo, inclusive, dando ênfase à década de 1960 como o seu marco inicial. Como resultado do ângulo adotado foi possível chegar a uma versão distinta, ainda que preliminar, dessa história, mostrando que Fernando de Azevedo ocupou um lugar destacado tanto para a institucionalização das Ciências Sociais quanto para o processo de modernização do país.

Fernando de Azevedo: dilemas na institucionalização da sociologia no Brasil

Alessandra Santos Nascimento discute, neste livro, o papel desempenhado por Fernando de Azevedo (1894-1974) na institucionalização da Sociologia no país, refletindo também acerca de atuação do sociólogo, professor e escritor mineiro radicado em São Paulo no processo de modernização do Brasil entre as décadas de 1930 e 1960. A pesquisadora lança a hipótese de que a trajetória institucional e a obra de Fernando Azevedo - que escreveu perto de duas dezenas de livros e centenas de ensaios e artigos, principalmente para o jornal O Estado de São Paulo - demonstram que a história das Ciências Sociais no Brasil demanda uma interpretação diferente da que hoje vigora quase como um cânone: a de que sua institucionalização teria ocorrido a partir da década de 1960. Para a autora, a atuação de Azevedo mostra que tal processo começou bem mais cedo: no fim dos anos 1920 ele já despontara como significativo intérprete da cultura nacional, apaixonado humanista e importante construtor institucional do que aos poucos se tornariam as Ciências Sociais brasileiras.

Peginterferon plus ribavirin and sustained virological response rate in HCV-related advanced fibrosis: a real life study

Background: Tolerance and response to antiviral HCV treatment is poor in advanced fibrosis. The aim of this study was to assess SVR rate and its predictive factors in HCV advanced fibrosis patients treated in real life with full dose PEG-IFN plus RBV and to evaluate the adverse events related to treatment. Methods: A multicentric, retrospective study was conducted at six university hospitals. METAVIR F3 and F4 HCV monoinfected patients who were treated with PEG-IFN and RBV had their data analyzed. A stepwise logistic regression analysis was performed to identify the variables independently related to SVR. Adverse events were recorded during treatment. Results: 308 patients were included, 75% genotype 1 and 23% genotype 3. METAVIR F3 was present in 39% and F4 in 61% of patients. The median Child Pugh score for F4 patients was 5 (5–9). The global SVR rate was 34%, 11% were relapsers and 55% were nonresponders. SVR rates were similar between patients treated with PEG-IFN alfa 2a or alfa 2b (p = 0.24). SVR rates according to Child–Pugh score were 26% (Child A) and 18% (Child B). The independent factors related to SVR in F4 patients were genotype 3, RVR and fewer Child Pugh score points. Treatment interruption occurred in 31% patients and death occurred in 1.9%, all with liver cirrhosis. Conclusion: Treatment of HCV in patients with advanced fibrosis should not be postponed. However, a very careful evaluation of cirrhotic patients must be performed before treatment is indicated and careful monitoring is required during treatment.

Activity of some isoenzymatic systems in stored coffee grains

Considering the worldwide consumption of coffee, it is natural that throughout the history many people have dedicated the research to markers that contribute somehow on gauging its quality. This research aimed to evaluate the biochemical performance of arabica coffee during storage. Coffee in beans (natural) and in parchment (pulped) dried in concrete terrace and in dryer with heated air were packed in jute bags and stored in not controlled environmental conditions. Enzymatic activities of superoxide dismutase, catalase, peroxidase, polyphenoloxidase, esterase and lipoxygenase in coffee grains were evaluated at zero, three, six, nine and twelve months by means of electrophoresis. Independently of the drying method, the activity of isoenzymatic complexes highlighted deteriorative processes in stored grains of coffee. The treatments 60/40º C and 60º C used to reduce the water content imposed a greater stress condition, accelerated metabolism of natural coffee in the storage with decreased activity of defense mechanisms due to latent damage in these grains. Natural coffees are more sensible to high drying temperatures and its quality reduces faster than pulped coffee in the storage.

