158-μJ pulses from a single-transverse-mode, large-mode-area erbium-doped fiber amplifier

We report the amplification of 10-100-pJ semiconductor diode pulses to an energy of 158 μJ and peak powers >100 kW in a multistage fiber amplifier chain based on a single-mode, large-mode-area erbium-doped amplifier design. To our knowledge these results represent the highest single-mode pulse energy extracted from any doped-fiber system. © 1997 Optical Society of America.

Results of the Austrian-Ceylonese hydrobiological mission 1970 of the 1st Zoological Institute of the University of Vienna (Austria) and the Department of Zoology of the University of Ceylon, Vidyalankara Campus, Kelaniya (Sri Lanka). [Pt. 15.] Collection of fishes (Osteichthyes)

A total of 378 specimens from 25 collecting localities belonging to 31 different species of fish collected mainly from the rivers of the hilly and mountain regions of the south-western and southern Ceylon have been identified and recorded. Ecological data and water analyses of these collecting localities are given.

The fisheries resources of Lake Nakivali

Lake Nakivali is one of the four small lakes that form what is known as the koki lake sysyem. It is 14km long,6km wide.26km sqaured in area and has maximum depth of 3.5m at high water level. The lake is located in lake-swamp complex with river Rwizi as the principle inflow, and a number of peripheral lakes among which are four major ones,i.e Lake Nakivali, Mburo, Kachira and Kijanebalola. Lake Nakivali is a controlled lake with four official landing sites, namely: Kikusi, Kahirimbi, Kashojwa and Rukinga. The latter three are located within a Refugee settlement whereas Kikusi is outside. The Nakivali Refugee settlement initially established for Rwandese of Tutsi origin in 1963, now has at least seven nationalities which include people from Rwanda, Democratic Republic of Congo, Somalia, Sudan, Ethiopia, Kenya and Eritrea. By the end of 2006, the lake’s hinterland of about 378 km squared contained 43,448 people of whom 22,448 were refugees. This large population has had stressful impacts on both land and lake resources to the extent that now there is an apparent overfishing on the lake.

MULTIPLE GENOTYPES OF MITOCHONDRIAL-DNA WITHIN A HORSE POPULATION FROM A SMALL REGION IN YUNNAN PROVINCE OF CHINA

mtDNA genotypes of six domestic horses (three adult short horses whose heights are under 1 m and three common domestic horses) from a small region of 15 km(2) in Malipo county of Yunnan province of China were investigated by the technique of restriction fragment length polymorphism (RFLP) with restriction endonucleases which recognize 6-bp sequences. An average of fragments for an individual was obtained. Unlike other domestic animals, this population of horses exhibits high mtDNA genetic diversity. Each of the six horses has a specific mtDNA genotype showing a pattern of multiple maternal origins, as suggested by fossil and literature records. We think the population of horses is an amazing seed-resource pool of horses and hence deserves to be paid more attention from the view of conservation genetics. However it is also remarkable that we did not find any typical mtDNA genetic markers which would discriminate between short horses and common domestic horses.

非晶状体βγ晶状体蛋白与三叶因子蛋白复合物诱导兔胸主动脉环内皮依赖的持续收缩效应

脊椎动物中,非晶状体βγ-晶状体蛋白广泛分布于各种组织,但是功能知之甚少.三叶因子在创伤修复与肿瘤发生中具有重要作用,其分子作用机制尚不清楚.非晶状体βγ晶状体蛋白与三叶因子蛋白复合物(βγ-CAT)是一个从大蹼铃蟾皮肤分泌物中分离的一类全新的蛋白复合物.研究表明,βγ-CAT能够诱导离体的兔胸主动脉产生快速而持续的收缩,结合药理学抑制剂,细胞培养,激光共聚焦显微镜和免疫荧光原位组化,从细胞和分子水平对其作用机制进行研究.结果表明:.βγ-CAT诱导兔胸主动脉产生的收缩效应为剂量依赖(2-35 nmol/L)和内皮依赖(P＜0.01).在βγ-CAT(25nmol/L)处理的主动脉环的内皮细胞层检测到肿瘤坏死因子-α的释放.同时,βγ-CAT能够诱导原代培养的兔胸主动脉内皮细胞(RAEC)快速释放肿瘤坏死因子-α,βγ-CAT(25nmol/L)分别处理5和30min,RAEC释放的肿瘤坏死因子-α的浓度分别为(34.17±5.10)pg/mL和(98.01±4.67)pg/mL(P＜0.01).表明肿瘤坏死因子-α在βγ-CAT诱导兔胸丰动脉产生的收缩效应中发挥重要作用.为进一步深入研究非晶状体βγ晶状体蛋白与三叶因子的生理功能提供了新的思路和线索.

大蹼铃蟾博玛津蛋白及其基因和在制药中的应用

本发明涉及一种大蹼铃蟾博玛津蛋白及其基因和在制药中的应用，属于生物医学领域。大蹼铃蟾博玛津蛋白是从中国两栖类动物大蹼铃蟾皮肤分泌物中分离得到的一种单链多肽，氨基酸全序列为：NH2GFPIYEIDNRPGCYVDPAERVACAGAGVTKAECKAKGCCFISARRNTIWCFKLKESADAWKCAVPMNTRVACAGAGVTPAECKGKGCCFSSYYGTV WCFKPQE-COOH)编码大蹼铃蟾博玛津蛋白的基因的cDNA由1061个核苷酸组成，编码成熟血小板活化蛋白为第67-378位核苷酸。博玛津具有诱导血小板活化、抑制胃溃疡的作用，可作为血小板聚集诱导剂和制备胃溃疡药物的应用。

一个脱毛相关基因及其应用

本发明涉及一个脱毛相关基因及其应用，属于生物技术领域。本发明确定了一无毛基因与昆明小鼠脱毛性状的相关性。该基因被定位于小鼠14号染色体，在细胞遗传图谱上的位置是14D1，在连锁图谱上的位置是39.5cM，全长约20.281KbDNA序列，转录产物(cDNA)有4017bp，含有19个外显子，从成熟mRNA的第378位(2号外显子)开始翻译，共编码1182个氨基酸残基。通过测序，该基因第2817位无义突变(C→T)是导致昆明种犀牛小鼠KIZ脱毛的遗传基础。而且，该基因在人类基因组中也非常保守，具有相似的功能。所以该基因可以用来研究人秃头症的致病机理，以及作为设计治疗丘疹性秃头症药物的靶基因。

Apoptotic cells induce immunosuppression through dendritic cells: Critical roles of IFN-gamma and nitric oxide

Apoptotic cells induce immunosuppression through unknown mechanisms. To identify the underlying molecular mediators, we examined how apoptotic cells induce immunoregulation by dendritic cells (DC). We found that administration of DC exposed to apoptotic c

Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

Bone marrow-derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we show here, the mechanism of MSC-mediated immunosuppression varies