Animal models in chronic obstructive pulmonary disease-an overview

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airway obstruction resultant from an augmented inflammatory response of the respiratory tract to noxious particles and gases. Previous reports present a number of different hypotheses about the etiology and pathophysiology of COPD. The generating mechanisms of the disease are subject of much speculation, and a series of questions and controversies among experts still remain. In this context, several experimental models have been proposed in order to broaden the knowledge on the pathophysiological characteristics of the disease, as well as the search for new therapeutic approaches for acute or chronically injured lung tissue. This review aims to present the main experimental models of COPD, more specifically emphysema, as well as to describe the main characteristics, advantages, disadvantages, possibilities of application, and potential contribution of each of these models for the knowledge on the pathophysiological aspects and to test new treatment options for obstructive lung diseases.

Random regression models using different functions to model milk flow in dairy cows

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Equações de Painlevé mistas e modelo PIII-PV simétrico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Alocação ótima de chaves de interconexão nas redes de distribuição de energia elétrica

Pós-graduação em Engenharia Elétrica - FEIS

Adsorção de antibióticos em meio aquoso utilizando diferentes adsorventes

Pós-graduação em Ciência dos Materiais - FEIS

Three-dimensional dental arch changes of patients submitted to orthodontic-surgical treatment for correction of Class II malocclusion

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Monitoramento das irregularidades ionosféricas e cintilação dos sinais GNSS: em tempo real e pós-processado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Random regression models for milk, fat and protein in Colombian Buffaloes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Superconducting properties of a parallelepiped mesoscopic superconductor: a comparative study between the 2D and 3D Ginzburg-Landau models

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Theoretical study of the stoichiometric and reduced Ce-Doped TiO2 anatase (001) surfaces

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estimating the development of the fennel aphid, Hyadaphis foeniculi (Passerini) (Hemiptera: Aphiididae), using non-linear models

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Two-dimensional models in quantum field theory: Reduction to the free-particle case

We demonstrate that the generating functionals for two-dimensional models with two real scalar fields, one interacting with an external electromagnetic field and the other with coupling terms but without external fields, can be reduced to the case of the free-particle propagator when quasistatic solutions for this theory are used. © 1991 The American Physical Society.

Rho-omega mixing and the Nolen-Schiffer anomaly in relativistic nuclear models

We calculate within the framework of relativistic nuclear models the contribution of the ρ0 - ω mixing interaction to the binding energy differences of the mirror nuclei in the neighborhood of A = 16 and A = 40. We use two relativistic models for the nuclear structure, one with scalar and vector Woods-Saxon potentials, and the Walecka model. The ρ0 - ω interaction is treated in first order perturbation theory. When using the Walecka model the ρ- and ω-nucleon coupling constants are the same for calculating bound state wave functions and the perturbation due to the mixing. We find that the relativistic results on the average are of the same order as the ones obtained with nonrelativistic calculations.

Modeling architecture and reference models for the ERF5 project

The adoption of ERPs systems by small and middle-sized companies may not be possible due to their cost. At the same time, when adapting ERP to the company's particular needs, the user keeps depending on the system's sellers due to the lack of access and knowledge of the respective code. Free and open-source software may promote advantages to the enterprises, however, for its adoption it is necessary the development of techniques and tools in order to facilitate its deployment and code maintenance. This article emphasizes the importance of defining modeling architectures and reference models for the development and maintenance of open-source ERPs, in special the ERP5 project.