Rare earth complexes with Ge-132 and their catalytic hydrolysis to phosphatide bond of mononucleotide

The complexes of a series of rare earths with Ge-132 have been prepared. The carboxyl anions of Ge-132 molecule were coordinated to rare earth ion with chelate style. In the complexes molecule, the GeO3/2 group of Ge-132 were hydrolyzed to become -Ge(OH)(3) group, and later does:not coordinate with rare earth ions. All of the complexes possess similar properties. In aqueous solution of pH 6 and 50 degrees C, these complexes can obviously selectively catalytically hydrolize the phosphatide bond of 5'-AMP and 5'-dAMP into phosphatic acid and riboside.

Ge-132稀土配合物及其对单核苷酸磷酯键的催化水解作用

Ｇｅ－１３２是具有广泛生物活性的一元羧酸有机锗倍半氧化物的低聚物，分子中存在类似冠醚的Ｇｅ－Ｏ－Ｇｅ大环结构．因此，有人认为Ｇｅ－１３２的生物活性可能与这种大环结构与体内金属离子形成配合物有关［１］，但尚无直接的实验证据．因此，合成Ｇｅ－１３２稀土配…