Die Naturgeschichte des Thierreichs / von C.G. Giebel.

bd. 3

Handbuch der botanischen Terminologie und Systemkunde / von Gottlieb Wilhelm Bischoff.

bd. 3 pt. 2

Letter from Francis von Hammer to William Tudor,

One letter wishing Tudor safe passage to Genoa and requesting Tudor forward his letters to an address in Florence.

Erlangen, Germany, 1721 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Accurater Grundris und Gegend des Hoch-Fürstl. Brandenb. Bayreuth. neu-erbauten Stadt Christian-Erlang : samt denen Prospecten des Hoch-Fürstl. Residenz-Schloss und anderer ansehnlichen Gebäuen, wie auch der nach ihrem fatalen Brand wieder gantz aufgebauten neuen Alt-Stadt Erlang, Joh. Christoph Homann Geometrice delineavit A. 1721 ; edirt von Ioh. Bapt. Homann keiserl. Geogr. It was published by Johann Baptist Homann in 1721. Scale [ca. 1:8,200]. Covers Erlangen, Germany. Map in German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Deutsches Hauptdreiecksnetz (DHDN) 3-degree Gauss-Kruger Zone 4 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortifications, ground cover, and more. Relief shown with hachures. Includes also index and 7 views of the city.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

BACKGROUND Intravenous immunoglobulin (IVIG) proved to be an efficient anti-inflammatory treatment for a growing number of neuroinflammatory diseases and protects against the development of experimental autoimmune encephalomyelitis (EAE), a widely used animal model for multiple sclerosis (MS). METHODS The clinical efficacy of IVIG and IVIG-derived F(ab')2 fragments, generated using the streptococcal cysteine proteinase Ide-S, was evaluated in EAE induced by active immunization and by adoptive transfer of myelin-specific T cells. Frequency, phenotype, and functional characteristics of T cell subsets and myeloid cells were determined by flow cytometry. Antibody binding to microbial antigen and cytokine production by innate immune cells was assessed by ELISA. RESULTS We report that the protective effect of IVIG is lost in the adoptive transfer model of EAE and requires prophylactic administration during disease induction. IVIG-derived Fc fragments are not required for protection against EAE, since administration of F(ab')2 fragments fully recapitulated the clinical efficacy of IVIG. F(ab')2-treated mice showed a substantial decrease in splenic effector T cell expansion and cytokine production (GM-CSF, IFN-γ, IL-17A) 9 days after immunization. Inhibition of effector T cell responses was not associated with an increase in total numbers of Tregs but with decreased activation of innate myeloid cells such as neutrophils, monocytes, and dendritic cells. Therapeutically effective IVIG-derived F(ab')2 fragments inhibited adjuvant-induced innate immune cell activation as determined by IL-12/23 p40 production and recognized mycobacterial antigens contained in Freund's complete adjuvant which is required for induction of active EAE. CONCLUSIONS Our data indicate that F(ab')2-mediated neutralization of adjuvant contributes to the therapeutic efficacy of anti-inflammatory IgG. These findings might partly explain the discrepancy of IVIG efficacy in EAE and MS.

Über den Einfluss von Palmitin- und Linolsäure auf die Entstehung von Lipidakkumulaten unter der Bedingung von Hyperglykämie und Hyperinsulinämie und den protektiven Wirkungen eines ethanolischen Extraktes aus Gynostemma pentaphyllum in primären Hepatozytenkulturen

Universität Magdeburg, Dissertation, 2015

Lyra Germanica: hymns for the Sundays & chief festivals of the Christian year.

Mode of access: Internet.

Mémoires de Barthélemy, 1768-1819,

Mode of access: Internet.

Wie Carl August, Grotzherzog von Sachsen-Weimar, sich bei Berketzerungsversuchen gegen akademische Lehrer behahm.

"Aktenmässig dargestellt."

Die anthropogeographische Bedeutung der wichtigsten Sumpflandschaften von Nordwestdeutschland /

Thesis (doctoral)--Christian-Albrechts-Universität zu Kiel, 1909.