A list of buildings in Great Britain and Ireland having mural and other painted decorations,

Mode of access: Internet.

Americans by adoption; brief biographies of great citizens born in foreign lands,

Stephen Girard.--John Ericsson.--Louis Agassiz.--Carl Schurz.--Theodore Thomas.--Andrew Carnegie.--James J. Hill.--Augustus Saint-Gaudens.--Jacob A. Riis.

History of the Holy Eucharist in Great Britain.

Mode of access: Internet.

Problems of Greater Britain,

Mode of access: Internet.

The use of lead compounds in pottery, from the potter's point of view.

Published "by request of the Joint Committee of the Allied Manufacturers' Associations of Great Britain."

Report of Agricultural Commission to Europe. Observations made by American agriculturists in Great Britain, France, and Italy for the United States Department of Agriculture.

Mode of access: Internet.

Great Britain - Companies (consolidation) act, 1908. Digest of provisions in respect to the powers and duties of the Board of trade in connection with the administration of the Act, publicity of corporate affairs, and penalties. Outline of history and organization of the Board of trade.

Mode of access: Internet.

Little journeys to the homes of great business men,

--[v. 2. no. 1] Peter Cooper. [v.2. no. 2] Andrew Carnegie. [v.2. no. 3.] George Peabody. [v. 2. no. 4.] A.T. Stewart. [v. 2. no. 5.] H.H. Rogers. [v. 2. no. 6.] James J. Hill.

Veitch's manual of the coniferae : containing a general review of the order, a synopsis of the species cultivated in Great Britain, their botanical history, economic properties, place and use in arboriculture, etc. /

Includes index.

The Journal of mental science.

Title from caption.

The colonization of rural Britain; a complete scheme for the regeneration of British rural life,

Paged continuously.

Shorthorn breeders' guide, with a short history of the breed and its capabilities, accounts of shows and sales and articles of general interest to Shorthorn breeders.

Mode of access: Internet.

Arbitration of outstanding pecuniary claims between Great Britain and the United States of America. The Frederick Gerring, jr.

Mode of access: Internet.

Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity

Immunohistochemical analysis of E-cadherin has changed the way lobular neoplasia is perceived. It has helped to classify difficult cases of carcinoma in situ with indeterminate features and led to the identification of new variants of lobular carcinoma. Pleomorphic lobular carcinoma (PLC) and pleomorphic lobular carcinoma in situ (PLCIS), recently described variants of invasive and in situ classic lobular carcinoma, are reported to be associated with more aggressive clinical behaviour. Although PLC/PLCIS show morphological features of classic lobular neoplasia and lack E-cadherin expression, it is still unclear whether these lesions evolve through the same genetic pathway as lobular carcinomas or are high-grade ductal neoplasms that have lost E-cadherin. Here we have analysed a case of extensive PLCIS and invasive PLC associated with areas of E-cadherin-negative carcinoma in situ with indeterminate features, using immunohistochemistry, chromogenic in situ hybridization, high-resolution comparative genomic hybridization (CGH) and array-based CGH. We observed that all lesions lacked E-cadherin and beta-catenin and showed gain of 1q and loss of 16q, features that are typical of lobular carcinomas but are not seen in high-grade ductal lesions. In addition, amplifications of c-myc and HER2 were detected in the pleomorphic components, which may account for the high-grade features in this case and the reported aggressive clinical behaviour of these lesions. Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Molecular evolution of breast cancer

Molecular analysis of invasive breast cancer and its precursors has furthered our understanding of breast cancer progression. In the past few years, new multi-step pathways of breast cancer progression have been delineated through genotypic-phenotypic correlations. Nuclear grade, more than any other pathological feature, is strongly associated with the number and pattern of molecular genetic abnormalities in breast cancer cells. Thus, there are two distinct major pathways to the evolution of low- and high-grade invasive carcinomas: whilst the former consistently show oestrogen receptor (ER) and progesterone receptor (PgR) positivity and 16q loss, the latter are usually ER/PgR-negative and show Her-2 over-expression/amplification and complex karyotypes. The boundaries between the evolutionary pathways of well-differentiated/low-grade ductal and lobular carcinomas have been blurred, with changes in E-cadherin expression being one of the few distinguishing features between the two. In addition, lesions long thought to be precursors of breast carcinomas, such as hyperplasia of usual type, are currently considered mere risk indicators, whilst columnar cell lesions are now implicated as non-obligate precursors of atypical ductal hyperplasia (ADH) and well-differentiated ductal carcinoma in situ (DCIS). However, only through the combination of comprehensive morphological analysis and cutting-edge molecular tools can this knowledge be translated into clinical practice and patient management. Copyright (C) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.