Magnetophoretic circuits for digital control of single particles and cells.

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.

A LabVIEW Platform for Preclinical Imaging Using Digital Subtraction Angiography and Micro-CT.

CT and digital subtraction angiography (DSA) are ubiquitous in the clinic. Their preclinical equivalents are valuable imaging methods for studying disease models and treatment. We have developed a dual source/detector X-ray imaging system that we have used for both micro-CT and DSA studies in rodents. The control of such a complex imaging system requires substantial software development for which we use the graphical language LabVIEW (National Instruments, Austin, TX, USA). This paper focuses on a LabVIEW platform that we have developed to enable anatomical and functional imaging with micro-CT and DSA. Our LabVIEW applications integrate and control all the elements of our system including a dual source/detector X-ray system, a mechanical ventilator, a physiological monitor, and a power microinjector for the vascular delivery of X-ray contrast agents. Various applications allow cardiac- and respiratory-gated acquisitions for both DSA and micro-CT studies. Our results illustrate the application of DSA for cardiopulmonary studies and vascular imaging of the liver and coronary arteries. We also show how DSA can be used for functional imaging of the kidney. Finally, the power of 4D micro-CT imaging using both prospective and retrospective gating is shown for cardiac imaging.

Developing Quantitative Methodologies for the Digital Humanities: A Case Study of 20th Century American Commentary on Russian Literature

Using scientific methods in the humanities is at the forefront of objective literary analysis. However, processing big data is particularly complex when the subject matter is qualitative rather than numerical. Large volumes of text require specialized tools to produce quantifiable data from ideas and sentiments. Our team researched the extent to which tools such as Weka and MALLET can test hypotheses about qualitative information. We examined the claim that literary commentary exists within political environments and used US periodical articles concerning Russian literature in the early twentieth century as a case study. These tools generated useful quantitative data that allowed us to run stepwise binary logistic regressions. These statistical tests allowed for time series experiments using sea change and emergency models of history, as well as classification experiments with regard to author characteristics, social issues, and sentiment expressed. Both types of experiments supported our claim with varying degrees, but more importantly served as a definitive demonstration that digitally enhanced quantitative forms of analysis can apply to qualitative data. Our findings set the foundation for further experiments in the emerging field of digital humanities.

Uso de tecnología digital en la comprensión de parámetros en funciones polinomiales

Los estudiantes de enseñanza media se enfrentan al uso e interpretación de los parámetros en funciones polinomiales, lugares geométricos y expresiones algebraicas en general. Este hecho conduce a la necesidad no sólo de diferenciar los parámetros de otro tipo de literales como variables o incógnitas, sino también dar un sentido de uso a los mismos con la finalidad de agrupar los objetos matemáticos en entidades más generales como son las familias de funciones. El presente taller tiene como objetivo mostrar la influencia que puede tener el uso de un recurso tecnológico dinámico en la comprensión de esta polisemia de las literales, así como en la optimización de la ideas como puede ser la generalización.

Espaço de aprendizagem digital: o aprender a aprender por coperaçâo

O estudo é uma pesquisa-ação, na área da Informática na Educação Matemática, sobre a forma de aprender a aprender cooperativamente, segundo os Estudos Sociológicos de Piaget, no espaço de aprendizagem digital da Matemática, desenvolvida no IFRS – Osório, em 2011 e 2012, com 60 estudantes do ensino médio técnico em informática. A questão central é como analisar e compreender o processo de aprendizagem cooperativa dos conceitos de Matemática neste espaço. A definição deste espaço e de aprendizagem cooperativa é resultado desta pesquisa. Além disso, demonstra-se a construção dos conceitos de Matemática, e a mobilização dos estudantes em aprender incorporando-se as tecnologias digitais online às aulas de Matemática, sob a autonomia e responsabilidade de cada estudante e/ou de seu grupo.

