Crise da cafeicultura e seus efeitos socioeconômicos no município de Dracena (SP)

The coffee crisis in the 1980s reached deeply municipality of Dracena, considering that the coffee had significant social and economic importance to the area. In this context, the research aimed to analyze the socioeconomic consequences that this crisis has provided small rural proprietors of the county. To achieve this goal we seek to articulate the theoretical reference, with data from secondary sources, interviews with the main responsible for the agricultural sector and an application questionnaire to 21 small rural proprietors of the county. It was found that, due to the dependence relationship with the coffee, the economy of the city suffered from the attack of said culture during the 1980s. Rural producers who cultivated such crops as the main, had to readjust productively to remain in the countryside, but the economic and social development that coffee was brought in earlier times was not rescued. As a consequence, there has been an intensification of evasion demographic of rural municipality, a process that had begun in the 1970s and was strongly reinforced by the crisis of the coffee culture. We note that from the 2000s, the situation became better for small rural proprietors in order that public policies implemented now serve, in part, the needs of those with greater efficiency. This situation can be evidenced by a slight reduction in the number of rural people dracenense. Despite improvements recorded since the 2000s, the situation is still not ideal, given that many small proprietors surveyed expressed dissatisfaction. In this context, we note that the performance and joint of federal, state and municipal government are essential so that public policies are efficient, thus providing decent conditions for social reproduction of small rural proprietors and their dependents in the countryside

Aplicação dos conceitos da ecologia de paisagem para a definição de hotspots de conservação e de conectividade entre o Complexo Cantareira e Nazaré Paulista

The Atlantic Forest biome, reduced to 12% of its original coverage, holds a significant portion of brazilian biodiversity, with high levels of endemism. Among the few remaining areas of the Atlantic, there is the region between the Complex of Cantareira and the municipality of Nazaré Paulista, which will be the object of study of this work. Using the concepts of Landscape Ecology, and analysis of thematic maps, this study aims to characterize the region in a ecologically scaled perspective, identifying two types of hotspots: i) for conservation and ii) for maintain habitat connectivity. Concepts of Landscape Ecology as landscape structure, patches, matrix, corridors (structural and functional) and connectivity, as well as their effects on local biodiversity was adopted and applied in the study region. We also analyzed the effects of roads, hydrographic system, Permanent Protection Areas (PPAs), and Conservation Units for flora and fauna maintenance at regional scale. This allowed us to define strategies and priority areas for the conservation and restoration of forest fragments of Atlantic Forest remnants within the study region. This study generated relevant knowledge for a better planning the region in order to create best conditions for the maintenance of regional biodiversity, and consequently, allowing to improve the quality of life for local population

Planejamento, síntese e avaliação da capacidade de doação de óxido nítrico de novos derivados antiinflamatóios

A formação do trombo arterial, composto predominantemente por plaquetas, se dá sob condições de estresse de cisalhamento elevado, nos locais de lesão aterosclerótica vascular e fluxo sanguíneo perturbado e tem como consequência diminuição ou obstrução do calibre dos vasos dos diferentes órgãos podendo levar a eventos isquêmicos. As doenças cardiovasculares são consideradas as principais causas de morte no mundo. Nesse contexto, estima-se que a aterosclerose/aterotrombose seja a causa primária de doença arterial coronariana e acidente vascular cerebral representado mais de 50% das causas de mortes em países ocidentais . É sabido que a aterosclerose, primeiro evento que predispõe à aterotrombose, é considerada um processo inflamatório crônico, e que a utilização de antiinflamatórios não esteroidais (AINEs) COX-1, melhor estabilizam a estrutura da placa ateromatosa impedindo o rompimento e a consequente formação do trombo. Neste contexto, no presente trabalho foram obtidos de novos candidatos a fármacos com propriedades doadoras de NO e antiagregantes plaquetárias, através da estratégia de hibridação molecular dos AINEs contendo uma subunidade doadora de óxido nítrico, representada pelos furoxanos, e espaçada por uma subunidade N-acil hidrazônica. Dessa forma, a inibição da síntese de tromboxanos associada à doação de óxido nítrico permitiu atuação nas plaquetas através de um mecanismo múltiplo de ação com fins de diminuição da agregação plaquetária. Os produtos intermediários e finais apresentaram bons rendimentos e foram caracterizados por técnicas analíticas as quais predisseram que as estruturas propostas foram obtidas. Todos os compostos se como doadores de óxido nítrico. Os compostos 1a e 3a apresentaram atividade analgésica superior a dipirona, utilizada como controle. No ensaio de agregação plaquetária ―in vitro‖... (Resumo completo, clicar acesso eletrônico abaixo)