As construções de identidades nacionais: as óticas poéticas de Agostinho Neto e Fernando Pessoa

Pós-graduação em Letras - FCLAS

Bacterial Pathogens Related to Chronic Suppurative Otitis Media in Individuals With Cleft Palate: Bacteriological Culture and Polymerase Chain Reaction

Objective: To characterize the microbial etiology of chronic suppurative otitis media comparing the methods of classical bacteriological culture and polymerase chain reaction.Design/Setting/Patients: Bacteriological analysis by classical culture and by molecular polymerase chain reaction of 35 effusion otitis samples from patients with cleft lip and palate attending the Hospital for Rehabilitation of Craniofacial Anomalies of the University of Sao Paulo, Bauru, Brazil.Interventions: Collection of clinical samples of otitis by effusion through the external auditory tube.Main Outcome Measure: Otolaryngologic diagnosis of chronic suppurative otitis media.Results: Positive cultures were obtained from 83% of patients. Among the 31 bacterial lineages the following were isolated. In order of decreasing frequency: Pseudomonas aeruginosa (54.9%), Staphylococcus aureus (25.9%), and Enterococcus faecalis (19.2%). No anaerobes were isolated by culture. The polymerase chain reaction was positive for one or more bacteria investigated in 97.1% of samples. Anaerobe lineages were detected by the polymerase chain reaction method, such as Fusobacterium nucleatum, Bacteroides fragilis, and Peptostreptococcus anaerobius.Conclusions: Patients with cleft lip and palate with chronic suppurative otitis media presented high frequency of bacterial infection in the middle ear. The classical bacteriological culture did not detect strict anaerobes, whose presence was identified by the polymerase chain reaction method.

A new experimental model of cigarette smoke-induced emphysema in Wistar rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Identification of species of the Euterpe genus by rare earth elements using inductively coupled plasma mass spectrometry and linear discriminant analysis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Isolation and Identification of Environmental Mycobacteria in the Waters of a Hemodialysis Center

The use of poorly treated water during hemodialysis may lead to contamination with nontuberculous mycobacteria (NTM). This study aimed to isolate and identify NTM species in the water of a Brazilian hemodialysis center. We collected 210 samples of water from the hydric system of the unit (post-osmosis system, hemodialysis rooms, reuse system, and hemodialysis equipment) and from the municipal supply network; we isolated the NTM by a classic microbiological technique and identified them by the PCR restriction enzyme pattern of the hsp65 gene (PRA). Fifty-one (24.3 %) of the collected samples tested positive for NTM; both the municipal supply network (2 samples, 3.2 %) and the hydric system of the hemodialysis center (49 samples, 96.1 %) contained NTM. We isolated and identified potentially pathogenic bacteria such as Mycobacterium lentiflavum (59.0 %) and M. kansasii (5.0 %), as well as rarely pathogenic bacteria like M. gordonae (24.0 %), M. gastri (8.0 %), and M. szulgai (4.0 %). The ability of NTM to cause diseases is well documented in the literature. Therefore, the identification of NTM in the water of a Brazilian hemodialysis center calls for more effective water disinfection procedures in this unit.

Evaluation of clinical safety and anthelmintic efficacy of aurixazole administed orally at 24 mg/kg in cattle

The current study evaluated, in vivo, the clinical safety and the anthelmintic efficacy of 24% aurixazole (24 mg/kg), administered orally, in bovines. Two experiments were conducted: the first one evaluating the clinical safety of 24% aurixazole (24 mg/kg) in cattle, and a second one evaluating the anthelmintic efficacy of aurixazole (24 mg/kg) against gastrointestinal nematodes on naturally infected cattle. Based on the results of clinical safety, no alterations on clinical and haematological signs and on the biochemical values obtained in animals treated orally with aurixazole 24 mg/kg were observed. Regarding the results of reduction or efficacy, obtained by eggs per gram of faeces (EPG) counts, the formulation of aurixazole reached values superior to 99% (arithmetic means) in all post-treatment dates. In two occasions, this formulation reached maximum efficacy (100%). Comparing these results with the reduction percentages obtained by EPG counts, it is possible to verify that the values obtained by all three formulations were compatible with the efficacy results. Aurixazole reached maximum efficacy (100%) against Haemonchus placei, Cooperia spatulata and Oesophagostomum radiatum. Against Cooperia punctata, this formulation reached an efficacy index of 99.99%. Regarding aurixazole, no specific trials were conducted on the field in order to evaluate the behaviour of this molecule against helminths that are resistant to other molecules, specially isolated levamisole and disophenolat: Due to this fact, future studies will be necessary to assess the effectiveness of aurixazole against strains of nematodes that are resistant to levamisole and disophenolat, but the results of clinical safety and efficacy described in this study allow us to conclude that the aurixazole molecule, concomitantly with other measures and orally administered formulations, can be another important tool in the control of nematodes parasitizing bovines. (C) 2014 Published by Elsevier Ltd.

Entre “sobrados, lojas e funcos”: memória, identidade e representação literária na trilogia romanesca de Henrique Teixeira de Sousa

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Comparação de suínos convencionais e SPF (specific pathogen free)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)