EPI Update, February 6, 2009

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents.

Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.

Radiopuhe Stalinin kuoleman johdosta 6.3.1953

Puhe

Helsinki 23/6 -33

Kirje 23.6.1933

EPI Update, March 6, 2009

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Kniemi 6/9 -24

Kirje 6.9.1924

Angervonniemellä 6.8.1929

Kirje

Budjetti vuodelle 1937, 6 Pl Yk

Puhe

Budapestissa 10/6 -28

Kirje 10.6.1928

Maaherra Urho Kiukas 14/6 1966

Kirje 14.6.1966

Colombes, 17/2/20, France contre Pays de Galles [phase de jeu du match de rugby remporté par Galles 6 à 5] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58044