Panamá: educación reproductiva y paternidad responsable

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Políticas para la innovación en las pequeñas y medianas empresas en América Latina

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Multiple minima hypersurfaces procedures for biomimetic ligands screening

In this work the interaction of the pesticide carbaryl with two groups of biomimetic ligands, peptides and MIPs was screened by multiple minima hypersurfaces (MMH) procedures, through the AM1 semiempirical method. Data related to the properties of the molecular association of the complex biomimetic ligand-pesticide were obtained and compared with another molecular modeling algorithm named Leapfrog, as included in the Sybyl software package, and experimental results from the literature, remarking good correlation between them. All important MMH program parameters (cells number, box size, conformers) were studied and optimized with the aim of getting the minimum computation time without losing the correlation with experimental data. The data demonstrated that MMH approach can be used as a fast biomimetic ligand screening tool for MIPs. In the case of peptides the computation time was not comparable with the molecular dynamics methods conventionally used for this approach. © 2011 Springer Science+Business Media B.V.

Innovación y territorio. Ideas para nuevas actuaciones de las agencias de desarrollo

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AC-DC three-phase multipulse converter with boost DC-DC stage and constant hysteresis control

This work proposes a new three-phase multipulse rectifier based on the delta autotransformer connection with DC-DC Boost stages and constant hysteresis control which has the objective of providing a reliable DC bus for on-board applications, electric motor drives and similars, always considering power quality issues. Thus, the proposal presents 0.99 power factor, 6% harmonic distortions in the currents from the mains and enhanced magnetic core utilization, which results in low weight and volume for the overall converter. The proposed control technique uses the simple constant hysteresis concept, thus leading to a low-cost but effective and reliable strategy. © 2011 IEEE.

β-lactam antibiotics epitope mapping with STD NMR spectroscopy: A study of drug-human serum albumin interaction

Molecular recognition events are key issues in many biological processes. STD NMR (saturation transfer difference nuclear magnetic resonance spectroscopy) is one of the techniques used to understand such biological interactions. Herein, we have investigated the interactions of four β-lactam antibiotics belonging to two classes (cephalosporins and penicillins) with human serum albumin (HSA) by 1H STD NMR revealing that the interaction between the aromatic moiety and HSA is responsible for the binding efficiency. Thus, the structural differences from the five to six-membered thio ring in penicillins and cephalosporins do not seem to influence antibiotic-albumin interactions. © 2012 Sociedade Brasileira de Química.

Población y cultura: el caso de los pueblos indígenas en Bolivia

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Morfologia do seio coronário em fetos de bovinos azebuados

The coronary sinusin fetuses ofzebu-crossedbovinesis studiedbyvasculardissectionsand radiographs. There aretwopredominant patterns offormation of thecoronary sinus: bydirect continuation of theleft azygos vein, from thegreat cardiac vein, and by theunion of thegreat cardiac veinwith theleft azygos vein. The first patternappeared in17animals,while thesecondpatternformation of thecoronary sinuswas found in13animals. Regarding sex there was nodifference between thepatterns shown.The main tributariesof the coronaryveinincattleare representedby the followingvessels: great cardiac vein, middle cardiac vein, veins of the faceof theleft ventricle andatrium, obliqueveinof left atrium.The great cardiac veinisseen asadirect continuation of theinterventricular veinparaconal. From these results, it appears thatthe standardvenousfetalbovineheartis predominantlyconfluentthe coronary sinus. Onlyasmall number ofvesselsare directlyconfluentto theright atrium ofbovine heart.

Correspondence between the self-dual model and the topologically massive electrodynamics: A new view

Following the study of the Topologically Massive Theories under the Hamilton-Jacobi, we now analyze the constraint structure of the Self-Dual model as well as its correspondence with the Topologically Massive Electrodynamics. © 2013 American Institute of Physics.

Avaliação de sintomas neuropsiquiátricos na demência: Para melhorar a precisão

The issue of this article concerned the discussion about tools frequently used tools for assessing neuropsychiatric symptoms of patients with dementia, particularly Alzheimer's disease. The aims were to discuss the main tools for evaluating behavioral disturbances, and particularly the accuracy of the Neuropsychiatric Inventory - Clinician Rating Scale (NPI-C). The clinical approach to and diagnosis of neuropsychiatric syndromes in dementia require suitable accuracy. Advances in the recognition and early accurate diagnosis of psychopathological symptoms help guide appropriate pharmacological and non-pharmacological interventions. In addition, recommended standardized and validated measurements contribute to both scientific research and clinical practice. Emotional distress, caregiver burden, and cognitive impairment often experienced by elderly caregivers, may affect the quality of caregiver reports. The clinician rating approach helps attenuate these misinterpretations. In this scenario, the NPI-C is a promising and versatile tool for assessing neuropsychiatric syndromes in dementia, offering good accuracy and high reliability, mainly based on the diagnostic impression of the clinician. This tool can provide both strategies: a comprehensive assessment of neuropsychiatric symptoms in dementia or the investigation of specific psychopathological syndromes such as agitation, depression, anxiety, apathy, sleep disorders, and aberrant motor disorders, among others.

Analysis of artisanal fisheries in two reservoirs of the upper Paraná River basin (Southeastern Brazil)

We compared the artisanal fisheries, in terms of catch strategies, productivity, and gross per capita income, at two reservoirs: The Barra Bonita (an eutrophic reservoir with some introduced species), and the Jurumirim (an oligotrophic reservoir, with no introduced species). Published data and structured interviews with fishers were used to evaluate fishing activity, fish biomass, and the financial performance of the fisheries. In the Barra Bonita Reservoir we analysed data from 745 fishing trips, from which 86,691.9 kg of fish were landed, with a mean CPUE of 62.4 kg/fisher-1 day-1. The main type of fish caught was tilapia (71,513.5 kg; CPUE of 51.5 kg/fisher-1 day-1), which constituted 82.5% of the biomass caught. In the Jurumirim Reservoir, we analysed data from 2,401 fishing trips, from which 25,093.6 kg of fish were landed, with a mean CPUE of 10.4 kg/fisher-1 day-1. The main type of fish caught was traíra (6,158.6 kg; CPUE of 2.6 kg/fisher-1 day-1), which constituted 24.5% of the biomass caught. Ordination analysis (PCA) indicated that there was a difference in composition between the fishing reservoirs and ANCOVA showed that there was a significant difference in fish production between the reservoirs. A Student's t-test showed that fishers in the Barra Bonita Reservoir had a significantly higher gross per capita income than those from the Jurumirim Reservoir. Although the Barra Bonita Reservoir has a higher fish production and the fishers earn a higher gross per capita income, we recommend the Jurumirim Reservoir as a model for artisanal fishery management because fishing activity in this reservoir is viable in the long term and such a model would promote conservation and sustainability. This contrasts with the Barra Bonita Reservoir, in which the fishery is not viable in the long term, due to environmental problems caused by artificial eutrophication and the introduction of alien species. It is also noted that in many countries, management of fisheries based on exotic species has not been viable in the long term. © 2013 Sociedade Brasileira de Ictiologia.

Notas para la discusión de la Segunda Reunión de Funcionarios Responsables del Comercio Exterior de América Latina

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Utilização de macrófitas aquáticas flutuantes no tratamento de efluentes de carcinicultura

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)