Avaliação das taxas de erosão química e física na bacia hidrográfica do Ribeirão Jacutinga (SP)

Currently with the growing technological advancement and global, new areas are being devastated, and as a result, the erosion became more frequent causing loss of soil, infiltration capacity of the surface and weathering of rocks. In this way, environmental studies are increasingly frequent to understand the environment in which we live, but also to avoid any degradation of the same and of finite natural resources, which are essential for human life. From this, this work has as main goal, analyzing the rates of chemical and mechanical erosive watershed of Ribeirão Jacutinga, at its mouth, in the city of Rio Claro, supporting environmental studies and sustainable development today. Order to reach these values were measured and total dissolved solids in suspension in the stream during the months from January to July 2012. As results included higher rates of both physical and chemical weathering in the rainy months, especially january

Avaliação dos efeitos do piretróide permetrina nas glândulas salivares de fêmeas de carrapatos Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae)

Devido à grande importância médico-veterinária dos carrapatos e a ampla utilização de produtos químicos sintéticos para o seu controle, tais como a permetrina, o presente estudo trouxe uma análise morfofisiológica, citoquímica e da reorganização do citoesqueleto durante os processos de degeneração e de morte celular que ocorreram nas glândulas salivares de fêmeas semi-ingurgitadas de carrapatos Rhipicephalus sanguineus quando expostas a 206, 1031 e 2062 ppm de permetrina. Os resultados obtidos mostraram que a permetrina é um potente agente químico que interfere na morfofisiologia do tecido glandular desta espécie, causando severas alterações na forma dos ácinos, bem como intensa vacuolização citoplasmática nas células acinares e acentuada desorganização do tecido glandular, culminando num avançado processo de degeneração, com consequente formação de corpos apoptóticos. Além disso, este piretróide comprometeu a capacidade de secreção das glândulas salivares, visto a drástica redução de proteínas, lipídeos e polissacarídeos nas diferentes células acinares. O material genético do tecido glandular também mostrou severas alterações induzidas pela permetrina, tais como: na forma e no tamanho do núcleo das células acinares, marginalização da cromatina, fragmentação nuclear, bem como surgimento de núcleos picnóticos, principalmente quando aplicadas as maiores concentrações do produto. Com relação à reorganização do citoesqueleto, os resultados revelaram que a permetrina foi capaz de modificar o citoesqueleto das glândulas salivares de R. sanguineus por meio de um processo gradual de desintegração à medida que as concentrações do acaricida aumentaram. Nestas células glandulares, os processos de morte celular ocorreram num ritmo mais acelerado do que em condições naturais, nas quais esse processo dar-se-ia somente no final do ingurgitamento da fêmea. Como consequência da...

Avaliação da segurança das prescrições médicas de usuários de insulina: estudo piloto

A prescrição médica de insulina e outros medicamentos pode apresentar comprometimento de sua segurança, diante de problemas envolvendo ilegibilidade e ausência de informações. Como consequência instala-se falhas na comunicação e no entendimento do conteúdo prescrito, o que pode ocasionar um erro de medicação com prejuízo terapêutico. Diante disto, o presente trabalho, parte integrante da pesquisa de doutorado “Desenvolvimento e avaliação de um protocolo de atenção farmacêutica intensiva com metodologia educacional de empoderamento para adultos com Diabetes Mellitus tipo 2 – estudo translacional fase 1”, desenvolvido por Drª . Silvia F. L. Cavalheiro, sob orientação da Profª . Drª . Chung Man Chin, teve como objetivo avaliar a segurança das prescrições médicas contendo insulina através da Triagem Técnica das Prescrições Médicas (TTPM), com o intuito de checar eventuais problemas que pudessem afetar a eficácia terapêutica. Metodologia: foi realizado um estudo transversal retrospectivo de 16 prescrições médicas, de 9 adultos com DM2 usuários de insulina. A TTPM foi realizada através da utilização do instrumento específico, elaborado para este fim, onde foram checados eventuais problemas que poderiam afetar a segurança da prescrição de insulina. Resultados e Discussões: foi observado que todas as receitas médicas apresentavam algum problema que pudesse afetar a segurança da prescrição. Dentre os problemas mais observados a falta de informações sobre o paciente (idade e/ou endereço) e o uso de abreviaturas foi encontrada em todas as prescrições. A omissão de dados sobre o prescritor, ou local onde trabalha, como endereço e/ou telefone foi encontrada em 94% das prescrições. Além do mais, 74% das prescrições foram consideradas ilegíveis ou pouco legíveis. Conclusão: os problemas observados envolvem a prescrição inadequada... (Resumo completo, clicar acesso eletrônico abaixo)

