[Illustrations de Le Chevalier délibéré.] / [Non identifié] ; Olivier de La Marche, aut. du texte

Comprend : [pl.1 :] Cy sarme monte et embastonne lacteur pour entrer en sa queste. [Cote : microfilm m 2045/R 52788] ; [pl.2 :] Cy se combatent lacteur et messire hutin et reliques de iennese les depart. [Cote : microfilm m 2045/R 52788] ; [pl.3 :] Comment lermite heberga lacteur et des devises quilz orent ensamble. [Cote : microfilm m 2045/R 52788] ; [pl.4 :] Comment lermite dit a lacteur que lon lappelle Entendement et des devises quilz eurent ensamble. [Cote : microfilm m 2045/R 52788] ; [pl.5 :] Comment lermite Entendement monstre les reliques a lacteur et lui devise des euvres de messze Accident et de son pouoir. [Cote : microfilm m 2045/R 52788] ; [pl.6 :] Cy commence la seconde partie de ce livre Et devise côment Entendement donna au partir a lacteur la lance de Regime. [Cote : microfilm m 2045/R 52788] ; [pl.7 :] Cy le combat lacteur a lencontre deaige. Et côment lacteur le rendit prisonnier. [Cote : microfilm m 2045/R 52788] ; [pl.8 :] Côment lacteur sest fourvoie et est venu dedât le palais damours ou belle vouloit quil entrast mais souvenir len a destourné et de ses aventures. [Cote : microfilm m 2045/R 52788] ; [pl.9 :] Cy monstre fresche memoire a lacteur les sepultures des anciens trespassez et par les escriptures voit ceulx qui ont este desconfiz par debile ou par accident. Et commence la tierce partie de ce livre. [Cote : microfilm m 2045/R 52788] ; [pl.10 :] Cy devise la bataille faitte entre mesize debile et le duc Phelippe de bourgongne. Et commence la iiii partie de ce livre. [Cote : microfilm m 2045/R 52788] ; [pl.11 :] Comment le duc Charle de bourg. combatyt Accident. [Cote : microfilm m 2045/R 52788] ; [pl.12 :] Cômêt accidêt combatit la duchesse daustrice et elle vamcue lacteur se noult pnter pour faire son devoir et cômêt atropos lêuoya contremâd par respit son herault. [Cote : microfilm m 2045/R 52788] ; [pl.13 :] Comment fresche memoire ramaine lacteur en sa maison. Et lui deuvise en chemin de ses nouvelles. [Cote : microfilm m 2045/R 52788] ; [pl.14 :] Cômêt Entêdemêt êseigne lacteur a se côduire et faire ses armes. Et cômêt il se doit armer et parer. Et comêce la V et derremiere ptie de ce livre. [Cote : microfilm m 2045/R 52788] ; [pl.15 : trois crânes. Un ange tient deux écussons avec les armoiries de la ville de Schiedam et celles de Hollande.] [Cote : microfilm m 2045/R 52788]

Genetics of normal and pathological sleep in humans.

The complexity of sleep-wake regulation, in addition to the many environmental influences, includes genetic predisposing factors, which begin to be discovered. Most of the current progress in the study of sleep genetics comes from animal models (dogs, mice, and drosophila). Multiple approaches using both animal models and different genetic techniques are needed to follow the segregation and ultimately to identify 'sleep genes' and molecular bases of sleep disorders. Recent progress in molecular genetics and the development of detailed human genome map have already led to the identification of genetic factors in several complex disorders. Only a few genes are known for which a mutation causes a sleep disorder. However, single gene disorders are rare and most common disorders are complex in terms of their genetic susceptibility, environmental factors, gene-gene, and gene-environment interactions. We review here the current progress in the genetics of normal and pathological sleep and suggest a few future perspectives.

Enhancing clinically-relevant shoulder function assessment using only essential movements.

