Louisa (Isa) Gottschalk nee Rosenthal.

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Family portrait of the Gottschalk family; Hannover, Germany.

Front Row (l-r): Frau Steinfeld (mother of Elizabeth Gottschalk nee Steinfeld and Hela Steinfeld), Fritz Gottschalk, Karl Gottschalk, Henrietta Gottschalk nee Rothschild (mother of Fritz, Karl, Anna and Ernst), Anna Catsenstein nee Gottschalk (twin of Karl Gottschalk), and Elizabeth Gottschalk; Back Row (l-r): Hela Steinfeld (sister of Elizabeth Gottschalk nee Steinfeld), Therese Gottschalk nee Molling (wife of Fritz), Leo Catsenstein (husband of Anna), Elizabeth Gottschalk nee Steinfeld (wife of Karl), Ernst Gottschalk, and Henny Molling nee Meyerhof (mother of Therese Gottschalk nee Molling)

Studio portrait of the six daughters of Solomon and Emilie Kohnberger: (l-r) Laura, Irene, Johanna, Melanie, Hermine and Martha.

Laura (1878-1917) died during a flu epidemic. She married Sigmund Stiassny and had two children, Lisbeth (Gersuny) (1900-1986) and Walter (1902-1912) who died of a ruptured appendix.

Kohnberger family portrait.

From left to right, back row: Ernst Schueller, Hermine Schueller, Laura Stiassny, Sigmund Stiassny, Martha Pollak, Johanna Mislap and Jacob Hermann; front row: Melanie Herrmann (or Irene Tiring), Conrad Tiring, Emilie Kohnberger and Solomon Kohnberger

Studio portrait of Mary (Miriam) Judey Portraits Women

Born Riga 1908, married to the chemist Ernst Mangold. They escaped the Nazis, hid in France and emigrated to the US in 1948

Mary (Miriam) Mangold nee Judey; Nice Portraits Women

Born Riga 1908, married to the chemist Ernst Mangold. They escaped the Nazis, hid in France and emigrated to the US in 1948

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 x 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-kappaB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

Six unidentified, youngest members of a traditional Küfer guild posing in front of their wine barrels holding the tools of their trade and glasses of wine; Bad Dürkheim Portraits Men

Handwritten description on verso addressed to Herr u. Frau Ernst Weill

Portrait of Isaac Abraham Bürger and Ella Bürger nee Cahn.

Isaac Abraham Bürger, 1791-1864; Ella Bürger nee Cahn, 1793-1879; Parents of Samuel Isaac Bürger, 1818-1885

Paula Stern nee Rosenbaum and Maier Stern standing outdoors in a field Portraits Couples

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Photo button portrait of unidentified couple, possibly cattle dealer Julius Herzberg and his wife Olga Herzberg née Eckermann Portraits Couples

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Portrait of Ilse Bergen on her first day of school holding the candy bag traditional for the occasion (Schultuete) Portraits Children

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Eva Herzberg later Stern (left) with two unidentified young women Portraits Groups Women

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Signed portrait of Eva Herzberg later Stern Portraits Groups Women

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Hirsch, Paul Portraits Men

Dedication to Paul by Eugen Ernst