Garten-Anlagen

Monrepos¿n puiston puutarha, kukkaistutuksia, pieni kaarisilta; taustalla Paulstein.

Das Denkmal Lafermiere's

Franz Hermann Lafermièren muistomerkki Ludvigsteinilla Monrepos'n puistossa. Muistomerkki on tyyliltään uusklassinen ja koostuu roomalaistyylisestä hautapatsaasta ja sen päällä olevasta uurnasta. Taustalla kallion päällä englantilaisen arkkitehdin Charles Heathcote Tathamin suunnittelema goottilaistyylinen linna Ludvigsburg torneineen.

Die Leukatischen Felsen

Obeliski rantakalliolla (Leukaksen kallio) Monrepos'n puistossa. Paul von Nicolay kolmen pienen poikansa kanssa nousemassa obeliskin luo. Kalliolta näkymä alas merenlahdelle, taustalla rantatemppeli ja Ludvigsburg. Obeliskin pystytti Paul von Nicolay muistomerkiksi kahdelle ranskalaiselle ruhtinaalle, August von Broglio'lle ja Carl von Broglio'lle; obeliskin suunnitteli englantilainen arkkitehti Charles Heathcote Tatham

Der Marienthurm

Mariantorni, kiinalaistyylinen huvimaja ja näkötorni Monrepos'n puistossa korkealla kukkulalla. Huvimajassa on koristellut ulkoseinät ja kiinalaistyylinen katto

Der Tempel der Frömmigkeit

Kreikkalaistyylinen rantatemppeli mereen pistävällä niemellä Monrepos'n puistossa; temppelin suunnitteli italialainen Martinelli.

Der Paulstein

Paulstein Monrepos'n puistossa; korkealla kalliolla kesämaja, näkymä alas puistoon

Das alte Schloss

Kallioinen Ludvigsteinin saari Monrepos'n puistossa, korkeimmalla kalliolla Ludvigsburg, goottilaistyylinen linna, jossa neljä tornia. Linnan suunnitteli englantilainen arkkitehti Charles Heathcote Tatham.

Der heilige Niklas

Väinämöistä esittävä patsas Monrepos'in puistossa, ympärillä kallioita ja puita; veistoksen tekijä on tanskalainen kuvanveistäjä Gotthelf Borup

Das Wohnhaus

Yleisnäkymä Monrepos'n kartanon päärakennuksesta ja sen ympäristöstä; päärakennus taustalla, vasemmalla kallion päällä obeliski.

The first SEPServer event catalogue 68-MeV solar proton events observed at 1 AU in 1996-2010

SEPServer is a three-year collaborative project funded by the seventh framework programme (FP7-SPACE) of the European Union. The objective of the project is to provide access to state-of-the-art observations and analysis tools for the scientific community on solar energetic particle (SEP) events and related electromagnetic (EM) emissions. The project will eventually lead to better understanding of the particle acceleration and transport processes at the Sun and in the inner heliosphere. These processes lead to SEP events that form one of the key elements of space weather. In this paper we present the first results from the systematic analysis work performed on the following datasets: SOHO/ERNE, SOHO/EPHIN, ACE/EPAM, Wind/WAVES and GOES X-rays. A catalogue of SEP events at 1 AU, with complete coverage over solar cycle 23, based on high-energy (~68-MeV) protons from SOHO/ERNE and electron recordings of the events by SOHO/EPHIN and ACE/EPAM are presented. A total of 115 energetic particle events have been identified and analysed using velocity dispersion analysis (VDA) for protons and time-shifting analysis (TSA) for electrons and protons in order to infer the SEP release times at the Sun. EM observations during the times of the SEP event onset have been gathered and compared to the release time estimates of particles. Data from those events that occurred during the European day-time, i.e., those that also have observations from ground-based observatories included in SEPServer, are listed and a preliminary analysis of their associations is presented. We find that VDA results for protons can be a useful tool for the analysis of proton release times, but if the derived proton path length is out of a range of 1 AU < s[3 AU, the result of the analysis may be compromised, as indicated by the anti-correlation of the derived path length and release time delay from the asso ciated X-ray flare. The average path length derived from VDA is about 1.9 times the nominal length of the spiral magnetic field line. This implies that the path length of first-arriving MeV to deka-MeV protons is affected by interplanetary scattering. TSA of near-relativistic electrons results in a release time that shows significant scatter with respect to the EM emissions but with a trend of being delayed more with increasing distance between the flare and the nominal footpoint of the Earth-connected field line.

Phenotypic and genotypic characteristics of cryopyrin-associated periodic syndrome: a series of 136 patients from the Eurofever Registry.

OBJECTIVE: To evaluate genetic, demographic and clinical features in patients with cryopyrin-associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype-phenotype correlations and predictive disease severity markers. METHODS: A web-based registry retrospectively collected data on patients with CAPS. Experts in the disease independently validated all cases. Patients carrying NLRP3 variants and germline-mutation-negative patients were included. RESULTS: 136 patients were analysed. The median age at disease onset was 9 months, and the median duration of follow-up was 15 years. Skin rash, musculoskeletal involvement and fever were the most prevalent features. Neurological involvement (including severe complications) was noted in 40% and 12% of the patients, respectively, with ophthalmological involvement in 71%, and neurosensory hearing loss in 42%. 133 patients carried a heterozygous, germline mutation, and 3 patients were mutation-negative (despite complete NLRP3 gene screening). Thirty-one different NLRP3 mutations were recorded; 7 accounted for 78% of the patients, whereas 24 rare variants were found in 27 cases. The latter were significantly associated with early disease onset, neurological complications (including severe complications) and severe musculoskeletal involvement. The T348M variant was associated with early disease onset, chronic course and hearing loss. Neurological involvement was less strongly associated with V198M, E311 K and A439 V alleles. Early onset was predictive of severe neurological complications and hearing loss. CONCLUSIONS: Patients carrying rare NLRP3 variants are at risk of severe CAPS; onset before the age of 6 months is associated with more severe neurological involvement and hearing loss. These findings may have an impact on treatment decisions.

Allegro Moderato af H.J. Müller med accomp. af en Violin

Soitinnus: piano.

Wattenliljan

Simananniemen käsikirjoituskokoelma.

Grand sonata Piano Forte and Violoncello Op 17

Sello, piano