Kinematic functional evaluation with body-worn sensors provides discriminative and responsive scores after shoulder surgery, but the optimal movements' combination has not yet been scientifically investigated. The aim of this study was the development of a simplified shoulder function kinematic score including only essential movements. The P Score, a seven-movement kinematic score developed on 31 healthy participants and 35 patients before surgery and at 3, 6 and 12 months after shoulder surgery, served as a reference.Principal component analysis and multiple regression were used to create simplified scoring models. The candidate models were compared to the reference score. ROC curve for shoulder pathology detection and correlations with clinical questionnaires were calculated.The B-B Score (hand to the Back and hand upwards as to change a Bulb) showed no difference to the P Score in time*score interaction (P > .05) and its relation with the reference score was highly linear (R(2) > .97). Absolute value of correlations with clinical questionnaires ranged from 0.51 to 0.77. Sensitivity was 97% and specificity 94%.The B-B and reference scores are equivalent for the measurement of group responses. The validated simplified scoring model presents practical advantages that facilitate the objective evaluation of shoulder function in clinical practice.

Substance P and calbindin D-28k-immunoreactivity in primary sensory neurons of chick embryos: differential neuronal birthdates and transient co-localization.

During the ontogenesis of dorsal root ganglia (DRG), the immunoreactivity to substance P (SP) and calbindin D-28k (CaBP) appears in chickens at embryonic day 5 (E5) and E10 respectively. To establish the birthdates of primary sensory neurons expressing SP or CaBP, chick embryos were given repetitive intra-amniotic injections of [3H]-thymidine. The neuroblasts giving rise to SP-expressing neurons were labeled up to E6 while those generating CaBP-immunoreactive neurons stopped to incorporate [3H]-thymidine before E5.5. This finding indicates that neurons exhibiting distinct phenotypes may originate from neuroblasts which arrest to proliferate at close but distinct stages of development. To determine whether SP and CaBP are co-expressed or not in DRG neurons, chick embryos at E12, E18, and chickens two weeks after hatching were perfused and fixed to detect simultaneously SP- and CaBP-immunoreactivity in DRG sections. The results showed that SP and CaBP were transiently co-expressed by a subset of neurons at E12. Later, however, the SP-immunoreactivity was gradually lost by these ganglion cells, so that the SP- and CaBP-immunoreaction defined two distinct neuronal subpopulations after hatching. In conclusion, most CaBP-immunoreactive DRG cells derive from a subset of neurons in which SP and CaBP are transiently co-localized.

[Illustrations de Oeuvres] / Chéron, dess. ; Vertue, dess. Van der Gucht, C. du Bosc et P. Fourdrinier, grav. ; Jean Racine, aut. du texte

Comprend : [Tome I. Bandeau à la Dédicace : lion et licorne entourant les armoiries et la devise du Duc de Glocester.] Honi soit qui mal y pense. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. folio B : la Thébaïde ou les frères ennemis. Tragédie.] Thébaïde. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. du titre de la tragédie Alexandre le grand :] Alexandre. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. du titre de la tragédie Andromaque :] Andromaque. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. du titre de la tragédie Britannicus :] Britannicus. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. du titre de la tragédie Berenice :] Berenice. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome I. Pl. en reg. du titre de la comédie Les Plaideurs :] Les Plaideurs. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Frontispice :] [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Bajazet :] Bajazet. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Mithridate :] Mithridate. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Iphigénie :] Iphigénie. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Phèdre :] Phèdre. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Esther :] Esther. [Cote : Yf 404-405/Microfilm R 122414] ; [Tome II. Pl. en reg. du titre de la tragédie Athalie :] Athalie. [Cote : Yf 404-405/Microfilm R 122414]

Assessment of bioaerosols and inhalable dust exposure in Swiss sawmills

An assessment of wood workers' exposure to airborne cultivable bacteria, fungi, inhalable endotoxins and inhalable organic dust was performed at 12 sawmills that process mainly coniferous wood species. In each plant, samples were collected at four or five different work sites (debarking, sawing, sorting, planing and sawing cockpit) and the efficiency of sampling devices (impinger or filter) for determining endotoxins levels was evaluated. Results show that fungi are present in very high concentrations (up to 35 000 CFU m(-3)) in all sawmills. We also find that there are more bioaerosols at the sorting work site (mean +/- SD: 7723 +/- 9919 CFU m(-3) for total bacteria, 614 +/- 902 CFU m(-3) for Gram-negative, 19 438 +/- 14 246 CFU m(-3) for fungi, 7.0 +/- 9.0 EU m(-3) for endotoxin and 2.9 +/- 4.8 g m(-3) for dust) than at the sawing station (mean +/- SD: 1938 +/- 2478 CFU m(-3) for total bacteria, 141 +/- 206 CFU m(-3) for Gram-negative, 12 207 +/- 10 008 CFU m(-3) for fungi, 2.1 +/- 1.9 EU m(-3) for endotoxin and 0.75 +/- 0.49 mg m(-3) for dust). At the same time, the species composition and concentration of airborne Gram-negative bacteria were studied. Penicillinium sp. were the predominant fungi, while Bacillus sp. and the Pseudomonadacea family were the predominant Gram-positive and Gram-negative bacteria encountered, respectively. [Authors]

