Pieces of Iowa’s Past, January 28,2009

Pieces of Iowa’s Past, published by the Iowa State Capitol Tour Guides weekly during the legislative session, features historical facts about Iowa, the Capitol, and the early workings of state government. All historical publications are reproduced here with the actual spelling, punctuation, and grammar retained. January 28, 2009 THIS WEEK: Alfred Piquenard, Designer of the Iowa State Capitol

Pieces of Iowa’s Past, March 28, 2012

Pieces of Iowa’s Past, published by the Iowa State Capitol Tour Guides weekly during the legislative session, features historical facts about Iowa, the Capitol, and the early workings of state government. All historical publications are reproduced here with the actual spelling, punctuation, and grammar retained. THIS WEEK: Electric Lighting in the Iowa State Capitol BACKGROUND: REPORT OF COMMITTEE ON LIGHTING THE BUILDING AND GROUNDS WITH ELECTRICITY—1882 The Capitol Commissioners submitted biennial reports throughout the 15 years it took to build the Capitol (1871-1886). Often there were committees formed to investigate a certain phase of the construction. The following is the report of the Committee on Lighting. Note: The Capitol Commissioners determined the gas lighting to be the best choice in the 1880s. Less than 20 years later, the process began to convert the Capitol from gas to electric lighting. There was a period where both types of lighting were being used in the Capitol. The photograph of the 1904 apple harvest shows both electric and gas fixtures. The turn of the 20th century photograph of the library also shows chandeliers utilizing both gas and electricity. The photograph of the single fixture in the library is a mystery. It shows a fixture utilizing both gas and electricity, but no other photographs of the library exist where this fixture appears. Perhaps it was a prototype and never used in the Capitol.

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overactivation of microglial cells, which may contribute to an inappropriate proinflammatory response leading to vasogenic edema and cerebral microhemorrhage. Here, we describe the generation of a humanized anti-Aβ monoclonal antibody of an IgG4 isotype, known as MABT5102A (MABT). An IgG4 subclass was selected to reduce the risk of Fcγ receptor-mediated overactivation of microglia. MABT bound with high affinity to multiple forms of Aβ, protected against Aβ1-42 oligomer-induced cytotoxicity, and increased uptake of neurotoxic Aβ oligomers by microglia. Furthermore, MABT-mediated amyloid plaque removal was demonstrated using in vivo live imaging in hAPP((V717I))/PS1 transgenic mice. When compared with a human IgG1 wild-type subclass, containing the same antigen-binding variable domains and with equal binding to Aβ, MABT showed reduced activation of stress-activated p38MAPK (p38 mitogen-activated protein kinase) in microglia and induced less release of the proinflammatory cytokine TNFα. We propose that a humanized IgG4 anti-Aβ antibody that takes advantage of a unique Aβ binding profile, while also possessing reduced effector function, may provide a safer therapeutic alternative for passive immunotherapy for AD. Data from a phase I clinical trial testing MABT is consistent with this hypothesis, showing no signs of vasogenic edema, even in ApoE4 carriers.

I yineka pou skotoni / Paul Gad et Aleco Ahiadis, duo voc. [acc. mandolines et p]. Cardherina Que Florouss / Paul Gad, chant [acc. choeur et instr.]

[Traditions. Europe. Grèce]

To palatti this aghapis / Paul Gad et Aleco Ahiadis, duo voc. [acc. mandolines et p]. Horriss cardia / Paul Gad, chant [acc. choeur et instr.]

[Traditions. Europe. Grèce]

Glikia régina / Paul Gad et Aleco Ahiadis, duo voc. [acc. mandolines et p]. I accro thalassia / Paul Gad, Aleco Ahiadis, duo voc. [acc. instr.]

[Traditions. Europe. Grèce]

Les natures mortes de Paul Gauguin: une production picturale méconnue

Gauguin's first attempts at still-life painting, around 1875, followed the Dutch tradition, influenced mainly by Manet's palette. But he did take occasional liberties in depicting flowers with more fluid colour and dynamic backgrounds. From 1879 his style shows the influence of the Impressionists: Pissarro in the landscapes and Degas in the composition of his still-lifes. He was also open to the new trends which were developing among artists in Paris and applied them in his paintings, using still-lifes as his main means for testing them. He did not escape the contemporary fascination with Japonism, and even experimented briefly with Pointillism in Still Life with Horse's Head. His stays in Britain between 1886 and 1890 correspond to an extremely rich and innovative period for him, in which still-lifes served for increasing experimentation. "Fête Gloanec" and Three Puppies reflect his preoccupations: rejection of perspective, use of areas of flat colour, and mixed styles. These pictures amount to an aesthetic manifesto; many of them are also imbued with strong symbolism, as in the Portrait of Meyer de Haan, which is a melancholic reflection on the fall of man. In Still-Life with Japanese Print, frail blue flowers seem to come out of the head of the artist-martyr, a pure product of the painter's "restless imagination". Thus Gauguin showed that art is an "abstraction" through a genre which was reputed to lend itself with difficulty to anything other than mimesis. Although he moved away from still-life after 1890, Gauguin is one of the first artists to radically renew its role and the status of still-life at the end of the 19th century, well before the Fauvists and Cubists.

Mi nostalgia / Paul Gad et Aleco Ahiadis, duo voc. [acc. mandolines et p]. Coquetta / Paul Gad, chant [acc. choeur et instr.]

[Traditions. Europe. Grèce]

Yasmina / Paul Gad [acc. mandolines et p]. Tha fio corri sta xéna / Paul Gad, chant [acc. choeur et instr.]

[Traditions. Europe. Grèce]