983 resultados para Turgenev, Ivan Sergeevich, 1818-1883
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von Hans Meyer
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Fil: Karczmarczyk, Pedro. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.
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Fil: Arce, María Eray. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.
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The blowflies Chrysomya chloropyga (Wiedemann,1818) and Chrysomya putoria (Wiedemann, 1830) (Diptera: Calliphoridae) of veterinary and medical importance are taxonomically revised and formally reestablished as two different species. Characters in the adult morphology by which they can be distinguished, including characters in the genitalia, are described. The form with a darkened anterior margin of the wing, 'f. tacniata Bigot' sensu Zumpt 1956, is treated as a variant of C. putoria. In order to preserve stability of nomenclature, lectotypes are designated for both nominal species, fixing their identity in accordance with current usage. Somomyia cuprinitens Rondani, 1873, and Somomyia taeniata Bigot, 1877, (= C. chloropyga 'f. taeniata Bigot' of Zumpt) are considered new synonyms of C. putoria.
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PURPOSE: To compare the efficacy and safety of ranibizumab and bevacizumab intravitreal injections to treat neovascular age-related macular degeneration (nAMD). DESIGN: Multicenter, noninferiority factorial trial with equal allocation to groups. The noninferiority limit was 3.5 letters. This trial is registered (ISRCTN92166560). PARTICIPANTS: People >50 years of age with untreated nAMD in the study eye who read =25 letters on the Early Treatment Diabetic Retinopathy Study chart. METHODS: We randomized participants to 4 groups: ranibizumab or bevacizumab, given either every month (continuous) or as needed (discontinuous), with monthly review. MAIN OUTCOME MEASURES: The primary outcome is at 2 years; this paper reports a prespecified interim analysis at 1 year. The primary efficacy and safety outcome measures are distance visual acuity and arteriothrombotic events or heart failure. Other outcome measures are health-related quality of life, contrast sensitivity, near visual acuity, reading index, lesion morphology, serum vascular endothelial growth factor (VEGF) levels, and costs. RESULTS: Between March 27, 2008 and October 15, 2010, we randomized and treated 610 participants. One year after randomization, the comparison between bevacizumab and ranibizumab was inconclusive (bevacizumab minus ranibizumab -1.99 letters, 95% confidence interval [CI], -4.04 to 0.06). Discontinuous treatment was equivalent to continuous treatment (discontinuous minus continuous -0.35 letters; 95% CI, -2.40 to 1.70). Foveal total thickness did not differ by drug, but was 9% less with continuous treatment (geometric mean ratio [GMR], 0.91; 95% CI, 0.86 to 0.97; P = 0.005). Fewer participants receiving bevacizumab had an arteriothrombotic event or heart failure (odds ratio [OR], 0.23; 95% CI, 0.05 to 1.07; P = 0.03). There was no difference between drugs in the proportion experiencing a serious systemic adverse event (OR, 1.35; 95% CI, 0.80 to 2.27; P = 0.25). Serum VEGF was lower with bevacizumab (GMR, 0.47; 95% CI, 0.41 to 0.54; P
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Digitization offers excellent opportunities for the preservation and safe-keeping of valuable library collections. The article recounts the first coordinated attempts of “Ivan Vazov” Public Library – Plovdiv at digitizing some of its treasured collections such as manuscripts, early printed books and archives through partner projects and revealing them to the world community.
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PURPOSE: To describe changes in intraocular pressure (IOP) in the 'alternative treatments to Inhibit VEGF in Age-related choroidal Neovascularisation (IVAN)' trial (registered as ISRCTN92166560). DESIGN: Randomised controlled clinical trial with factorial design. PARTICIPANTS: Patients (n=610) with treatment naïve neovascular age-related macular degeneration were enrolled and randomly assigned to receive either ranibizumab or bevacizumab and to two regimens, namely monthly (continuous) or as needed (discontinuous) treatment. METHODS: At monthly visits, IOP was measured preinjection in both eyes, and postinjection in the study eye. OUTCOME MEASURES: The effects of 10 prespecified covariates on preinjection IOP, change in IOP (postinjection minus preinjection) and the difference in preinjection IOP between the two eyes were examined. RESULTS: For every month in trial, there was a statistically significant rise in both the preinjection IOP and the change in IOP postinjection during the time in the trial (estimate 0.02 mm Hg, 95% CI 0.01 to 0.03, p<0.001 and 0.03 mm Hg, 95% CI 0.01 to 0.04, p=0.002, respectively). There was also a small but significant increase during the time in trial in the difference in IOP between the two eyes (estimate 0.01 mm Hg, 95% CI 0.005 to 0.02, p<0.001). There were no differences between bevacizumab and ranibizumab for any of the three outcomes (p=0.93, p=0.22 and p=0.87, respectively). CONCLUSIONS: Anti-vascular endothelial growth factor agents induce increases in IOP of small and uncertain clinical significance.
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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.
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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.
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Este trabajo explora las estrategias utilizadas para financiar la creación y el sostenimiento del Ejército de los Andes y los instrumentos fiscales utilizados para conseguirlo. El análisis de los distintos rubros que integraban las cajas del ejército permite examinar el peso de los recursos aportados por el gobierno central y por la jurisdicción cuyana. Asimismo, analiza el destino de los fondos a través del estudio de los presupuestos del ejército, con el objetivo de ponderar el peso que tuvieron los salarios en el total de los gastos militares durante la etapa previa al cruce de los Andes, y en la posterior, cuando el ejército estaba en Chile bajo severas condiciones fiscales de los gobiernos patriotas.
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Este trabajo explora las estrategias utilizadas para financiar la creación y el sostenimiento del Ejército de los Andes y los instrumentos fiscales utilizados para conseguirlo. El análisis de los distintos rubros que integraban las cajas del ejército permite examinar el peso de los recursos aportados por el gobierno central y por la jurisdicción cuyana. Asimismo, analiza el destino de los fondos a través del estudio de los presupuestos del ejército, con el objetivo de ponderar el peso que tuvieron los salarios en el total de los gastos militares durante la etapa previa al cruce de los Andes, y en la posterior, cuando el ejército estaba en Chile bajo severas condiciones fiscales de los gobiernos patriotas.
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Este trabajo explora las estrategias utilizadas para financiar la creación y el sostenimiento del Ejército de los Andes y los instrumentos fiscales utilizados para conseguirlo. El análisis de los distintos rubros que integraban las cajas del ejército permite examinar el peso de los recursos aportados por el gobierno central y por la jurisdicción cuyana. Asimismo, analiza el destino de los fondos a través del estudio de los presupuestos del ejército, con el objetivo de ponderar el peso que tuvieron los salarios en el total de los gastos militares durante la etapa previa al cruce de los Andes, y en la posterior, cuando el ejército estaba en Chile bajo severas condiciones fiscales de los gobiernos patriotas.
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The Journal has been Queen's main student newspaper since it was founded in 1873. It appears twice a week on campus with a mix of news, sports, and entertainment stories, editorials, letters to the editor, and photographs. The paper is students' most important source of news and general information and has been a training ground for scores of Canadian journalists.
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The Journal has been Queen's main student newspaper since it was founded in 1873. It appears twice a week on campus with a mix of news, sports, and entertainment stories, editorials, letters to the editor, and photographs. The paper is students' most important source of news and general information and has been a training ground for scores of Canadian journalists.