Iowa Community Empowerment Newsletter, October 2003, Vol. 4, No. 6

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, August 2003, Vol. 4, no. 5

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, July 2003, Vol. 4, no. 3

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, April 2003, Vol 4, no. 4

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, February 2003, Vol. 4, no. 1

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, August 2002, Vol. 3, no. 4

Monthly newsletter for the Iowa Department of Public Health

Iowa Community Empowerment Newsletter, August 2001, Vol. 2, no. 4

Monthly newsletter for the Iowa Department of Public Health

VIP Connection Newsletter, August 2004, Vol. 4, no 3.

Iowa Lottery Player Newsletter

Quantification of 4 antidepressants and a metabolite by LC-MS for therapeutic drug monitoring.

A liquid chromatography method coupled to mass spectrometry was developed for the quantification of bupropion, its metabolite hydroxy-bupropion, moclobemide, reboxetine and trazodone in human plasma. The validation of the analytical procedure was assessed according to Société Française des Sciences et Techniques Pharmaceutiques and the latest Food and Drug Administration guidelines. The sample preparation was performed with 0.5mL of plasma extracted on a cation-exchange solid phase 96-well plate. The separation was achieved in 14min on a C18 XBridge column (2.1mm×100mm, 3.5μm) using a 50mM ammonium acetate pH 9/acetonitrile mobile phase in gradient mode. The compounds of interest were analysed in the single ion monitoring mode on a single quadrupole mass spectrometer working in positive electrospray ionisation mode. Two ions were selected per molecule to increase the number of identification points and to avoid as much as possible any false positives. Since selectivity is always a critical point for routine therapeutic drug monitoring, more than sixty common comedications for the psychiatric population were tested. For each analyte, the analytical procedure was validated to cover the common range of concentrations measured in plasma samples: 1-400ng/mL for reboxetine and bupropion, 2-2000ng/mL for hydroxy-bupropion, moclobemide, and trazodone. For all investigated compounds, reliable performance in terms of accuracy, precision, trueness, recovery, selectivity and stability was obtained. One year after its implementation in a routine process, this method demonstrated a high robustness with accurate values over the wide concentration range commonly observed among a psychiatric population.

The Lunch Line, Vol. 52, no. 4, March 2002

Newsleter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Vol. 52, no. 4, April 2003

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Security Blanket, December 2001, Vol.1, no.4

Newsletter for Information Technology Department