997 resultados para Gómez Pedraza,Manuel, 1789-1851
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The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized examples, with several discrete enhancers reported within its introns, vast upstream gene-free region and neighboring genes (Lmbr1 and Rnf32). To investigate the origin and evolution of this GRB, we sequenced and characterized the Hedgehog (Hh) loci from three invertebrate chordate amphioxus species, which share several early expression domains with Shh. Using phylogenetic footprinting within and between chordate lineages, and reporter assays in zebrafish probing >30 Kbp of amphioxus Hh, we report large sequence and functional divergence between both groups. In addition, we show that the linkage of Shh to Lmbr1 and Rnf32, necessary for the unique gnatostomate-specific Shh limb expression, is a vertebrate novelty occurred between the two whole-genome duplications.
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Cognitive impairment in schizophrenia and psychosis is ubiquitous and acknowledged as a core feature of clinical expression, pathophysiology, and prediction of functioning. However, assessment of cognitive functioning is excessively time-consuming in routine practice, and brief cognitive instruments specific to psychosis would be of value. Two screening tools have recently been created to address this issue, i.e., the Brief Cognitive Assessment Tool for Schizophrenia (B-CATS) and the Screen for Cognitive Impairment in Psychiatry (SCIP). The aim of this research was to examine the comparative validity of these two brief instruments in relation to a global cognitive score. 161 patients with psychosis (96 patients diagnosed with schizophrenia and 65 patients diagnosed with bipolar disorder) and 76 healthy control subjects were tested with both instruments to examine their concurrent validity relative to a more comprehensive neuropsychological assessment battery. Scores from the B-CATS and the SCIP were highly correlated in the three diagnostic groups, and both scales showed good to excellent concurrent validity relative to a Global Cognitive Composite Score (GCCS) derived from the more comprehensive examination. The SCIP-S showed better predictive value of global cognitive impairment than the B-CATS. Partial and semi-partial correlations showed slightly higher percentages of both shared and unique variance between the SCIP-S and the GCCS than between the B-CATS and the GCCS. Brief instruments for assessing cognition in schizophrenia and bipolar disorders, such as the SCIP-S and B-CATS, seem to be reliable and promising tools for use in routine clinical practice.
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Objectives: The growing interest in minimally invasive surgery, together with the possibility of fitting prostheses with immediate function, have led to the development of software capable of planning and manufacturing a surgical guide and prosthesis that can be placed upon conclusion of the implant surgery step. The present study evaluates the surgical and prosthetic complications of implant treatment with the guided surgery technique, together with patient comfort during and after treatment. Patients and methods: A retrospective observational study was made of 19 patients with partially or totally edentulous upper and/or lower maxillae, involving the placement of a total of 122 implants. All cases were planned and operated upon with the guided surgery technique. Results: A total of 122 implants were placed in 14 males and 5 females. The intraoperative surgical complications comprised a lack of primary stability, while the postoperative complications consisted of infections and a lack of implant osteointegration. Ten implants failed. The prosthetic complications in turn comprised loosening of the provisional prosthesis screws, prosthesis tooth fracture, and a lack of passive fit of the immediate prosthesis. The degree of patient satisfaction was evaluated using a verbal scale. Conclusions: Implant restoration with the guided surgery technique and immediate functional loading is a predictable procedure, provided patient selection and the surgical technique are adequate, affording lesser postoperative morbidity and increased patient satisfaction thanks to the immediate restoration of esthetics and function
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This paper describes and analyses language norms in a storytelling manual published in the Frenchspeaking part of Switzerland. In the manual, storytelling is conceived as a means of persuasion and thus it appears that an appropriate storytelling should lead to believe or to act. What exactly is "appropriateness" in this specific case? In order to examine this issue, this paper addresses three questions: how storytelling is promoted as an efficient communicative technique; which methods are used to propose and support language norms (by showing "what the storyteller should do" and by saying "how he should do so"); and which are the criteria which define an appropriate story (semantic/formal and functional criteria) and an appropriate telling of the story (communicative and linguistic criteria).
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Parece mentira que una pieza teatral firmada por Calderón de la Barca haya tardado más de tres cientos años en aparecer impresa y que sea ahora,en el 2010, cuando lo haga por primera vez. ¿A qué se debe esta falta de interés por la obra?La respuestanos la ofrecen Felipe B. Pedza Jiménez y Rafael González Cañal en el capítulo que abre el estudio preliminar de su edicion tulado«Razones de una sin razón»
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En ple procés de codificació del dret civil de Catalunya, pot semblar quelcom romàntic analitzar com es visqué al Principat un altre moviment co- dificador: el del segle XIX. És clar que aquest darrer tenia un caràcter que no s"assembla en res a l"actual, tret de la mateixa voluntat de codificar. Es va tractar aleshores d"unificar i sistematitzar el dret civil d"Espanya, en resposta a una tendència generalitzada que s"havia estès a bona part d"Europa. Es tracta, ara, de codificar el dret civil de Catalunya en exercici d"una competència legislativa constitucionalment i estatutàriament reconeguda. Malgrat aquesta diferent significació, o potser per això, sentim un agradable sentimentalisme en mirar enrere. L"objecte del nostre comentari se centra, només, en l"intent de codificació de mitjan segle XIX: en l"anomenat Projecte de Codi civil de 1851. A Catalunya, el dit Projecte va despertar reaccions apassionades, quasi totes desfavorables al text codificat i no tant pel fet de voler codificar el dret civil, sinó pel caire castellanitzant del seu contingut, que negava tota vigència als altres drets territorials. Alhora, l"anàlisi que es proposa es redueix a la regulació projectada de la llegítima. I la resposta que va merèixer des de Catalunya s"esbossà de la mà d"un jurista autoritzat de l"època: Estanislao Reynals i Rabassa. Esdevé un més entre una gran munió de personatges vuitcentistes, tots ells intel·lectuals, que apareixen aquí i allà, en el decurs d"esdeveniments literaris, acadèmics, polítics, etc., i que permeten identificar una reacció prou sentida en contra dels elements revulsius dels trets de la identitat catalana.
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1843.
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1901.
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1870 (A12).
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1864 (A6).
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1867 (A9).
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1862 (A4).
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1866 (A8).
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1869 (A11).
