La Carelie, et l'Ingrie, ou Ingermenland. Par le s.r Sanson geogr'. ord.re du roy.

[N. 1:875000].

Russie européenne, partie septentrionale. Deuxieme carte.

Vasemmassa alakulmassa: Tardieu sculp. - Oikeassa alakumassa: André scrip.

Evropa ad magnae Europae Gerardi Mercatoris p. imitationem, Rumoldi Mercatoris f. cura edita, seruato tamen initio longitudinis ex ratione magnetis, quod pater in magna sua vniuersali posuit.

Mittakaavaa ei määritelty ;

Gemeine Beschreibung aller Mitnächtigen Länder, alsz Schweden, Gothen, Norwegien, Dennmarck, [et]c.

Koordinaatisto vain kartan yläreunassa: Parall. 80 gradus Latt. ; 350°-06° [po. 60°].

[Topografičeskaâ karta 1:42000]. IX-51, IX-52, VIII-51, VIII-52, Vyb. gub., Strandsk. i Èurâp. uĕzd. / snimali S̆estakov" i Habarov" ; c̆ertil" S̆...kov".

[1:42000].

De sacris Moloch Jer: XXXII. v. 35

Variantti B.

De spiritu in genere

Invokaatio: D.D.

Meditationes sanctarum epistolarum 55

Invokaatio: Deo duce.

Antinociceptive effects of the essential oil of Mentha x villosa leaf and its major constituent piperitenone oxide in mice

Mentha x villosa Huds (Labiatae) is an aromatic herb widely used in folk medicine. Since the essential oil of the herb has many pharmacological activities, including antispasmodic effects, we determined whether the oil and its major constituent, piperitenone oxide (PO), have antinociceptive activity. The essential oil of M. x villosa (EOMV) and PO administered orally at 200 mg/kg (vehicle: 0.1% Tween 80 in water) significantly reduced the writhings induced by acetic acid from control values of 59.5 ± 3.1 s (N = 10) to 31.9 ± 2.8 s (N = 10) and 23.8 ± 3.4 s (N = 10), respectively. When administered at 100 and 200 mg/kg, EOMV reduced the paw licking time for the second phase of the formalin test from the control value of 20.6 ± 2.1 s (N = 13) to 5.3 ± 2.2 s (N = 12) and 2.7 ± 1.2 s (N = 18), respectively. At 100 and 200 mg/kg, PO reduced this second phase to 8.3 ± 2.7 s (N = 12) and 3.0 ± 1.2 s (N = 10), respectively. This effect of EOMV and PO was not reversed by naloxone. EOMV and PO had no significant effect on the first phase of the formalin test. As evaluated by the hot-plate and tail immersion test, EOMV and PO, at doses up to 200 mg/kg, showed no analgesic activity. These results show that EOMV and PO have antinociceptive activity and suggest that this effect is probably an indirect anti-inflammatory effect, which does not involve the central nervous system.

Index & judex syncretismorum 8

Invokaatio: In nomine Jesu!

Fasciculus physicae ejusdem illustriores definitiones, divisiones, atque nobiliores controversias axiomatibus nonnullis insertas brevibusque rationibus firmatas ac enodatas continens

Arkit: 4 arkintunnuksetonta lehteä, A-F8 G4.

De effectibus fascino naturalibus

Invokaatio: I.N.J.

Effects of sirolimus alone or in combination with cyclosporine A on renal ischemia/reperfusion injury

Calcineurin inhibitors exacerbate ischemic injury in transplanted kidneys, but it is not known if sirolimus protects or exacerbates the transplanted kidney from ischemic injury. We determined the effects of sirolimus alone or in combination with cyclosporin A (CsA) on oxygenated and hypoxic/reoxygenated rat proximal tubules in the following in vitro groups containing 6-9 rats per group: sirolimus (10, 50, 100, 250, 500, and 1000 ηg/mL); CsA (100 µg/mL); sirolimus (50 and 250 ηg/mL) + CsA (100 µg/mL); control; vehicle (20% ethanol). For in vivo studies, 3-week-old Wistar rats (150-250 g) were submitted to left nephrectomy and 30-min renal artery clamping. Renal function and histological evaluation were performed 24 h and 7 days after ischemia (I) in five groups: sham, I, I + SRL (3 mg·kg-1·day-1, po), I + CsA (3 mg·kg-1·day-1, sc), I + SRL + CsA. Sirolimus did not injure oxygenated or hypoxic/reoxygenated proximal tubules and did not potentiate the tubular toxic effects of CsA. Neither drug affected the glomerular filtration rate (GFR) at 24 h. GFR was reduced in CsA-treated rats on day 7 (0.5 ± 0.1 mL/min) but not in rats receiving sirolimus + CsA (0.8 ± 0.1 mL/min) despite the reduction in renal blood flow (3.9 ± 0.5 mL/min). Acute tubular necrosis regeneration was similar for all groups. Sirolimus alone was not toxic and did not enhance hypoxia/reoxygenation injury or CsA toxicity to proximal tubules. Despite its hemodynamic effects, sirolimus protected post-ischemic kidneys against CsA toxicity.

De vera indole et ratione officiorum perfectorum

Dedikaatio: Johannes Henr. Lindquist.

De temperantia

Variantti A.