When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study.

OBJECTIVE To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). DESIGN Prospective studies of HIV-positive individuals in Europe and the USA in the HIV-CAUSAL Collaboration and The Center for AIDS Research Network of Integrated Clinical Systems. METHODS Antiretroviral-naive individuals who initiated ART and became virologically suppressed within 12 months were followed from the date of suppression. We compared 3 CD4 cell count and HIV-RNA monitoring strategies: once every (1) 3 ± 1 months, (2) 6 ± 1 months, and (3) 9-12 ± 1 months. We used inverse-probability weighted models to compare these strategies with respect to clinical, immunologic, and virologic outcomes. RESULTS In 39,029 eligible individuals, there were 265 deaths and 690 AIDS-defining illnesses or deaths. Compared with the 3-month strategy, the mortality hazard ratios (95% CIs) were 0.86 (0.42 to 1.78) for the 6 months and 0.82 (0.46 to 1.47) for the 9-12 month strategy. The respective 18-month risk ratios (95% CIs) of virologic failure (RNA >200) were 0.74 (0.46 to 1.19) and 2.35 (1.56 to 3.54) and 18-month mean CD4 differences (95% CIs) were -5.3 (-18.6 to 7.9) and -31.7 (-52.0 to -11.3). The estimates for the 2-year risk of AIDS-defining illness or death were similar across strategies. CONCLUSIONS Our findings suggest that monitoring frequency of virologically suppressed individuals can be decreased from every 3 months to every 6, 9, or 12 months with respect to clinical outcomes. Because effects of different monitoring strategies could take years to materialize, longer follow-up is needed to fully evaluate this question.

Die Frage der Organisation des Milchabsatzes

Harry Viteles

Die Traubenkultur

Harry Viteles

Die kooperative Bewegung unter den Juden in Palästina

Harry Viteles

Die Mandelkultur in Palästina

Harry Viteles

Die Zitrus-Industrie in Palästina

Harry Viteles

Das Gebet um Tau : zum Passahfeste

Harry Levy

Das Chanukafest im Spiegel der rabbinischen Literatur

Harry Levy

Alfred Jeremias [Rezension]

Harry Levy

Abbitte des "Jewish Chronicle"

Harry R. Lewis

Craniofacial Adaptations After Total Maxillary Osteotomy in Macaca Irus: A Cephalometric and Histologic Study

Submitted in partial fulfillment of the requirements for a Certificate in Orthodontics, Dept. of Orthodontics, University of Connecticut Health Center, 1977

Paths to Power: The Ascendance of Contemporary Democratic Congressional Leaders

Congressional leadership is a constantly changing phenomenon. New factors and actors are constantly affecting and altering which members ascend to positions of leadership and how that leadership is exercised. A critical change that has occurred in recent times is the inclusion of women in the congressional leadership for the first time. While there has been a great deal of theoretical work on gender and on congressional leadership, there have not been enough actual female leaders in Congress to perform a study until now. The present study examines the impact of gender, committee/legislative performance, ideology, and fundraising ability on leadership ascendancy. The variables are investigated through a comparative case study of Rep. Nancy Pelosi, Rep. Rosa DeLauro, Sen. Hillary Clinton and Sen. Harry Reid.

Ein Interview mit Sir H. H. Johnston über Ostafrika

Harry H. Johnston

Sir Johnstons Brief an die "Times"

Harry H. Johnston