Kermit interacts with gαo, vang, and motor proteins in Drosophila planar cell polarity.

In addition to the ubiquitous apical-basal polarity, epithelial cells are often polarized within the plane of the tissue - the phenomenon known as planar cell polarity (PCP). In Drosophila, manifestations of PCP are visible in the eye, wing, and cuticle. Several components of the PCP signaling have been characterized in flies and vertebrates, including the heterotrimeric Go protein. However, Go signaling partners in PCP remain largely unknown. Using a genetic screen we uncover Kermit, previously implicated in G protein and PCP signaling, as a novel binding partner of Go. Through pull-down and genetic interaction studies, we find that Kermit interacts with Go and another PCP component Vang, known to undergo intracellular relocalization during PCP establishment. We further demonstrate that the activity of Kermit in PCP differentially relies on the motor proteins: the microtubule-based dynein and kinesin motors and the actin-based myosin VI. Our results place Kermit as a potential transducer of Go, linking Vang with motor proteins for its delivery to dedicated cellular compartments during PCP establishment.

G-1 Appeal Activity in the Public Assistance Programs, April 2007

G-1 - Appeal Activity in the Public Assistance Programs - April 2007

G-1 Appeal Activity in the Public Assistance Programs, March 2007

G-1 - Appeal Activity in the Public Assistance Programs - March 2007

G-1 Appeal Activity in the Public Assistance Programs, May 2007

G-1 - Appeal Activity in the Public Assistance Programs - May 2007

Récréations dramatiques à l'usage des écoles, patronages, pensionnats / par un ami de la jeunesse. A. M. D. G.. Le tambour nocturne. Le dissipateur. Le jeune homme à l'épreuve. Herménégilde. Les sept dormants

Comprend : Le tambour nocturne ou l'esprit frappeur : [comédie en 5 actes] - Le dissipateur : [comédie en 3 actes] - Le jeune homme à l'épreuve : [comédie en 4 actes] - Herménégilde martyr : [tragédie en 5 actes] - Les sept dormants : [comédie en 5 actes]

Le voyage de la France à S. Germain, avec ses plaintes à la Reine, contre le cardinal Mazarin. Et ses prières pour la Paix, & le retour de leurs Majestez à Paris, par L. B. E. S. D. G. M. O. D. R.

[Mazarinade. 1649]

Le voyage de la France à S. Germain, avec ses plaintes à la Reine, contre le cardinal Mazarin. Et ses prières pour la Paix, & le retour de leurs Majestez à Paris, par L. B. E. S. D. G. M. O. D. R.

[Mazarinade. 1649]

G-1 Appeal Activity in the Public Assistance Programs, June 2007

G-1 Appeal Activity in the Public Assistance Programs, June 2007