[Illustrations de Le Chevalier délibéré] / [Non identifié] ; Olivier de La Marche, aut. du texte

Comprend : [Fig. à la Page de titre : le Chevalier Délibéré et armoiries.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. folio aiii : le Chevalier Délibéré participe à joute sur son cheval nommé Vouloir. ] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : le Chevalier Délibéré et un hermite. ] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. au folio bii : l'hermite présente des reliques.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : le Chevalier Délibéré et son vainqueur.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. folio Ci : le Chevalier Délibéré devant le château d'Amour qui l'enjoint à rentrer. Il en est détourné par Souvenir.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : Frâîche Mémoire montre des tombes au Chevalier Délibéré.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. folio Ei : le duc Philippe de Bourgogne et Débile.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : le duc Philippe de Bourgogne combat messire Accident.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : Accident et la duchesse d'Autriche.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. en reg. folio Fii : Fraîche Mémoire ramène le Chevalier Délibéré chez lui.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : Entendement enseigne le maniement des armes au Chevalier Délibéré.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. : joute de chevaliers.] [Cote : Res Ye 249/Microfilm R 33639] ; [Fig. au verso du dernier folio : marque typographique de Jean Trepperel avec armoiries et devise.] [Cote : Res Ye 249/Microfilm R 33639]

Potentiation of polarized intestinal Caco-2 cell responsiveness to probiotics complexed with secretory IgA.

The precise mechanisms underlying the interaction between intestinal bacteria and the host epithelium lead to multiple consequences that remain poorly understood at the molecular level. Deciphering such events can provide valuable information as to the mode of action of commensal and probiotic microorganisms in the gastrointestinal environment. Potential roles of such microorganisms along the privileged target represented by the mucosal immune system include maturation prior, during and after weaning, and the reduction of inflammatory reactions in pathogenic conditions. Using human intestinal epithelial Caco-2 cell grown as polarized monolayers, we found that association of a Lactobacillus or a Bifidobacterium with nonspecific secretory IgA (SIgA) enhanced probiotic adhesion by a factor of 3.4-fold or more. Bacteria alone or in complex with SIgA reinforced transepithelial electrical resistance, a phenomenon coupled with increased phosphorylation of tight junction proteins zonula occludens-1 and occludin. In contrast, association with SIgA resulted in both enhanced level of nuclear translocation of NF-κB and production of epithelial polymeric Ig receptor as compared with bacteria alone. Moreover, thymic stromal lymphopoietin production was increased upon exposure to bacteria and further enhanced with SIgA-based complexes, whereas the level of pro-inflammatory epithelial cell mediators remained unaffected. Interestingly, SIgA-mediated potentiation of the Caco-2 cell responsiveness to the two probiotics tested involved Fab-independent interaction with the bacteria. These findings add to the multiple functions of SIgA and underscore a novel role of the antibody in interaction with intestinal bacteria.

Innervation of putative rapidly adapting mechanoreceptors by calbindin- and calretinin-immunoreactive primary sensory neurons in the rat.

Calbindin and calretinin are two homologous calcium-binding proteins that are expressed by subpopulations of primary sensory neurons. In the present work, we have studied the distribution of the neurons expressing calbindin and calretinin in dorsal root ganglia of the rat and their peripheral projections. Calbindin and calretinin immunoreactivities were expressed by subpopulations of large- and small-sized primary sensory neurons and colocalized in a majority of large-sized ones. The axons emerging from calbindin- or calretinin-immunoreactive neurons innervated muscle spindles, Pacini corpuscles and subepidermal lamellar corpuscles in the glabrous skin, formed palisades of lanceolate endings around hairs and vibrissae, and gave rise to intraepidermal nerve endings in the digital skin. Since most of these afferents are considered as rapidly adapting mechanoreceptors, it is concluded that calbindin- or calretinin-expressing neurons innervate particular mechanoreceptors that display physiological characteristics of rapid adaptation to stimuli.