Geologia das coquinas-reservatório do Campo de Pampo, Bacia de Campos

The Pampo oil field is located in the southwest of the trend Badejo-Linguado-Pampo in an accumulation of single - mixed trap: structural-stratigraphic-diagenetic. Its main reservoir is a coquina shell of bivalves (the lowest) in the Lagoa Feia Group. During the rift phase, the Badejo-Linguado-Pampo trend´s accumulations evolve according to three tectono-stratigraphic cycles. The first two cycles are formed by siliciclastic rocks with fining up sequences and carbonates coquinas bivalves. The youngest cycle related to Alagoas age is a transgressive event represented by the presence of an evaporitic layer in the top (anhydrite). This study aims to characterize the reservoir Coqueiros Formation based on the analysis of 2D and 3D seismic data and well data-correlation profiles. The structural map of the top of coquinas reservoir indicates a curvilinear contour of Pampo Fault as described on the literature. This fault was interpreted on seismic data as a basement´s high, and it doesn´t show influence on the horizons above the top of Lagoa Feia Group. The Pampo fault is responsible for the division of the field into two blocks: the hanginwall in the West and the footwall to the East. This division is well marked on the reservoir´s isopach map where a greater thickness of reservoir is observed on the lower block. In the Southeast extreme of Badejo-Linguado-Pampo trend, on Pampo Field, the thick siliciclastic´s interval ends laterally to the basement, and its lower´s cycle forms a wedge, as consequence the carbonate-coquina overlaps directly the basement. Another implication of the higher and distal position of Pampo field is that the third cycle is absent, truncated by the unconformity pre-Macaé Group (Albian)

Avaliação de sistemas de pultrudados com diferentes tipos de matrizes para aplicação em cabos condutores

In the last decades it has been observed a substantial developing of the electrical energy demand in the societies all over the World. In consequence the electrical energy distribution companies are increasing the quantity of electrical energy through the electrical energy conductor cables, which had grown the sag in the towers of energy transmission. Furthermore, the construction of more transmission towers brings a lot of troubles due environmental protection laws. In this way, looking forward to increase the quantity of electrical energy transmitted through electrical cables conductors, reduce the need of constructing new transmission towers and the sag in them, we suggest in this work the replace of the traditional core of the conductors cables commonly used, made of steel, by a core made by a composite material, which one is made by carbon fibers pultruded with polymeric resins as matrix. In a order to evaluate if the resins more commonly used in structural composites can be applied as matrix to make possible to use the composite material as a core, we made carbon fibers systems pultruded with epoxy, phenolic and polyester resins as matrix and a mechanic and physic-chemistry characterization was done on the systems by Tensile and Poisson tests, differential sprobe calorimetry (DSC), thermogravimetric analysis (TGA) and Fourier transformed infrared spectroscopy (FTIR), following their correspondents standards

O palco dos excluídos: os bastidores e personagens do Albergue Noturno de Bauru

The “Albergue Noturno de Bauru” (Night Shelter of Bauru) is a social assistance entity mantained by the “Centro Espírita Amor e Caridade (CEAC)” in partnership with the “Secretaria do Bem Estar Social (SEBES)”, that aims to temporarily shelter migrants in town and people in homeless situation. Every day, about 50 people look for the Shelter, because of several reasons. Opened in 1951, the entity – the only public service that offers overnight stay in town - surpassed social transformations over the years and never stopped its work. With the opening of its new headquarters in July 2011, it also began to develop a systematic monitoring of some sheltered people, looking for the reintegration of them into the social context. All this work has made the Night Shelter accumulate many stories, especially from those people who have gone through or are still in it. Thus, this paper aims to present, through a non-fiction novel, this scenario, exposing the history and functioning of the Bauru Night Shelter, while exposing the lives of different people who are part of this universe. Through the monitoring of several night shifts, narrated in diary format, it was possible to understand how the service started, the dilemmas involved in their development and how sheltered and volunteers build this reality.

