The recent decline in mortality from Hodgkin lymphomas in central and eastern Europe

BACKGROUND: Hodgkin lymphoma (HL) is a largely curable disease and its mortality had steadily declined in western Europe since the late 1960s. Only modest declines were, however, observed in central/eastern Europe. MATERIALS AND METHODS: We updated trends in mortality from HL in various European areas up to 2004 and analyzed patterns in incidence for selected European countries providing national data. RESULTS: In most western European countries, HL mortality continued to steadily decline up to the mid 2000s. More recent reductions were also observed in eastern European countries. Overall, mortality from HL declined from 1.17/100,000 (age-standardized, world population) in 1980-1989 to 1.42/100,000 in 2000-2004 in men from the 15 member states of the European Union (EU) from western and northern Europe. In the EU 10 accession countries of central and eastern Europe, male mortality from HL was 1.42/100,000 in 1980-1984, 1.32 in 1990-1994, and declined to 0.76 in 2000-2004. Similar trends were observed in women. No consistent patterns were found for HL incidence. CONCLUSIONS: The present work confirms the persistent declines in HL mortality in western European countries, and shows favorable patterns over more recent calendar years in central/eastern ones, where rates, however, are still at levels observed in western Europe in the early 1990s.

A microarray-based system for the simultaneous analysis of single nucleotide polymorphisms in human genes involved in the metabolism of anti-malarial drugs

Background: In order to provide a cost-effective tool to analyse pharmacogenetic markers in malaria treatment, DNA microarray technology was compared with sequencing of polymerase chain reaction (PCR) fragments to detect single nucleotide polymorphisms (SNPs) in a larger number of samples. Methods: The microarray was developed to affordably generate SNP data of genes encoding the human cytochrome P450 enzyme family (CYP) and N-acetyltransferase-2 (NAT2) involved in antimalarial drug metabolisms and with known polymorphisms, i.e. CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, and NAT2. Results: For some SNPs, i.e. CYP2A6*2, CYP2B6*5, CYP2C8*3, CYP2C9*3/*5, CYP2C19*3, CYP2D6*4 and NAT2*6/*7/*14, agreement between both techniques ranged from substantial to almost perfect (kappa index between 0.61 and 1.00), whilst for other SNPs a large variability from slight to substantial agreement (kappa index between 0.39 and 1.00) was found, e. g. CYP2D6*17 (2850C>T), CYP3A4*1B and CYP3A5*3. Conclusion: The major limit of the microarray technology for this purpose was lack of robustness and with a large number of missing data or with incorrect specificity.

Recargos e intereses en la nueva Ley General Tributaria

El presente comentario tiene por objeto ofrecer un esquema general a través del cual se muestre el juego de recargos, intereses y sanciones que se derivan del incumplimiento de las obligaciones formales y/o materiales del tributo, atendiendo al período de tiempo en el que se produzcan.

Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.

Novel alpha-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group=4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.

Listautumattomanyrityksen arvonmääritys sukupolvenvaihdoksessa

Tutkimuksen tarkoituksena on selvittää listautumattoman osakeyhtiön sukupolvenvaihdoksessa esiintyviä vero-oikeudellista säätelyä ja arvonmääritystä, kun sukupolvenvaihdos toteutetaan mahdollisimman alhaisella osakkeen arvolla. Osakkeen arvonmäärittäminen liian alhaiselle tasolle saattaa johtaa lahjaverotukseen. Tutkimuksessa havaittiin, että case yrityksen tapauksessa, verohallinnon mukaisella arvonmäärityksellä ohjeistuksella ja Lee & Swathanin modifioidulla EVA -mallilla saadaan alhaisimmat käyvät arvot sukupolvenvaihdoksen suorittamiseksi. Tutkimus pohjautuu arvonmäärityksen osalta ulkomaalaiseen sekä kotimaiseen taloustieteelliseen kirjallisuuteen ja artikkeleihin. Vero-oikeudellinen säätely pohjautuu suomalaiseen oikeustieteelliseen kirjallisuuteen, artikkeleihin ja verohallinnon asiantuntijoiden haastatteluja. Tutkimuksessa on aineistona käytetty case-yrityksen ja sen toimialan tilinpäätöstietoja. Tässä tutkimuksessa onkäytetty konstruktiivista tutkimusmetodologiaa.

Optimització i implementació del Repositori Obert de la Universitat de Lleida

Fer un estudi d'usabilitat del Repositori Obert de la UdL. El repositori recull, gestiona, difon i preserva les publicacions en format digital i en accés obert derivades de l'activitat acadèmica i investigadora, les publicacions institucionals i altres materials de la comunitat universitària.

Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie

Scrapie is a transmissible spongiform encephalopathy with a wide PrPres dissemination in many non-neural tissues and with high levels of transmissibility within susceptible populations. Mechanisms of transmission are incompletely understood. It is generally assumed that it is horizontally transmitted by direct contact between animals or indirectly through the environment, where scrapie can remain infectious for years. In contrast, in utero vertical transmission has never been demonstrated and has rarely been studied. Recently, the use of the protein misfolding cyclic amplification technique (PMCA) has allowed prion detection in various tissues and excretions in which PrPres levels have been undetectable by traditional assays. The main goal of this study was to detect PrPres in fetal tissues and the amniotic fluid from natural scrapie infected ewes using the PMCA technique. Six fetuses from three infected pregnant ewes in an advanced clinical stage of the disease were included in the study. From each fetus, amniotic fluid, brain, spleen, ileo-cecal valve and retropharyngeal lymph node samples were collected and analyzed using Western blotting and PMCA. Although all samples were negative using Western blotting, PrPres was detected after in vitro amplification. Our results represent the first time the biochemical detection of prions in fetal tissues, suggesting that the in utero transmission of scrapie in natural infected sheep might be possible.

