Circulating microRNAs as biomarkers for detection of autologous blood transfusion.

MicroRNAs (miRNAs) are small non-coding RNAs that regulate various biological processes. Cell-free miRNAs measured in blood plasma have emerged as specific and sensitive markers of physiological processes and disease. In this study, we investigated whether circulating miRNAs can serve as biomarkers for the detection of autologous blood transfusion, a major doping technique that is still undetectable. Plasma miRNA levels were analyzed using high-throughput quantitative real-time PCR. Plasma samples were obtained before and at several time points after autologous blood transfusion (blood bag storage time 42 days) in 10 healthy subjects and 10 controls without transfusion. Other serum markers of erythropoiesis were determined in the same samples. Our results revealed a distinct change in the pattern of circulating miRNAs. Ten miRNAs were upregulated in transfusion samples compared with control samples. Among these, miR-30b, miR-30c, and miR-26b increased significantly and showed a 3.9-, 4.0-, and 3.0-fold change, respectively. The origin of these miRNAs was related to pulmonary and liver tissues. Erythropoietin (EPO) concentration decreased after blood reinfusion. A combination of miRNAs and EPO measurement in a mathematical model enhanced the efficiency of autologous transfusion detection through miRNA analysis. Therefore, our results lay the foundation for the development of miRNAs as novel blood-based biomarkers to detect autologous transfusion.

La Capoeira como símbolo de los nuevos modos de representación audiovisual

Partiendo de la capacidad expresiva y reflexiva que albergan las imágenes tecnológicas para manifestar la red de implicaciones que se configuran en un sistema de representación como el que se desarrolla durante una exhibición de Capoeira, el propósito que me planteo en este trabajo consiste en abrazar el gran desafío del saber contemporáneo de educar(se) ‘en’ y ‘para’ la era planetaria, es decir, desatar un impulso de pensamiento complejo que esté animado por una tensión permanente entre la aspiración a un saber no parcelado, no dividido, no reduccionista, y el reconocimiento de lo inacabado e incompleto de todo conocimiento La aventura especulativa que se desencadena en esta investigación parte de una posición propia declarada: el análisis histórico, estético y antropológico de los fundamentos culturales que se despliegan durante una roda de Capoeira nos sirve para detectar categorías conceptuales que permiten esbozar la delimitación de un territorio metafórico donde se ilustra el carácter epistémico adscrito a la visualidad de alguno de los dispositivos y formas audiovisuales que configuran los entornos digitales comunicativos que habitamos en la actualidad

VIKI : a semiotic-based system for multilingual knowledge retrieval

Abstract Since its creation, the Internet has permeated our daily life. The web is omnipresent for communication, research and organization. This exploitation has resulted in the rapid development of the Internet. Nowadays, the Internet is the biggest container of resources. Information databases such as Wikipedia, Dmoz and the open data available on the net are a great informational potentiality for mankind. The easy and free web access is one of the major feature characterizing the Internet culture. Ten years earlier, the web was completely dominated by English. Today, the web community is no longer only English speaking but it is becoming a genuinely multilingual community. The availability of content is intertwined with the availability of logical organizations (ontologies) for which multilinguality plays a fundamental role. In this work we introduce a very high-level logical organization fully based on semiotic assumptions. We thus present the theoretical foundations as well as the ontology itself, named Linguistic Meta-Model. The most important feature of Linguistic Meta-Model is its ability to support the representation of different knowledge sources developed according to different underlying semiotic theories. This is possible because mast knowledge representation schemata, either formal or informal, can be put into the context of the so-called semiotic triangle. In order to show the main characteristics of Linguistic Meta-Model from a practical paint of view, we developed VIKI (Virtual Intelligence for Knowledge Induction). VIKI is a work-in-progress system aiming at exploiting the Linguistic Meta-Model structure for knowledge expansion. It is a modular system in which each module accomplishes a natural language processing task, from terminology extraction to knowledge retrieval. VIKI is a supporting system to Linguistic Meta-Model and its main task is to give some empirical evidence regarding the use of Linguistic Meta-Model without claiming to be thorough.

