Circadian control of tissue homeostasis and adult stem cells.

The circadian timekeeping mechanism adapts physiology to the 24-hour light/dark cycle. However, how the outputs of the circadian clock in different peripheral tissues communicate and synchronize each other is still not fully understood. The circadian clock has been implicated in the regulation of numerous processes, including metabolism, the cell cycle, cell differentiation, immune responses, redox homeostasis, and tissue repair. Accordingly, perturbation of the machinery that generates circadian rhythms is associated with metabolic disorders, premature ageing, and various diseases including cancer. Importantly, it is now possible to target circadian rhythms through systemic or local delivery of time cues or compounds. Here, we summarize recent findings in peripheral tissues that link the circadian clock machinery to tissue-specific functions and diseases.

Special investigation of the Iowa Department of Transportation for the period January 29, 1994 through July 7, 2011

Special investigation of the Iowa Department of Transportation for the period January 29, 1994 through July 7, 2011

Special investigation of the University of Northern Iowa Events Complex Concessions for the period October 1, 2006 through March 31, 2012

Special investigation of the University of Northern Iowa Events Complex Concessions for the period October 1, 2006 through March 31, 2012

Report on a special investigation of the City of Indianola for the period June 1, 2006 through August 31, 2012

Report on a special investigation of the City of Indianola for the period June 1, 2006 through August 31, 2012

Report on a special investigation of the Lyon County Engineer’s Office for the period August 1, 2006 through May 31, 2012

Report on a special investigation of the Lyon County Engineer’s Office for the period August 1, 2006 through May 31, 2012

The puzzles of the prokineticin 2 pathway in human reproduction.

Prokineticin, 1 (PROK1) and prokineticin 2 (PROK2), are two closely related proteins that were identified as the mammalian homologs of their two amphibian homologs, mamba intestinal toxin (MIT-1) and Bv8. MIT-1 was initially identified as a non-toxic constituent in the venom of the black mamba snake (Dendroaspis polylepis) (Joubert and Strydom, 1980) while Bv8 was identified in the skin secretion of the toad, Bombina variegate (Mollay et al., 1999). All three homologs stimulate gastrointestinal motility thus accounting for their family name "prokineticins" (Schweitz et al., 1990, 1999). However, since its initial description, both PROK1 and PROK2 have been found to regulate a dazzling array of biological functions throughout the body. In particular, PROK1 acts as a potent angiogenic mitogen on endocrine vascular epithelium, thus earning its other name, Endocrine gland-vascular endothelial factor (EG-VEGF) (LeCouter et al., 2002). In contrast, the PROK2 signaling pathway is a critical regulator of olfactory bulb morphogenesis and sexual maturation in mammals and this function is the focus of this review.

Report on a special investigation of the Creston Water Works for the period July 1, 2005 through November 16, 2012

Report on a special investigation of the Creston Water Works for the period July 1, 2005 through November 16, 2012

EPI Update: Special Alert, July 3, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health. SPECIAL ALERT

EPI Update: Special Alert, July 8, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health. SPECIAL ALERT

Report on special investigation of the Department of Inspections and Appeals, Office of the State Public Defender, for the period August 31, 2007 through March 31, 2011

Report on a special investigation of the State Public Defender’s Office for the period August 31, 2007 through March 31, 2011

EPI Update: Special Alert, July 12, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health. SPECIAL ALERT

EPI Update: Special Alert, July 19, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health. SPECIAL ALERT

Report on special investigation of the City of Farmington for the period July 1, 2009 through November 30, 2012

Special investigation of the City of Farmington for the period July 1, 2009 through November 30, 2012

Report on a special investigation of the City of Grand River for the period July 1, 2004 through March 7, 2012

Report on a special investigation of the City of Grand River for the period July 1, 2004 through March 7, 2012