Tecnología digital, actos y procesos semióticos en el estudio del objeto continuidad

La teoría de instrucción matemática significativa basada en el modelo ontológico -semiótico de la cognición matemática denominado Teoría de las Funciones Semióticas (TFS ) proporciona un marco unificado para el estudio de las diversas formas de conocimiento matemático y sus respectivas interacciones en el seno de los sistemas didácticos (Godino, 1998 ). Presentamos un desarrollo de esta teoría consistente en la descomposición de un objeto, para nuestro modelo, la Continuidad, en unidades para identificar entidades y las funciones semióticas que se establecen, en el proceso de enseñanza y aprendizaje en una institución escolar, implementando un ambiente de tecnología digital (calculadora graficadora TI-92 Plus y/o Voyage 200).

Geometrías no euclídeas: un acercamiento con tecnología digital

En este curso corto utilizamos distintas aplicaciones de geometría dinámica para realizar construcciones geométricas en el modelo de Poincaré para geometría hiperbólica con el propósito de investigar y determinar la naturaleza de algunos teoremas de geometría para la enseñanza secundaria y superior. De esta forma clasificamos algunos de los teoremas de geometría plana como neutrales, estrictamente euclidianas o estrictamente hiperbólicos.

Distributed digital post-production

It is now possible to use powerful general purpose computer architectures to support post-production of both video and multimedia projects. By devising a suitable portable software architecture and using high-speed networking in an appropriate manner, a system has been constructed where editors are no longer tied to a specific location. New types of production, such as multi-threaded interactive video, are supported. Editors may also work remotely where very high speed network connection is not currently provided. An object-oriented database is used for the comprehensive cataloging of material and to support automatic audio/video object migration and replication. Copyright © 1997 by the Society of Motion Picture and Television Engineers, Inc.

Multiphysics modelling for electronics design

The future of many companies will depend to a large extent on their ability to initiate techniques that bring schedules, performance, tests, support, production, life-cycle-costs, reliability prediction and quality control into the earliest stages of the product creation process. Important questions for an engineer who is responsible for the quality of electronic parts such as printed circuit boards (PCBs) during design, production, assembly and after-sales support are: What is the impact of temperature? What is the impact of this temperature on the stress produced in the components? What is the electromagnetic compatibility (EMC) associated with such a design? At present, thermal, stress and EMC calculations are undertaken using different software tools that each require model build and meshing. This leads to a large investment in time, and hence cost, to undertake each of these simulations. This paper discusses the progression towards a fully integrated software environment, based on a common data model and user interface, having the capability to predict temperature, stress and EMC fields in a coupled manner. Such a modelling environment used early within the design stage of an electronic product will provide engineers with fast solutions to questions regarding thermal, stress and EMC issues. The paper concentrates on recent developments in creating such an integrated modeling environment with preliminary results from the analyses conducted. Further research into the thermal and stress related aspects of the paper is being conducted under a nationally funded project, while their application in reliability prediction will be addressed in a new European project called PROFIT.

An integrated approach to flow, thermal and mechanical modeling of electronics devices

The future success of many electronics companies will depend to a large extent on their ability to initiate techniques that bring schedules, performance, tests, support, production, life-cycle-costs, reliability prediction and quality control into the earliest stages of the product creation process. Earlier papers have discussed the benefits of an integrated analysis environment for system-level thermal, stress and EMC prediction. This paper focuses on developments made to the stress analysis module and presents results obtained for an SMT resistor. Lifetime predictions are made using the Coffin-Manson equation. Comparison with the creep strain energy based models of Darveaux (1997) shows the shear strain based method to underestimate the solder joint life. Conclusions are also made about the capabilities of both approaches to predict the qualitative and quantitative impact of design changes.

Digital Forestry: A white paper

Digital Forestry has been proposed as “the science, technology, and art of systematically acquiring, integrating, analyzing, and applying digital information to support sustainable forests.” Although rooted in traditional forestry disciplines, Digital Forestry draws from a host of other fields that, in the past few decades, have become important for implementing the concept of forest ecosystem management and the principle of sustainable forestry. Digital Forestry is a framework that links all facets of forestry information at local, national, and global levels through an organized digital network. It is anticipated that a new set of principles will be established when practicing Digital Forestry concept for the evolution of forestry education, research, and practices as the 21st century unfolds.