Marseille. Collection de copies et de documents originaux concernant l'histoire de Marseille. Collection Mortreuil sur Marseille vol. 12 : Corps religieux (Préfecture des Bouches du Rhône. Archives de l’église d’Arcoules, du monastère de Saint Sauveur et des Grands Trinitaires de Marseille. Actes antérieurs au XIV e siècle. A.M. 1855.)

Copie manuscrite de documents d’archives : F. 1-91. Archives de l’Eglise d’Arcoules de Marseille. F. 92-104. Augustins. F. 105-149. Archives des Dominicains (precheurs) de Marseille. F. 150-153. Abbaye de l’Huveaune, prémontrés. F. 154-178. Frères Mineurs. F. 179-180. La Major. F. 181 -184. St Carmat. F. 185-186. St Etienne des îles Ratoneau. F. 187-191. St Jacques de Corrégie. F. 192-193. St Laurent. F. 194-195. Prieuré de St Lazare. F. 196-199. St Martin F. 200-206. St Michel et St Etienne du Plan. F. 207 -379. Archives du monastère de Saint Sauveur de Marseille. F. 381-387. Sainte Claire. F. 388-391. N.D. de Syon. F. 392 459. Archives des Grands Trinitaires de Marseille.

Vitae sanctorum. Pars I. Saints du mois de janvier.

Agnes (184). - Ascla (205). - Babillus (206 v). - Balthildis regina (243 v). - Concordius (20). -Emerentiana (204). - Felix, 19 kl. febr. (105). - Firminus (101). - Fructuosus etc. (189). - Furseus (114). - Genovefa (21 v). - Hilarius (92). - Julianus et Bas. (67). - Leucus, Tyrsus et Galenicus (227). -Lutianus (62). - Macra (59). - Marcellus papa (107 v). - Martina (7 v). - Nicolaus (258 v). - Patroclus (190 v). - Paula (213 v). - Policarpus (209 v). - Quintinus (34 v). - Remigius (98). - Rigobertus (36 v). - Sabinianus (239 v). - Saturninus, Davitus etc. (142). - Sebastianus (154 v). - Speusipphus El. et Mel. (132 v). - Sulpitius (138 v). - Symeon (49 v). - Theogenius (32). - Timotheus (202 v). - Vincentius (194).

Piispa E.G. Gulin 21/10 1964

Kirje 21.10.1964

Relationship between time of day and periprocedural myocardial infarction after elective angioplasty.

Objectives: To test if the time of day significantly influences the occurrence of type 4A myocardial infarction in elective patients undergoing percutaneous coronary intervention (PCI). Background: Recent studies have suggested an influence of circadian rhythms on myocardial infarction size and mortality among patients with ST-elevation myocardial infarction. The aim of the study is to investigate whether periprocedural myocardial infarction (PMI) is influenced by the time of day in elective patients undergoing PCI. Methods: All consecutive patients undergoing elective PCI between 2007 and 2011 at our institutions with known post-interventional troponin were retrospectively included. Patients (n = 1021) were divided into two groups according to the starting time of the PCI: the morning group (n = 651) between 07:00 and 11:59, and the afternoon group (n = 370) between 12:00 and 18:59. Baseline and procedural characteristics as well as clinical outcome defined as the occurrence of PMI were compared between groups. In order to limit selection bias, all analyses were equally performed in 308 pairs using propensity score (PS) matching. Results: In the overall population, the rate of PMI was statistically lower in the morning group compared to the afternoon group (20% vs. 30%, p < 0.001). This difference remained statistically significant after PS-matching (21% vs. 29%, p = 0.03). Multivariate analysis shows that being treated in the afternoon independently increases the risk for PMI with an odds ratio of 2.0 (95%CI: 1.1-3.4; p = 0.02). Conclusions: This observational PS-matched study suggests that the timing of an elective PCI influences the rate of PMI.

