Avaliação gastroprotetora da epicatequina e verificação de seus mecanismos de ação

The stomach is an exceptional organ, which functions are sterilize food ingested, form the primitive bolus, digest lipids and proteins, and to store food temporarily in the gastrointestinal tract. Its capacity of digesting food without digesting itself is amazing. This fact occurs due to innumerous protective substances adjacent to the gastric mucosa. When aggressive factors overwhelm the protective factors, a lesion in the gastric mucosa is formed. Lesions that reach the lamina propria are called gastric ulcers, which are classified macroscopically as openings on the gastric wall and; microscopically, as a gastric injury characterized with epithelial desquamation, mucosal hemorrhage, glandular damage and eosinophilic infiltration. The current therapy available is effective, although it causes collateral effects, therefore researching new drugs is necessary. This work aim to evaluate the gastroprotective effect of epicatechin against gastric lesions induced by absolute ethanol and non steroidal anti-inflammatory drugs which are the main causes of this disease currently, yet we aim to study the main mechanisms of action responsible for the gastroprotective effect. The results show that epicatechin has a significant macroscopic and microscopic gastroprotective effect against gastric injuries induced by ethanol and indomethacin, acting locally by augmenting gastric mucus secretion and it also acts via antioxidant system by holding total glutathione levels. Epicatechin’s gastroprotective mechanisms depend on the activation of sulfhydryl compounds and doesn’t depend on the NO-synthase enzyme

Avaliação do potencial antioxidante, citotóxico e fotoprotetor de extratos de Hymenaea courbaril L. e Hymenaea stigonocarpa Mart. ex Hayne

Pós-graduação em Biociências - FCLAS

Aspectos clínicos, histopatológicos e expressão gênica do endométrio de cadelas acometidas por hiperplasia endometrial cística, mucometra e piometra

Pós-graduação em Cirurgia Veterinária - FCAV

Avaliação dos aspectos da dieta alimentar de Pimelodus maculatus em dois importantes tributários do reservatório de Jurumirim, Alto Rio Paranapanema-SP

The species Pimelodus maculatus is one of the most abundant fish in many artificial reservoirs. Shows feeding plasticity and exploits all trophic levels in aquatic ecosystems. This study aimed to analyze and compare aspects of the diet of P. maculatus in two important tributaries (Taquari and Veados rivers) in the upper Paranapanema River system, and also investigate possible differences in the condition factor using its feeding habit as reference. Samplings were carried out every three months during 2011 and 2012 in two tributaries of Jurumirim's dam. After biometric analysis, fish were dissected to remove the stomachs that were fixed in formaldehyde 10% and conserved in alcohol 70%. The stomach content was analyzed under stereomicroscope and the food items were identified until the least possible taxonomic level. The diet was characterized based on the Alimentary Index (IAi). Feeding strategy and aspects of species autoecology were evaluated by the relation between abundance of prey-specific (Pi) and occurrence frequency (Fo) of the prey, and also was calculated the niche width of Levin (B). The condition factor was also established and values obtained in samples of both rivers were compared, correlating them with diet of the species

Dopplerfluxometria e avaliação morfométrica do fígado, baço, rins e grandes vasos abdominais de onças pardas (Puma concolor) da região Campo Grande, Mato Grosso do Sul, Brasil

Pós-graduação em Biotecnologia Animal - FMVZ

Relação entre materiais dentários e o complexo dentino-pulpar

Despite the strong valorization of the esthetics and its relationship with restorative materials, the biological principles of any clinical procedure are extremely important to maintain the vitality of the dentin-pulp complex. Dentin and pulp tissue are susceptible to different kinds of irritants such as toxins from microorganisms, traumatic procedures of cavity preparation, as well as toxic components released by restorative materials applied in non recommended clinical situations. Initially, the pulp responds to irritation by starting an inflammatory reaction which involves outward movement of dentinal fluid and intratubular deposition of immunoglobulins, upregulation of odontoblast activities, presence of immune cells and their cytokines as well as local expression of neuropeptides and chemokines. After these initial events, the inflammation process can be resolved associated or not to sclerotic dentin formation and reactionary dentin deposition. If high intensity offensive stimuli are applied to the dentin-pulp complex, death of odontoblasts takes place and consequently pulp ageing or even partial necrosis of this tissue may occurs. Thereby, clinicians need to be aware about the physiological and pathological features of the dentin-pulp complex as well as the possible biological consequences of different clinical procedures. In this way, the dentists should be able to carry out minimally aggressive operative techniques and to select the more appropriate restorative materials for each specific clinical situation in order to obtain excellent clinical results associated to the maintenance of pulp vitality.

Estado actual del blanqueamiento: sigue siendo un tratamiento seguro? review

The demand for cosmetic dentistry, including teeth whitening, has increased in recent years. The home teeth whitening and in-office, are widely used in dental practice. The mechanism by which it works is by oxidation of the chromogenic existing tooth structure. This is an effective and minimally invasive procedure that achieves tooth lighten the color, however, may cause alterations in the enamel surface, such as a dental permeability increase. Another effect caused by this procedure is tooth sensitivity, being the most common side effect, up to 65% of individuals have had a secondary effect at least once during treatment. This sensitivity and gingival irritation caused by bleaching may vary depending on the patient and used bleaching product