Efeito do diabetes sobre o crescimento puberal da próstata de rato: avaliação hormonal, imunocitoquímica e bioquímica

Adequate testosterone levels are necessary for the development, growth and maintenance of the male reproductive system. Testosterone deficiency is common in men with diabetes in whom it may contribute to impaired performance, with consequent reduction of the activity of the androgen regulated organs, such as the prostate. However, little attention has been given to the plasma dihydrotestosterone (DHT) level, the most potent androgen, nor to the expression of the androgen receptor (AR), insulin-like growth factor type I (IGF-1) and receptor (IGF-1R) in target tissues. Here, we investigated the effect of type I diabetes mellitus on DHT plasma levels and on prostate AR, IGF-1 and IGF-1R expression during rat pubertal growth. Diabetes was induced in prepubertal male rats through administration of streptozotocin (STZ; 40 mg/kg). Diabetic, diabetic treated with insulin, and age-matched control animals were killed by overdoses of pentobarbital. The ventral prostatic lobe (VP) was dissected, weighed and processed for immunohistochemistry for AR, IGF-1 e IGF-1R; plasma T and DHT levels were also determined. Hyperglycemia at puberty reduced VP weight gain to about 50% and plasma T level to about 80% of the control levels. In contrast there were no changes in plasma DHT levels. Insulin replacement restored the VP weight gain, but not the plasma T levels, which remained 90% below the ones of controls. Immunohistochemistry showed that AR, IGF-1 and IGF-1R expression in the prostate epithelial cells did not change with hyperglycemia or insulin replacement. Thus, the AR expression in the prostate epithelial cells appears to be regulated by DHT, and to a minor extent it also controls glandular growth

Proliferação e Morte Celular (Apoptose) avaliadas em ratos Lewis após tratamento com mistura de praguicidas em baixas doses

The use of pesticides in Brazil has intensified over the years. And since 2009 it was ranked as the largest market for pesticides worldwide. The consequential diffuse contamination of the environment is therefore due to the increasing number of chemicals of different classes, origins and modes of action. Little is known about the action of pesticides on human health in situations of co-exposure. Possible toxic effects are not restricted to agricultural and industrial workers, but also the general population that may be exposed continuously to its residues in food and water. Although these pesticides are mostly present in the environment at low doses, it must be considered that possible cumulative or synergistic effects may occur when there are concurrent or sustained exposure for two or more of these agents, which can lead to late manifestation of subclinical damages, sometimes irreversible. Thus, the specific objective of this study was to assess the effect of carcinogenesis promotion of a mixture of pesticides at low doses and analyze the phenomena of cell proliferation and apoptosis in rat liver. A total of 50 male Lewis rats was separated into 5 groups for 8 weeks in a medium term hepatocarcinogenesis model. The three different classes of pesticides (dieldrin, dicofol, endosulfan, dichlorvos and permethrin), whose residues were detected by ANVISA during the period from 2001 to 2005 in tomatoes cultures, were added to the feed of rats initiated to hepatocarcinogenesis with diethylnitrosamine (DEN- 200mg/kg ip). We used two different mixtures, one with no toxic effects at doses (MEX1) referring to the NOEL (no-observed-effect level) and another at doses LOEL / LEL / LOAEL (Lowest-observed-effect level / Lowest-effect level / Lowest -observed-adverse-effect level), to the installation of adverse effects (MEX2), derived from chronic studies. All animals ...(Complete abstract click electronic access below)

Readequação acessível em edifício hospitalar em Ribeirão Branco/SP: (proposta de readequação espacial do Hospital Municipal Maria Rosa Cardoso)

Um dos problemas enfrentados pelas cidades brasileiras, e que atinge inclusive as de pequeno porte, refere-se à questão hospitalar. A falta de adequação de espaços e equipamentos tem causado grandes problemas à qualidade de vida da população. A melhoria das condições hospitalares nas cidades tem como consequência o aumento na qualidade de vida urbana; e esta, por sua vez está relacionada à adoção de medidas específicas a adequação hospitalar ás normas técnicas vigentes. O objetivo desse trabalho é realizar uma proposta projetual de requalificação espacial do Hospital Municipal de Ribeirão Branco (SP), incorporando uma visão sobre todos os aspectos necessários para o desenvolvimento correto de um programa hospitalar. Este trabalho de conclusão de curso visa dar condições confortáveis e autônomas de acesso a todos os usuários dessa unidade de saúde, além de melhor suas condições funcionais, em termos de programa hospitalar. Além disso, a proposta buscará inserir o Hospital num contexto tecnológico mais recente, para atualizar e potencializar a eficiência dos tratamentos