Politica Farmaceutica Nacional

Com uma superfície de 4.033 Km2, Cabo Verde é um arquipélago de origem vulcânica, formado por dez ilhas e oito ilhéus. Localiza-se no Oceano Atlântico a cerca de 455 km do cabo com o mesmo nome no Senegal. Geograficamente, o arquipélago está dividido nos grupos de Barlavento e Sotavento e administrativamente em 17 concelhos (municípios). A população residente é de 434.625 habitantes, maioritariamente jovem e as mulheres representam cerca de 51,6%. A taxa de crescimento da população, dependente dos fluxos migratórios, situou-se, no decénio 1990-2000, em cerca de 2,4%. A esperança média de vida é de 71 anos, sendo 67 anos para homens e 75 para as mulheres. A Constituição da República, de 1990, abriu caminho a um sistema multipartidário, tendo o país conhecido profundas mudanças em termos de democratização, liberalização da economia, descentralização e envolvimento da sociedade civil. A economia cabo-verdiana é essencialmente de serviços, com o sector terciário a ocupar 64% na composição do PIB, enquanto o sector primário só detém 13%, apesar de empregar 47% da mão-de-obra nacional. Em 2000 o PIB per capita foi estimado em 1.354 USD.

VOLUMES RELIES du Cabinet des titres : recherches de noblesse, armoriaux, preuves, histoires généalogiques. Recherches de la noblesse dans les Généralités de Soissons et d'Alençon.

Contient : « Nobiliaire de la Généralité de Soissons » ; « Nobiliaire de la Généralité d'Alençon »

Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia.

BACKGROUND: Acute exposure to high altitude stimulates free radical formation in lowlanders, yet whether this persists during chronic exposure in healthy, well-adapted and maladapted highlanders suffering from chronic mountain sickness (CMS) remains to be established. METHODS: Oxidative-nitrosative stress (as determined by the presence of the biomarkers ascorbate radical [A •- ], via electron paramagnetic resonance spectroscopy, and nitrite [NO 2 2 ], via ozone-based chemiluminescence) was assessed in venous blood of 25 male highlanders in Bolivia living at 3,600 m with CMS (n 5 13, CMS 1 ) and without CMS (n 5 12, CMS 2 ). Twelve age- and activity-matched, healthy, male lowlanders were examined at sea level and during acute hypoxia. We also measured fl ow-mediated dilatation (FMD), arterial stiffness defined by augmentation index normalized for a heart rate of 75 beats/min (AIx-75), and carotid intima-media thickness (IMT). RESULTS: Compared with normoxic lowlanders, oxidative-nitrosative stress was moderately increased in the CMS 2 group ( P , .05), as indicated by elevated A •- (3,191 457 arbitrary units [AU] vs 2,640 445 AU) and lower NO 2 2 (206 55 nM vs 420 128 nM), whereas vascular function remained preserved. This was comparable to that observed during acute hypoxia in lowlanders in whom vascular dysfunction is typically observed. In contrast, this response was markedly exaggerated in CMS 1 group (A •- , 3,765 429 AU; NO 2 2 , 148 50 nM) compared with both the CMS 2 group and lowlanders ( P , .05). This was associated with systemic vascular dysfunction as indicated by lower ( P , .05 vs CMS 2 ) FMD (4.2% 0.7% vs 7.6% 1.7%) and increased AIx-75 (23% 8% vs 12% 7%) and carotid IMT (714 127 m M vs 588 94 m M). CONCLUSIONS: Healthy highlanders display a moderate, sustained elevation in oxidative-nitrosative stress that, unlike the equivalent increase evoked by acute hypoxia in healthy lowlanders, failed to affect vascular function. Its more marked elevation in patients with CMS may contribute to systemic vascular dysfunction.