Correlated genetic effects on reproduction define a domestication syndrome in a forest tree.

Compared to natural selection, domestication implies a dramatic change in traits linked to fitness. A number of traits conferring fitness in the wild might be detrimental under domestication, and domesticated species typically differ from their ancestors in a set of traits known as the domestication syndrome. Specifically, trade-offs between growth and reproduction are well established across the tree of life. According to allocation theory, selection for growth rate is expected to indirectly alter life-history reproductive traits, diverting resources from reproduction to growth. Here we tested this hypothesis by examining the genetic change and correlated responses of reproductive traits as a result of selection for timber yield in the tree Pinus pinaster. Phenotypic selection was carried out in a natural population, and progenies from selected trees were compared with those of control trees in a common garden experiment. According to expectations, we detected a genetic change in important life-history traits due to selection. Specifically, threshold sizes for reproduction were much higher and reproductive investment relative to size significantly lower in the selected progenies just after a single artificial selection event. Our study helps to define the domestication syndrome in exploited forest trees and shows that changes affecting developmental pathways are relevant in domestication processes of long-lived plants.

La descoberta del Jo. Programa individualitzat per a la incorporació social PINS

L’autoconsciència, la motivació, la empatia, el control emocional i les habilitats socials són cinc de les eines que configuren l’autoconeixement, sent aquest últim l’instrument bàsic per enfrontar-se al repte que suposa viure, des dels paràmetres de la Intel·ligències Emocional. De fet, l’autoconeixement és la clau del comportament per tal d’arribar a l’èxit. Èxit entès com a benestar i qualitat de vida. La importància que ha tingut incidir en aquest col·lectiu amb aquest tipus de praxis recau sobre els recorreguts vitals que les persones amb problemes de drogodependències han viscut, i sobretot, la manera en què els han viscut. Per aquest motiu, aquest projecte és un recurs concret que ha donat resposta a algunes de les necessitats detectades i ha proposat una línia de treball pedagògicament innovadora centrada en la persona; mantenint l’esperit de la flexibilitat i concreció a través del treball personal i grupal. Amb aquest projecte s’ha mostrat la importància del camp de l’educació emocional per a persones amb algun tipus de drogodependència, essent la primera part d’un programa per a la incorporació social que aborda una nova dimensió de treball en les Comunitats Terapèutiques.

Número de anteras por flor, grãos de pólen por antera e capacidade germinativa do pólen de diferentes cultivares de macieiras

O objetivo deste trabalho foi avaliar o número de anteras por flor, grãos de pólen por antera e capacidade germinativa do pólen de diferentes cultivares de macieiras. O trabalho foi executado no Laboratório de Fisiologia do Desenvolvimento e Genética Vegetal da Universidade Federal de Santa Catarina, e as coletas a campo foram realizadas na Epagri/Estação Experimental de Caçador-SC, em outubro de 2005. Foram utilizadas as seguintes cultivares comerciais de macieira desenvolvidas no Brasil: Primícia, Princesa, Fred Hough, Catarina, Baronesa, Lisgala, Suprema, Condessa, Daiane, Duquesa, Imperatriz e Joaquina. As cultivares de macieira Condessa, Princesa, Eva, Duquesa, Imperatriz, Gala, Fred Hough, Daiane, Baronesa e Suprema produzem pólen em quantidade suficiente e com boa capacidade germinativa. A cv. Condessa, embora apresente alta capacidade germinativa de pólen, produz menos anteras e grãos de pólen por antera que as demais. A cv. Princesa é a que apresenta o melhor perfil como polinizadora, por conjugar número de anteras/flor, número de grãos de pólen/antera e capacidade germinativa do pólen mais satisfatórios.

Jornada de Camp de l'Arròs 2014

La jornada de referència de l’arròs organitzada per l’IRTA ofereix una oportunitat clau a tot el sector arrosser de conèixer el darrers avenços tecnològics, a l’hora que és un punt de trobada per a tècnics, agricultors i professionals vinculats al món de l’arròs. Temàtiques tant diverses com: nous fertilitzants, noves varietats d’arròs, nous pesticides i estratègies de lluita contra malalties fan que aquesta jornada sigui d’interès per a un ampli sector agrari.

La percepción de los estudiantes universitarios de Bellas Artes sobre sus dificultades de aprendizaje: el caso de las competencias de búsqueda y selección de información relevante

[spa]Identificar las dificultades halladas en el proceso de aprendizaje con la especial relación entre el esfuerzo y el logro experimentada por los estudiantes implica afrontar uno de los problemas fundamentales del aprendizaje. El presente artículo pretende abordar los aprendizajes vinculados a las competencias transversales de la búsqueda y selección de información desde el examen de la percepción de los estudiantes universitarios de arte en la realización de una carpeta de aprendizaje adaptada a la titulación y al perfil del estudiante. A partir de un enfoque cuantitativo, y mediante un estudio descriptivo transversal, se analizará la relación existente entre el esfuerzo realizado, los resultados de aprendizaje declarados y la relación entre ambas cuestiones -lo que a la postre define las dificultades- que manifiestan los estudiantes. [eng]This article aims to address the learning skills associated with the competence of searching and selecting information from the examination of the perceptions of art college students in the drawing up of a learning portfolio tailored to the degree and student profile. From a quantitative approach, and through a cross-sectional descriptive study, we will analyze the relationship between effort, stated learning outcomes and the relationship between these two issues what ultimately defines the difficulties which declare the students.