Footnotes, January, February, March 2014, Vol. 39, no. 1-3

Monthly newsletter of State Library

Iowa Ag Review, June 1995, Vol. 1, no. 3

Iowa Ag Review is a quarterly newsletter published by the Center for Agricultural and Rural Development (CARD). This publication presents summarized results that emphasize the implications of ongoing agricultural policy analysis, analysis of the near-term agricultural situation, and discussion of agricultural policies currently under consideration.

Iowa Manure Matters: Odor and Nutrient Management, Spring 2000, Vol. 3, no. 1

Iowa Manure Matters: Odor and Nutrient Management is published by Iowa State University Extension, with funding support from the USDA Natural Resource Conservation Service.

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-throughput screen (HTS) for IDO1 inhibitors using the Prestwick Chemical Library of 1200 FDA-approved drugs and the Maybridge HitFinder Collection of 14,000 small molecules. Of the 60 hits selected for follow-up studies, 14 displayed IC50 values below 20 μM under the secondary assay conditions, and 4 showed an activity in cellular tests. In view of the high attrition rate we used both experimental and computational techniques to identify and to characterize compounds inhibiting IDO1 through unspecific inhibition mechanisms such as chemical reactivity, redox cycling, or aggregation. One specific IDO1 inhibitor scaffold, the imidazole antifungal agents, was chosen for rational structure-based lead optimization, which led to more soluble and smaller compounds with micromolar activity.

Footnotes, March 2015, Vol. 40, no.1-3

Monthly newsletter of State Library

1.° Fratris Bernardi de Virduno, ordinis Minorum, liber super totam astrologiam. — 2.° Liber de compositione et practica instrumenti astronomici, quod dicitur Turketus. — 3.° Tractatus de almanach : authore anonymo. — 4.° Theorica planetarum : authore Gerardo Carmonensi. — 5.° Liber Thebit de motu octavae sphaerae. — 6.° Ejusdem liber de iis quae indigent expositione antequam legatur almagestum Ptolemaei. — 7.° Ejusdem liber de imaginatione sphaerae et circulorum ejus diversorum. — 8.° Ejusdem liber de quantitatibus stellarum et planetarum.

Colbertinus

1.° Picatricis, Hispani, astrologia, tribus libris. — 2.° Mauritii de Gregorio, Siculi Camaratensis, ordinis Fratrum Praedicatorum, in Prosperi Aldorisii gelotoscopiam commentarii. — 3.° Anonymus de piscibus. — 4.° Rolandi physionomia in sex libros divisa.

Tellerianus

fragmenta varia simul compacta hoc ordine : — 1.° Anonymi libellus de nativitatibus. — 2.° Excerptum è libro Petri de Alliaco, Cameracensis Episcopi, de imagine mundi. — 3.° Fragmentum registri cujusdam Procuratoris nomine Guaillardi. — 4.° Fragmentum Ciceronis de optimo genere Oratorum. — 5.° Fragmentum libri cui titulus : manipulus florum, è variis sanctorum Patrum locis collectus à Magistro Thoma de Hybernia, quondam Socio de Sorbona. — 6.° Catalogus operum quorum authores feruntur Dionysius, Augustinus, Ambrosius, Hieronymus, Gregorius, Bernardus, Hilarius, Isidorus, Chrysostomus, Rabanus, Prosper, Damascenus, Anselmus, Richardus et Hugo de Sancto Victore, Alanus, Cicero, Boëtius et Seneca : finis desideratur. — Hujusce codicis pars duodecimo, pars decimo quarto saeculo videtur exarata.

nuper comparatus

1.° Hilperici tractatus de arte calculatoria : praemittitur fragmentum de calendario. — 2.° Interrogationes et responsiones de computo. — 3.° Bedae liber de sex aetatibus mundi. — 4.° Adalbaldi, Episcopi Trajectensis, opusculum super illud Boëtii : O qui perpetua mundum ratione gubernas. — 5.° Anicii Manlii Severini Boëtii libri quinque de musica. — Hujusce codicis pars duodecimo, pars decimo tertio saeculo videtur exarata.

Colbertinus

1.° Hilperici tractatus de arte calculatoria : praemittitur calendarium ad usum Cisterciensium. — 2.° Ratio Gaii Caesaris de ordine anni per duodecim menses. — 3.° Bedae opusculum de loquela digitorum. — 4.° Expositio tabulae de luna quotidiè per rationem epactarum invenienda. — 5.° Excerptum ex etymologiis Isidori, de coelo ejusque luminaribus. — 6.° Carmen de temporibus anni. — 7.° Ratio epactarum. — 8.° Anonymi expositio super tabulam Dionysii Exigui, Abbatis. — 9.° Fragmentum Macrobii de mensura terrae. — 10.° Anonymi figurata expositio duodecim signorum zodiaci. — 11.° Scholium de temporibus et aetatibus mundi. — 12.° Alcuini opusculum de vita Antichristi. — 13.° Hieronymus de quindecim signis praecedentibus diem judicii. — 14.° Beda de die judicii. — 15.° Anonymi chronicon in epitomen contractum, et à mundi creatione ad Leonis III. imperium productum. — 16.° Provincialis Romanae Ecclesiae fragmentum.

Colbertinus

1.° Tractatus de proportionibus in genere. — 2.° Tractatus de proportionibus motuum. — 3.° Fragmentum elementorum geometriae. — 4.° Tractatus de minutiis, sive de fractionibus. — 5.° Ludus rethimachiae, sive potiùs, arithmomachiae, id est, de numerorum pugna : ad calcem subjecti versiculi de eodem ludo, excerpti ex carmine de vetula, quod Ovidio tribuitur. — 6.° Anonymi tractatus de perspectiva, sive potiùs, tractatus de optica, dioptrica et catoptrica.

Mentellianus

1.° Anonymi tractatus de quadratura circuli : initium desideratur. — 2.° Sententia Adelboldi, Episcopi, ad Gerbertum, de crassitudine sphaerae. — 3.° Sententia Gerberti ad Adelboldum, Episcopum, de dissonantia arithmetica et geometrica. — 4.° Opusculum cui titulus : geometria Euclidis ; interprete Boëtio. — 5.° Fragmentum de musica.

Philiberti de la Mare

1.° Joannis de Muris tractatus de mensurandi ratione. — 2.° Anonymi opus cujus is est titulus : liber practicorum geometriae. — 3.° Aultre maniere de mesurer par le gnomon, c'est a scavoir par le dos de l'astrolabe. — 4.° Alius tractatus de geometria practica. — 5.° Traité d'arithmetique.

Colbertinus