As metamorfoses no espaço com o advento da Copa do Mundo no Brasil: estudos sobre o distrito de Itaquera-SP

The present work discuss the reproduction of the social relations from the point of view of the new urban production relations - having as empirical universe for analysis-, the Itaquera district in the Sao Paulo metropolis, with the advent of the World Cup in Brazil. Starting with the reading of a reality in movement, in which the analysis walks covering the dialectic relationship between space and society, where the first is translated into product and life reproduction condition, aiming to unveil the metamorphoses that will take place in the urban space with its consequent contradiction, what it may be the expanded capital reproduction concomitantly with the process that denounces a spoliation movement of the social space. With the society approval before these big architectural projects enabled by ideology, it’s determined the (re) production of artificial spaces of consumption, funded for the capital extension. The current stage that the capitalism reveals a space turned into mass consumption merchandise, consequence of the victory of the exchange value over the usage value, amalgamated in positive measures of expulsion/sweeping of low income socio-economic layers

Resposta da comunidade de formigas ao efeito de borda em paisagens de Cerrado

Uma das principais alterações ambientais decorrentes da ação antrópica é o efeito de borda, consequência direta da fragmentação, que altera condições microclimáticas nas bordas dos fragmentos. Este processo afeta a biodiversidade, interferindo na dinâmica das comunidades, tanto vegetais, quanto animais, alterando a composição e a estrutura das comunidades. Através da utilização de bioindicadores é possível compreender como alterações nos hábitats interferem nas comunidades locais, ou em processos ecológicos essenciais para a manutenção do ecossistema e da biodiversidade local ou regional. Devido à grande riqueza, abundância e importância em diversos processos ecológicos, como por exemplo, dispersão de sementes e ciclagem de nutrientes, as formigas têm sido utilizadas como indicadores ambientais. Os objetivos deste trabalho foram avaliar como as comunidades de formigas de fragmentos de cerrado respondem ao efeito de borda, especificamente se essa resposta ocorre de forma gradiente ou hábitat-matriz (formigas não estão presentes na borda). Também foi analisado se o tipo de matriz adjacente influencia nessas respostas observadas em 15 paisagens de cerrado circundadas por matrizes de pasto, cana-de-açúcar e eucalipto onde se utilizou armadilhas de queda ao longo de transectos posicionados tanto dentro como fora dos fragmentos. Para a riqueza total de formigas o modelo hábitat-matriz com interferência da matriz foi o que melhor explicou a distribuição. Os modelos que melhor explicaram a riqueza e abundância dos grupos funcionais variaram consideravelmente, o que evidencia a importância de buscar modelos mais complexos (modelo gradiente) que expliquem tanto as respostas mais simples (hábitat-matriz)como as mais multíplices. As comunidades analisadas apresentam diferentes funções dentro do hábitat e das matrizes, dessa forma participam de vários processos ecológicos sendo assim bons indicadores...

Medidas de adequação ambiental para indústria de leite e derivados, como requisito para gestão ambiental

The society continues demonstrating its need regarding the products and services, even though it becomes increasingly value the protection of the environment. In this context, environmental management is defined as a management method that emphasizes to continuously improve results and promote sustainable development. Moreover it has as a tool the laws which provide the benchmarks and mechanisms for companies to adapt their activities in such a way that does not alter the quality of the environment. In this sense, in order to propose improvements to a dairy aiming their environmental suitability, a present study was prepared by following the production activities of the enterprise, the raising of standards and applicable legal requirements and environmental assessment for the preparation of an array of aspects and impacts with the task of identifying the most significant according to MOREIRA (2006). The results indicated that some of the impacts of high relevance are related to the generation of wastewater and solid waste, which do not have treatment and / or proper disposal and indeed require intervention for their suitability. Through, these results were drawn up proposals for actions conformation. In addition, they were proposed meeting the requirement for health and safety at work, in accordance with the standard regulations. This study has the function, therefore, propose to the company in question, an environmental management plan that ensures the protection of the environment and health of employees and consequently the improvement of production processes and products