Hellas seu Graecia Universa / autore J. Laurenbergio

Échelle(s) : [1:2 110 000 ca] Milliaria Italica Communia 80 = [7 cm]

Population pharmacokinetic study of memantine: effects of clinical and genetic factors.

BACKGROUND AND OBJECTIVE: Memantine, a frequently prescribed anti-dementia drug, is mainly eliminated unchanged by the kidneys, partly via tubular secretion. Considerable inter-individual variability in plasma concentrations has been reported. We aimed to investigate clinical and genetic factors influencing memantine disposition. METHODS: A population pharmacokinetic study was performed including data from 108 patients recruited in a naturalistic setting. Patients were genotyped for common polymorphisms in renal cation transporters (SLC22A1/2/5, SLC47A1, ABCB1) and nuclear receptors (NR1I2, NR1I3, RXR, PPAR) involved in transporter expression. RESULTS: The average clearance was 5.2 L/h with a 27 % inter-individual variability (percentage coefficient of variation). Glomerular filtration rate (p = 0.007) and sex (p = 0.001) markedly influenced memantine clearance. NR1I2 rs1523130 was identified as the unique significant genetic covariate for memantine clearance (p = 0.006), with carriers of the NR1I2 rs1523130 CT/TT genotypes presenting a 16 % slower memantine elimination than carriers of the CC genotype. CONCLUSION: The better understanding of inter-individual variability of memantine disposition might be beneficial in the context of individual dose optimization.

Hellas seu Graecia Universa / autore J. Laurenbergio

Échelle(s) : [1:2 110 000 ca] Milliaria Italica Communia 80 = [7 cm]

Hellas seu Graecia Universa / autore J. Laurenbergio

Échelle(s) : [1:2 110 000 ca] Milliaria Italica Communia 80 = [7 cm]

Achaiae nova & accurata descriptio / autore I. Laurenbergio

Échelle(s) : [1:1 000 000 ca] Mil. Germ. 7 [= 4,8 cm], Mil. Gall. 9 [= 4,6 cm], Mil. Ital. 28 [= 4,8 cm], Stadia 250 [= 4,5 cm] (d'après échelles graphiques).

Peloponnesus, sive Morea / Auth. I. Laurenbergio

Échelle(s) : [1:1 000 000 ca] Mil. Germ. 8 [= 5,5 cm], Mil. Gall. 10 [= 5,2 cm], Mil. Ital. 30 [= 5,5 cm], Stadia 300 [= 5,5 cm] (d'après échelles graphiques)

La bella molinera

Aquest treball vol ser una aproximació a l’obra Die schöne Müllerin, D795, un cicle de vint cançons per a veu i piano, que Franz Schubert va compondre l’any 1823. L’obra es basa en un conjunt de poemes que havia escrit poc abans Wilhelm Müller, i que expliquen la història del desengany amorós d’un jove aprenent de moliner. La bella molinera presenta un ventall infinit de colors, emocions, paisatges... Va des de l’alegria més eufòrica fins a la desesperança més fonda, passant per moments d’ironia, de somnis i de sorpreses. Tot això és analitzat en el treball, número per número, tan en l’aspecte literari com en el musical, i en la seva interrelació.