969 resultados para alternative splicing


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Despite a large body of literature focusing on how the normal aging process affects quality of life, little is known about how aging influences the lives of those who use alternative and augmentative communication (AAC). This article explores issues relevant to aging and AAC, examining the responses of 78 augmented communicators aged 30 years and older who participated in a larger national survey of 270 adults with cerebral palsy. The survey sought information about health, modes of communication, and access to information. The results indicate that those involved in the AAC field must work with individuals who use augmentative communication to ensure that they maintain their health, well-being, and effective communication as they age.

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Background : Although a wealth of studies have tested the link between negative mood states and likelihood of a subsequent binge eating episode, the assumption that this relationship follows a typical linear dose–response pattern (i.e., that risk of a binge episode increases in proportion to level of negative mood) has not been challenged. The present study demonstrates the applicability of an alternative, non-linear conceptualization of this relationship, in which the strength of association between negative mood and probability of a binge episode increases above a threshold value for the mood variable relative to the slope below this threshold value (threshold dose response model).

Methods
: A sample of 93 women aged 18 to 40 completed an online survey at random intervals seven times per day for a period of one week. Participants self-reported their current mood state and whether they had recently engaged in an eating episode symptomatic of a binge.

Results
: As hypothesized, the threshold approach was a better predictor than the linear dose–response modeling of likelihood of a binge episode. The superiority of the threshold approach was found even at low levels of negative mood (3 out of 10, with higher scores reflecting more  negative mood). Additionally, severity of negative mood beyond this threshold value appears to be useful for predicting time to onset of a binge episode.

Conclusions
: Present findings suggest that simple dose–response formulations for the association between  negative mood and onset of binge episodes miss vital aspects of this relationship. Most  notably, the impact of mood on binge eating appears to depend on whether a threshold value  of negative mood has been breached, and elevation in mood beyond this point may be useful  for clinicians and researchers to identify time to onset.

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The dynamism and mobility of architects in their approach to architecturaldesign practice provides a context that emphasises that architecture, likeculture, is not static or rooted in place, but is intricately configured throughthe dual processes of locality and mobility – both physical and theoretical. Theproduction of architecture in Australia, as in other immigrant-rich societies,provides a case for reinforcing the theory that architectural mobility and travelare integral to the architecture of place.This issues paper sets out to re-examine the contribution of geo-culturalinfluences upon Australia’s architectural lineage and considers a diverse rangeof themes across an equally broad timeframe; British colonial transpositions; thedissemination of Modernism in Australia; the latent contribution of mid-twentiethcentury European émigré architects; and the secreted history of Australia’sAsian architecture. Common to all, however, is the notion of architecturaltranslation as a process of influences transmitted, transposed or adapted toother contexts. It uses Australia as the focus from which to consider how globalcriticism, ideas and theories have travelled and continue to travel transverselyacross time and place, from the late-eighteenth century well into the twenty-first.This paper investigates translations through narratives, processes, networks andtraces of architectural manifestations and begins to draw lines of influence.

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Regional Support Network presents:A Sampled OZ Hystery: Australian Alternative Film from the 60s to the PresentTuesday, October 21, 8pm ($5 or PWYC)Videofag (187 Augusta Avenue)(co-sponsored by Videofag and Liaison of Independent Filmmakers of Toronto (LIFT))Curated by Dirk De Bruyn (in person)PROGRAM:Fun Radio - Nigel BuesstLeading Ladies - Lynsey MartinContemplation of the Rose - Michael LeeZoomfilm - Dirk de BruynDiscs - Dirk de BruynDolls - Paul FletcherExcerpt - Chris KnowlesExacuate - Michael Buckley and Sue McCauleyMorena - Marie CravenShort Lives - Neil TaylorE.G. (Elephant Girl) - Virginia HilyardTraum A Dream - Dirk de BruynKeepinTime Abstract - Steven McIntyreTime Ball - Marcia JaneWAP - Dirk de Bruyn

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Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine application. A wide range of alternative enhancers have been examined but to date none have been found to provide the dramatic increase in chemiluminescence intensities obtained using formaldehyde. Herein, we demonstrate that ethanol offers a simple, safe and inexpensive alternative to the use of formaldehyde for manganese(IV) chemiluminescence detection, without compromising signal intensity or sensitivity. For example, chemiluminescence signals for opiate alkaloids using 50-100% ethanol were 0.8-1.6-fold those using 2M formaldehyde. This innocuous alternative enhancer is shown to be a particularly effective for the direct detection of thiols and disulfides by manganese(IV) chemiluminescence, which we have applied to a simple HPLC procedure to determine a series of biomarkers of oxidative stress.