Genome - wide association study identifies novel breast cancer susceptibility loci

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r² > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10^-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

Byron Bay hysteria

"This time lapse video work of De Bruyn's evidences the bold rythmic structures found in his nahd-painted 16 mm film work. A prolific fimmaler, de Bruyn is a master of his craft and shows in this work that that mastery knows no bounds in this format."  Fractured Light exhibition catalogue

Delivering sustainability through the adaptive reuse of commercial buildings : the Melbourne CBD challenge

The City of Melbourne is aiming to be carbon neutral by 2020 (Arup 2008) and have set a target of adapting twelve hundred commercial buildings to incorporate sustainability initiatives to reduce greenhouse gas emissions from the sector (AECOM 2008). In order to meet this target the City of Melbourne is taking a proactive approach to establish strategies to deliver sustainability in the built environment within the 2020 timeframe. With regards to upgrading and building maintenance 71% of investment is used for such works (Department of the Environment 2008) and the total Australian property stock was worth over $6 trillion in June 2008. Given that building services in commercial buildings typically lasts between 20-30 years and the average age of the stock is 31 years – it appears that many properties are due for adaptation and there is major opportunity for adaptation that alleviates the impact of global warming and climate change.

Uncertainty surfaces such as; how much adaptation of existing stock is typically undertaken? And is the target of 1200 adaptations before 2020 achievable? Furthermore how could the City identify which buildings are most probable to be adapted prior to 2020? This paper details the configuration of a database of Melbourne buildings populated with data about physical, social, economic legislative and environmental attributes. There is a discussion about how the database will be used to determine; how much adaptive reuse has been undertaken historically; if any triggers to adaptation can be identified; and whether any relationships between adaptation physical, social, economic, legislative and environmental attributes and adaptation exist. The relevance of this research is obvious to all policy makers where adaptation of existing commercial buildings is perceived a as key component of delivering sustainability.

Breeding ecology and bias in offspring sex ratio in little grassbirds (Megalurus gramineus)

Little grassbirds (Megalurus gramineus) are small, sexually monomorphic passerines that live in reed beds, lignum swamps and salt marshes in southern Australia. The breeding biology and patterns of sex allocation of the little grassbird were investigated over a single breeding season. Our observations of this species in the Edithvale Wetland Reserve revealed a highly male-biased population sex ratio, with some breeding territories containing several additional males. Nevertheless, there was little compelling evidence that little grassbirds breed cooperatively. The growth rates of male and female nestlings were similar and, as predicted by theory, there was no overall primary sex ratio bias. However, the primary sex ratio was female-biased early in the breeding season and became increasingly male-biased later in the breeding season.

Are individual differences in temperament of relevance to Gibson's theory of affordances?

The ambitious scope, complexity, and difficulty of Gibson’s project in proposing the theory of affordances are captured nicely by the words of Gibson’s biographer, Ed Reed:
“Gibson was convinced that the theory of affordances, in
conjunction with the concepts of information, persistence, and
change, would enable him to transcend the ancient debate between
subjectivity and objectivity and to resolve the mind-body problem. …
[H]e was offering a new approach to problems of psychology, one
that he believed would not sink in the morass that have engulfed
previous psychologies.” (Reed, 1988, p. 280).
These characteristics of the theory of affordances are further evidenced in the debates about the nature of affordances presented in the suite of papers in Ecological Psychology, Volume 12(1). In this paper we propose an elaboration of the notion of affordance by suggesting that those persisting individual differences in behaviour described as temperamental differences (e.g., differences on a dimension of temperament anchored at one end by behaviour described as ‘outgoingness’ and at the other by behaviour described as ‘avoidance’) can be integrated into the theory of affordances. We argue that such integration is consistent with Gibson’s project as reflected in Reed’s words, and as part of our argument, draw parallels between the integration of temperament with the theory of affordances and the way in which individual differences in body dimensions are incorporated in the theory. We also outline some empirical tests of our proposition.

Location, perception and dissolution of form 1991-1993

The thesis covers a series of two and three-dimensional installations created in the investigation of both metaphorical and literal perceptions of form. The journey leads from the idea of painted-related dissolution of form in the early works, to the translation from three-dimensional to two-dimensional installations, and lastly, to experimentation with sound works where non-physical form is explored.

Spectral bequest

The exhibition held 15 paintings and covered over a year of work investigating the relationship of tonal interactions in a large body of work. This modulates suite of paintings comprised many enigmatic, mystical images, beautifully painted in a classical style. This is a solo exhibition of a series of metaphysical paintings, exhibited for the first time at a leading gallery in Brisbane.

Residential auction clearance rates – what do they really mean?

The residential market in Melbourne is often referred to as the ‘auction capital of the world’ with approximately 30-35% of housing transfers undertaken via the auction process, most of which are conducted on the weekend and then reported in the media the following day. The most quoted measurement of auction success is via the clearance rate which simply indicates the proportion of signed contracts of sale within the auction process. At the same time the clearance rate can have a relatively large variance where the residential market can traditionally range from very good (i.e. a high clearance rate) to very poor (i.e. a low clearance rate). The subsequent effect on the market can directly increase or decrease demand, predominantly based only on this single measure of the perceived level of auction clearance rates only.

This paper examines the concept of the auction clearance rates and the heavy reliance on the only one measure of success (i.e. the clearance rates), regardless of other variables. The emphasis is placed on the auction clearance rate as one measure of demand in the housing market but within the context of the definition of market value i.e. willing buyer-willing seller. This is supported by a discussion about other variables including the asking price, the auction process itself, marketing considerations and seasonal adjustments. The findings provide an insight into how to correctly interpret the auction clearance rate in the context of the overall supply-demand interactions. Whilst the auction process is clearly an integral part of the residential transfer process it is essential that the auction clearance rate is used with caution and also in conjunction with other variables.

Visionnaire 2010

Visionnaire 2010 : A screening of 15 postgraduate and masters films.

Two hundred and two - Daniella Said, Adam Green, Phoebe Beasley, Juntra Santitarangkun, Olexander Barnes & Rhett Ortlipp.
Gone to see - Sean Rafter.
Hippocratic oath - Nathan Primer, Daniel Merei, Melina Flood, Michael Dearnley, Mathew Karanicolas & Nicholas White.
The other voices - Tania Raouf.
Standover - Nicholas Hancock, Ryan Thomas, David Hurley, Nicholas Weller, Mitch McTaggart & Djorvan Caro.
Sisters - Kailai Gu.
Escape - Jonathan Burton, Simon Todd, Todd Johnson, Amanda Klimos, James Murphy, Ola Gytri & Max Reed.
Welcome to the Anderson's - Maneesha Jacob.
Hannah - Jodi Deutrom, Ardimas Andi, Ben Engeset, Kim Han Law, Steffen Hagen & Timotius.
Hour3 - Akanksha Shakya.
3-25-6 - Syamsul Azhar, Ethan Bottomley, Tiffany Dalton, Kane Gloury, Alexandra Latimer & Lene Moerch.
Seher and others - Bircan Eral.
Edward Barsky - Breidi Boyle, Bree Mansell, Simon DeNatris & Murphy McLachlan.
Detecting Calvin - Kara Tyson, Aimee Linossier, Jessica Ruffino, Seamus Parkinson, Dean Sacco & Simon Holt.
Double date - Adriana Bizzarri, Matthew Smolen, Effie Telianidis, Oliver Kerr, Lucy Ramshaw & Luisa Tascone.